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Q2UPW4 (DAPB_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:AO090005001482
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length902 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 902902Probable dipeptidyl-aminopeptidase B
PRO_0000412138

Regions

Topological domain1 – 7878Cytoplasmic Potential
Transmembrane79 – 9921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain100 – 902803Vacuolar Potential

Sites

Active site7401Charge relay system By similarity
Active site8171Charge relay system By similarity
Active site8501Charge relay system By similarity

Amino acid modifications

Glycosylation3351N-linked (GlcNAc...) Potential
Glycosylation6261N-linked (GlcNAc...) Potential
Glycosylation7941N-linked (GlcNAc...) Potential
Glycosylation7991N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2UPW4 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 682AE97AABC5F565

FASTA902101,664
        10         20         30         40         50         60 
MTRRRSTSGT SSRSSTDSGL SVDTAYLEDN KHNNFANGTS GLTDETKYRD VEDAEADVDE 

        70         80         90        100        110        120 
PFLPTSSKKL GSGSRTRQIF WALVILCLGG WVLALVLFLT HGRASSQTAS ETLQQQESDS 

       130        140        150        160        170        180 
GSTSAGRPVT LQQVLTGSWN PRAHAISWIA GPDGEDGLLV QRAEVDKEGY MRVDDIRSQE 

       190        200        210        220        230        240 
GDDVDSQSGR ILIDKAAVRV NGETLMPTFT WPSPDLNKVL LMSNHEKNWR YSFTGRYWIF 

       250        260        270        280        290        300 
DVATQTAQPL DPSVPDGRVQ LALWSPSSDA VVFVRDNNMY LRKLSSESVV SITKDGGEDL 

       310        320        330        340        350        360 
FYGIPDWVYE EEVITDKSVT WWSNDGKYVA FLRTNESAVP EFPVQYFVSR PSGKRPPPGL 

       370        380        390        400        410        420 
ENYPEVRQIK YPKAGSPNPV VNLLFYDVEK DEVFPVDVPD DFPDDDRIII EVLWASEGKV 

       430        440        450        460        470        480 
IVRATNRESD RVKVFLIDTK SRTGKLVRFE DIANLDGGWV EPSHYTKFIP ADPSNGRPDD 

       490        500        510        520        530        540 
GYIDTVIHDG YDHLAYFTPL DNPDPIMLTT GEWEVVEAPS AVDLRRGIVY FVATKESPTQ 

       550        560        570        580        590        600 
RHVYRVHLDG SNLQALTDTS KPGFYDVSFS DGAGYALLSY NGPSVPWQAI INTGGDEITF 

       610        620        630        640        650        660 
EKTIEKNPRL ASMVETYALP TEIYQNVTID GFTLQLVERR PPHFNPAKKY PVVFQLYNGP 

       670        680        690        700        710        720 
TSQRVDRKFT IDFQSYIASN LGYIVVTLDA RGTGYSGRKV RCAVRGNLGH YEAHDQITTA 

       730        740        750        760        770        780 
KMWAKKPYVD ETRMAIWGWS YGGFMTLKVL EQDAGETFQY GMAVAPVTDW RFYDSVYTER 

       790        800        810        820        830        840 
YMHTPEHNPS GYENSTITNV SALSKATRFL LIHGASDDNV HIQNTLTFVD KLDLLNVQNY 

       850        860        870        880        890        900 
DMHFYPDSDH NIYFHNAHFM IYERLSNWLI NAFNGEWHQI ANPVPEDSIW DSVKRSVPAF 


AH 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007151 Genomic DNA. Translation: BAE56401.1.

3D structure databases

ProteinModelPortalQ2UPW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00003299.

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00003356; CADAORAP00003299; CADAORAG00003356.

Phylogenomic databases

HOGENOMHOG000189891.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_ASPOR
AccessionPrimary (citable) accession number: Q2UPW4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries