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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei740Charge relay systemBy similarity1
Active sitei817Charge relay systemBy similarity1
Active sitei850Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERiaspor-q2upw4 DPP4N_Peptidase_S9
MEROPSiS09.006

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:AO090005001482
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicSequence analysisAdd BLAST78
Transmembranei79 – 99Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini100 – 902VacuolarSequence analysisAdd BLAST803

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121381 – 902Probable dipeptidyl-aminopeptidase BAdd BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi794N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi799N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00003299

Structurei

3D structure databases

ProteinModelPortaliQ2UPW4
SMRiQ2UPW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891
OrthoDBiEOG092C0PZJ

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q2UPW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRRSTSGT SSRSSTDSGL SVDTAYLEDN KHNNFANGTS GLTDETKYRD
60 70 80 90 100
VEDAEADVDE PFLPTSSKKL GSGSRTRQIF WALVILCLGG WVLALVLFLT
110 120 130 140 150
HGRASSQTAS ETLQQQESDS GSTSAGRPVT LQQVLTGSWN PRAHAISWIA
160 170 180 190 200
GPDGEDGLLV QRAEVDKEGY MRVDDIRSQE GDDVDSQSGR ILIDKAAVRV
210 220 230 240 250
NGETLMPTFT WPSPDLNKVL LMSNHEKNWR YSFTGRYWIF DVATQTAQPL
260 270 280 290 300
DPSVPDGRVQ LALWSPSSDA VVFVRDNNMY LRKLSSESVV SITKDGGEDL
310 320 330 340 350
FYGIPDWVYE EEVITDKSVT WWSNDGKYVA FLRTNESAVP EFPVQYFVSR
360 370 380 390 400
PSGKRPPPGL ENYPEVRQIK YPKAGSPNPV VNLLFYDVEK DEVFPVDVPD
410 420 430 440 450
DFPDDDRIII EVLWASEGKV IVRATNRESD RVKVFLIDTK SRTGKLVRFE
460 470 480 490 500
DIANLDGGWV EPSHYTKFIP ADPSNGRPDD GYIDTVIHDG YDHLAYFTPL
510 520 530 540 550
DNPDPIMLTT GEWEVVEAPS AVDLRRGIVY FVATKESPTQ RHVYRVHLDG
560 570 580 590 600
SNLQALTDTS KPGFYDVSFS DGAGYALLSY NGPSVPWQAI INTGGDEITF
610 620 630 640 650
EKTIEKNPRL ASMVETYALP TEIYQNVTID GFTLQLVERR PPHFNPAKKY
660 670 680 690 700
PVVFQLYNGP TSQRVDRKFT IDFQSYIASN LGYIVVTLDA RGTGYSGRKV
710 720 730 740 750
RCAVRGNLGH YEAHDQITTA KMWAKKPYVD ETRMAIWGWS YGGFMTLKVL
760 770 780 790 800
EQDAGETFQY GMAVAPVTDW RFYDSVYTER YMHTPEHNPS GYENSTITNV
810 820 830 840 850
SALSKATRFL LIHGASDDNV HIQNTLTFVD KLDLLNVQNY DMHFYPDSDH
860 870 880 890 900
NIYFHNAHFM IYERLSNWLI NAFNGEWHQI ANPVPEDSIW DSVKRSVPAF

AH
Length:902
Mass (Da):101,664
Last modified:January 24, 2006 - v1
Checksum:i682AE97AABC5F565
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA Translation: BAE56401.1
RefSeqiXP_001818403.2, XM_001818351.2

Genome annotation databases

EnsemblFungiiBAE56401; BAE56401; AO090005001482
GeneIDi5990348

Similar proteinsi

Entry informationi

Entry nameiDAPB_ASPOR
AccessioniPrimary (citable) accession number: Q2UPW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health