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Q2UPW4

- DAPB_ASPOR

UniProt

Q2UPW4 - DAPB_ASPOR

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, AO090005001482
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei740 – 7401Charge relay system By similarity
Active sitei817 – 8171Charge relay system By similarity
Active sitei850 – 8501Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:AO090005001482
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 1

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei79 – 9921Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini100 – 902803Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902Probable dipeptidyl-aminopeptidase B
PRO_0000412138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi626 – 6261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi794 – 7941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi799 – 7991N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00003299.

Structurei

3D structure databases

ProteinModelPortaliQ2UPW4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2UPW4-1 [UniParc]FASTAAdd to Basket

« Hide

MTRRRSTSGT SSRSSTDSGL SVDTAYLEDN KHNNFANGTS GLTDETKYRD    50
VEDAEADVDE PFLPTSSKKL GSGSRTRQIF WALVILCLGG WVLALVLFLT 100
HGRASSQTAS ETLQQQESDS GSTSAGRPVT LQQVLTGSWN PRAHAISWIA 150
GPDGEDGLLV QRAEVDKEGY MRVDDIRSQE GDDVDSQSGR ILIDKAAVRV 200
NGETLMPTFT WPSPDLNKVL LMSNHEKNWR YSFTGRYWIF DVATQTAQPL 250
DPSVPDGRVQ LALWSPSSDA VVFVRDNNMY LRKLSSESVV SITKDGGEDL 300
FYGIPDWVYE EEVITDKSVT WWSNDGKYVA FLRTNESAVP EFPVQYFVSR 350
PSGKRPPPGL ENYPEVRQIK YPKAGSPNPV VNLLFYDVEK DEVFPVDVPD 400
DFPDDDRIII EVLWASEGKV IVRATNRESD RVKVFLIDTK SRTGKLVRFE 450
DIANLDGGWV EPSHYTKFIP ADPSNGRPDD GYIDTVIHDG YDHLAYFTPL 500
DNPDPIMLTT GEWEVVEAPS AVDLRRGIVY FVATKESPTQ RHVYRVHLDG 550
SNLQALTDTS KPGFYDVSFS DGAGYALLSY NGPSVPWQAI INTGGDEITF 600
EKTIEKNPRL ASMVETYALP TEIYQNVTID GFTLQLVERR PPHFNPAKKY 650
PVVFQLYNGP TSQRVDRKFT IDFQSYIASN LGYIVVTLDA RGTGYSGRKV 700
RCAVRGNLGH YEAHDQITTA KMWAKKPYVD ETRMAIWGWS YGGFMTLKVL 750
EQDAGETFQY GMAVAPVTDW RFYDSVYTER YMHTPEHNPS GYENSTITNV 800
SALSKATRFL LIHGASDDNV HIQNTLTFVD KLDLLNVQNY DMHFYPDSDH 850
NIYFHNAHFM IYERLSNWLI NAFNGEWHQI ANPVPEDSIW DSVKRSVPAF 900
AH 902
Length:902
Mass (Da):101,664
Last modified:January 24, 2006 - v1
Checksum:i682AE97AABC5F565
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007151 Genomic DNA. Translation: BAE56401.1.

Genome annotation databases

EnsemblFungiiCADAORAT00003356; CADAORAP00003299; CADAORAG00003356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007151 Genomic DNA. Translation: BAE56401.1 .

3D structure databases

ProteinModelPortali Q2UPW4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00003299.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00003356 ; CADAORAP00003299 ; CADAORAG00003356 .

Phylogenomic databases

HOGENOMi HOG000189891.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiDAPB_ASPOR
AccessioniPrimary (citable) accession number: Q2UPW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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