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Q2UPI1

- KEX1_ASPOR

UniProt

Q2UPI1 - KEX1_ASPOR

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei193 – 1931PROSITE-ProRule annotation
    Active sitei390 – 3901PROSITE-ProRule annotation
    Active sitei452 – 4521PROSITE-ProRule annotation

    GO - Molecular functioni

    1. carboxypeptidase activity Source: ASPGD
    2. serine-type carboxypeptidase activity Source: ASPGD

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. hyphal growth Source: ASPGD
    3. positive regulation of conidium formation Source: ASPGD
    4. proteolysis Source: ASPGD

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:kex1
    ORF Names:AO090005001632
    OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
    Taxonomic identifieri510516 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006564: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Chaini42 – 625584Pheromone-processing carboxypeptidase kex1PRO_0000411905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5062.CADAORAP00003432.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2UPI1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini42 – 523482LumenalSequence AnalysisAdd
    BLAST
    Topological domaini545 – 62581CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiDMAREHY.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2UPI1-1 [UniParc]FASTAAdd to Basket

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    MFSSISRGFA KSETGDTFSF SFKSSWLLSL LVLWGPPLTT AKSAADYYVR    50
    SLPGAPDGPL LKMHAGHIEV DPQNNGNLFF WHYQNRHIAN RQRTVIWLNG 100
    GPGCSSMDGA LMEVGPYRLK DNLTLEYNEG SWDEFANLLF VDQPVGTGFS 150
    YVNTDSYLHE LDEMSAHFII FLDKFFELFP EYEGDDIYLA GESYAGQHIP 200
    YIAKAILDRN KNAVSPWNLR GLLIGNGWIS PADQYPSYLT FAYEEGLIKE 250
    DSRTAKSLEV LQSVCQSKLE TGGKDRIHIG DCETVLQELL SKTLDSDNKC 300
    YNMYDIRLRD TVPSCGMNWP QDLKDVKPYL RRADVVKALN INPEKKSGWE 350
    ECSGAVSSSF LPQKSVPAVQ LLPSLLESGI SVLLFSGDKD LICNHVGTEQ 400
    LINNMKWGGG VGFETSPGVW APRHDWTFEG EPAGIYQHAR NLTYVLLYNS 450
    SHMAPYDLPR QTRDMLDRFM KVDIASIGGS PADSRIDGEK LPQTSVGGHP 500
    NSTAAEEQEK ERMKQAEWKA YAKSGEAVLV VVIIGVSVWG FFIWRSRQRH 550
    RRYQGLYHED VSGASVLERF HNKRSGQDVE AGDFDESELD DLHSPDMARE 600
    HYTVGEDSDE DDVNRQHQRT TINPS 625
    Length:625
    Mass (Da):70,272
    Last modified:January 24, 2006 - v1
    Checksum:i721A55B7A7097E83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007151 Genomic DNA. Translation: BAE56534.1.
    RefSeqiXP_001818536.1. XM_001818484.2.

    Genome annotation databases

    EnsemblFungiiCADAORAT00003489; CADAORAP00003432; CADAORAG00003489.
    GeneIDi5990481.
    KEGGiaor:AOR_1_2862174.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007151 Genomic DNA. Translation: BAE56534.1 .
    RefSeqi XP_001818536.1. XM_001818484.2.

    3D structure databases

    ProteinModelPortali Q2UPI1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5062.CADAORAP00003432.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAORAT00003489 ; CADAORAP00003432 ; CADAORAG00003489 .
    GeneIDi 5990481.
    KEGGi aor:AOR_1_2862174.

    Phylogenomic databases

    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi DMAREHY.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of Aspergillus oryzae."
      Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
      , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
      Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42149 / RIB 40.

    Entry informationi

    Entry nameiKEX1_ASPOR
    AccessioniPrimary (citable) accession number: Q2UPI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3