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Protein

FK506-binding protein 2

Gene

fpr2

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:fpr2
ORF Names:AO090005001515
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000023306420 – 134FK506-binding protein 2Add BLAST115

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00003326

Structurei

3D structure databases

ProteinModelPortaliQ2UPT7
SMRiQ2UPT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 127PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 134Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000154887
KOiK09569
OMAiGILGMCE
OrthoDBiEOG092C52SD

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UPT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSIFSTLL VSLATLSTAA ELGIEKTHEV ECTRKTVKGD TVQMHYKGTL
60 70 80 90 100
QSDGSEFDSS YKRNSPLKFK VGSGMVIKGW DEGLLDMCIG EKRTLTIPPE
110 120 130
YGYGSRGVGP IPGGATLIFE TELVGIDGVS KDEL
Length:134
Mass (Da):14,524
Last modified:January 24, 2006 - v1
Checksum:i033183381DFD9825
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA Translation: BAE56428.1
RefSeqiXP_001818430.1, XM_001818378.2

Genome annotation databases

EnsemblFungiiBAE56428; BAE56428; AO090005001515
GeneIDi5990375
KEGGiaor:AO090005001515

Similar proteinsi

Entry informationi

Entry nameiFKBP2_ASPOR
AccessioniPrimary (citable) accession number: Q2UPT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health