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Q2UPT7 (FKBP2_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FK506-binding protein 2

EC=5.2.1.8
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase
Gene names
Name:fpr2
ORF Names:AO090005001515
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP2 subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionIsomerase
Rotamase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 134115FK506-binding protein 2
PRO_0000233064

Regions

Domain39 – 12789PPIase FKBP-type
Motif131 – 1344Prevents secretion from ER Potential

Sequences

Sequence LengthMass (Da)Tools
Q2UPT7 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 033183381DFD9825

FASTA13414,524
        10         20         30         40         50         60 
MRFSIFSTLL VSLATLSTAA ELGIEKTHEV ECTRKTVKGD TVQMHYKGTL QSDGSEFDSS 

        70         80         90        100        110        120 
YKRNSPLKFK VGSGMVIKGW DEGLLDMCIG EKRTLTIPPE YGYGSRGVGP IPGGATLIFE 

       130 
TELVGIDGVS KDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007151 Genomic DNA. Translation: BAE56428.1.
RefSeqXP_001818430.1. XM_001818378.2.

3D structure databases

ProteinModelPortalQ2UPT7.
SMRQ2UPT7. Positions 35-127.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00003326.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00003383; CADAORAP00003326; CADAORAG00003383.
GeneID5990375.
KEGGaor:AOR_1_2634174.

Phylogenomic databases

eggNOGCOG0545.
HOGENOMHOG000154887.
KOK09569.
OMAKRVENCT.
OrthoDBEOG77WWQ3.

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFKBP2_ASPOR
AccessionPrimary (citable) accession number: Q2UPT7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families