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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193PROSITE-ProRule annotation1
Active sitei390PROSITE-ProRule annotation1
Active sitei452PROSITE-ProRule annotation1

GO - Molecular functioni

  • serine-type carboxypeptidase activity Source: ASPGD

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • hyphal growth Source: ASPGD
  • positive regulation of conidium formation Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERiaspor-q2upi1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:AO090005001632
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 523LumenalSequence analysisAdd BLAST482
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 625CytoplasmicSequence analysisAdd BLAST81

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000041190542 – 625Pheromone-processing carboxypeptidase kex1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi501N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2UPI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiDMAREHY.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UPI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSISRGFA KSETGDTFSF SFKSSWLLSL LVLWGPPLTT AKSAADYYVR
60 70 80 90 100
SLPGAPDGPL LKMHAGHIEV DPQNNGNLFF WHYQNRHIAN RQRTVIWLNG
110 120 130 140 150
GPGCSSMDGA LMEVGPYRLK DNLTLEYNEG SWDEFANLLF VDQPVGTGFS
160 170 180 190 200
YVNTDSYLHE LDEMSAHFII FLDKFFELFP EYEGDDIYLA GESYAGQHIP
210 220 230 240 250
YIAKAILDRN KNAVSPWNLR GLLIGNGWIS PADQYPSYLT FAYEEGLIKE
260 270 280 290 300
DSRTAKSLEV LQSVCQSKLE TGGKDRIHIG DCETVLQELL SKTLDSDNKC
310 320 330 340 350
YNMYDIRLRD TVPSCGMNWP QDLKDVKPYL RRADVVKALN INPEKKSGWE
360 370 380 390 400
ECSGAVSSSF LPQKSVPAVQ LLPSLLESGI SVLLFSGDKD LICNHVGTEQ
410 420 430 440 450
LINNMKWGGG VGFETSPGVW APRHDWTFEG EPAGIYQHAR NLTYVLLYNS
460 470 480 490 500
SHMAPYDLPR QTRDMLDRFM KVDIASIGGS PADSRIDGEK LPQTSVGGHP
510 520 530 540 550
NSTAAEEQEK ERMKQAEWKA YAKSGEAVLV VVIIGVSVWG FFIWRSRQRH
560 570 580 590 600
RRYQGLYHED VSGASVLERF HNKRSGQDVE AGDFDESELD DLHSPDMARE
610 620
HYTVGEDSDE DDVNRQHQRT TINPS
Length:625
Mass (Da):70,272
Last modified:January 24, 2006 - v1
Checksum:i721A55B7A7097E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE56534.1.
RefSeqiXP_001818536.1. XM_001818484.2.

Genome annotation databases

EnsemblFungiiBAE56534; BAE56534; AO090005001632.
GeneIDi5990481.
KEGGiaor:AOR_1_2862174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE56534.1.
RefSeqiXP_001818536.1. XM_001818484.2.

3D structure databases

ProteinModelPortaliQ2UPI1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspor-q2upi1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAE56534; BAE56534; AO090005001632.
GeneIDi5990481.
KEGGiaor:AOR_1_2862174.

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiDMAREHY.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_ASPOR
AccessioniPrimary (citable) accession number: Q2UPI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.