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Protein

Probable alpha/beta-glucosidase agdC

Gene

agdC

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei422 – 4221NucleophilePROSITE-ProRule annotation
Active sitei425 – 4251By similarity
Active sitei573 – 5731Proton donorBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB-EC
  2. beta-glucosidase activity Source: UniProtKB-EC
  3. carbohydrate binding Source: InterPro
  4. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha/beta-glucosidase agdC (EC:3.2.1.20, EC:3.2.1.21)
Gene namesi
Name:agdC
ORF Names:AO090005001084
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 1

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414Sequence AnalysisAdd
BLAST
Chaini15 – 877863Probable alpha/beta-glucosidase agdCPRO_0000394917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi610 – 6101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi744 – 7441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00002956.

Structurei

3D structure databases

ProteinModelPortaliQ2UQV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiDAYFPDD.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UQV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSLLLLAP LAGAAVIGSR ADTQQCPGYK ASNVQENDRS LTADLTLAGK
60 70 80 90 100
PCNTYGTDLH NLKLLVEYQT DERLHVKIYD AEERVYQVPE KVTPRVDSGD
110 120 130 140 150
GSSKDSALKF EYEEEPFSFT VKRDDEVLFD SSAENLIFQS QYLKLRTWLP
160 170 180 190 200
ENPYLYGLGE HTDPLRLSTT NYTRTFWNRD AYGTSANSNL YGTHPVYYDH
210 220 230 240 250
RGESGTHGVF LLNSNGMDVF IDKTADGKQY LEYNALGGIF DFYFFTGSNP
260 270 280 290 300
KEASIEYSKI VGLPAMQSYW TFGLHQCRYG YRDVYQVAEV VYNYTKAGIP
310 320 330 340 350
LETMWTDIDY MDRRRVFSLD PDRFPLEKMR ELVGYLHDHD QHYIVMVDPA
360 370 380 390 400
VSVSDNGAFN RGLEQDVFLK TQNGSLYKGA VWPGVTAYPD WFHPDIQDYW
410 420 430 440 450
NSEFSTFFNA ETGVDIDGLW IDMNEASNFC PDPCTDPERY SSENNLPPAP
460 470 480 490 500
PPVRSSSPRP LPGFPADFQP SSASRSQKRI VKAKVGLEGR DLLNPPYKIR
510 520 530 540 550
NEAGSLSNKT INTGIVHAGE GYAEYDTHNL YGTMMSSSSR EAMQYRRPEV
560 570 580 590 600
RPLVITRSTY AGAGRDVGHW LGDNFSKWEH YRISIAEGLA FASMFQVPMV
610 620 630 640 650
GADVCGFAGN TTEELCARWA SLGAFFTFYR NHNEIGNIGQ EFYVWPTVAE
660 670 680 690 700
SARKAIDIRY RLLDYIYTSF YKQSQTGEPF LQPVFYLYPE DENTFSIDLQ
710 720 730 740 750
FFYGDAILVS PVPDKGLTSV DAYFPDDIFY DWYTGTPVRG HGANITLSNI
760 770 780 790 800
DITHIPLHIR GGSIIPIRSS SAMTTTELRE KSFQLIIAPG LDGTASGSLY
810 820 830 840 850
LDDGDSLEQK ATLEVEFEYR KGVLHIDGKF ELHASLVESV TLLGQGKGGS
860 870
RARREDGTKK TIQTNLELSK PTEIKLE
Length:877
Mass (Da):98,791
Last modified:January 24, 2006 - v1
Checksum:i7AECADB4113F457F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE56058.1.
RefSeqiXP_001818060.1. XM_001818008.2.

Genome annotation databases

EnsemblFungiiCADAORAT00003003; CADAORAP00002956; CADAORAG00003003.
GeneIDi5990005.
KEGGiaor:AOR_1_1888174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE56058.1.
RefSeqiXP_001818060.1. XM_001818008.2.

3D structure databases

ProteinModelPortaliQ2UQV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5062.CADAORAP00002956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00003003; CADAORAP00002956; CADAORAG00003003.
GeneIDi5990005.
KEGGiaor:AOR_1_1888174.

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiDAYFPDD.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiAGDC_ASPOR
AccessioniPrimary (citable) accession number: Q2UQV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 24, 2006
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.