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Q2UPI1

- KEX1_ASPOR

UniProt

Q2UPI1 - KEX1_ASPOR

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Protein

Pheromone-processing carboxypeptidase kex1

Gene
kex1, AO090005001632
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei193 – 1931 By similarity
Active sitei390 – 3901 By similarity
Active sitei452 – 4521 By similarity

GO - Molecular functioni

  1. carboxypeptidase activity Source: ASPGD
  2. serine-type carboxypeptidase activity Source: ASPGD

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. hyphal growth Source: ASPGD
  3. positive regulation of conidium formation Source: ASPGD
  4. proteolysis Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:AO090005001632
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 523482Lumenal Reviewed predictionAdd
BLAST
Transmembranei524 – 54421Helical; Reviewed predictionAdd
BLAST
Topological domaini545 – 62581Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141 Reviewed predictionAdd
BLAST
Chaini42 – 625584Pheromone-processing carboxypeptidase kex1PRO_0000411905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi449 – 4491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi501 – 5011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00003432.

Structurei

3D structure databases

ProteinModelPortaliQ2UPI1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiDMAREHY.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UPI1-1 [UniParc]FASTAAdd to Basket

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MFSSISRGFA KSETGDTFSF SFKSSWLLSL LVLWGPPLTT AKSAADYYVR    50
SLPGAPDGPL LKMHAGHIEV DPQNNGNLFF WHYQNRHIAN RQRTVIWLNG 100
GPGCSSMDGA LMEVGPYRLK DNLTLEYNEG SWDEFANLLF VDQPVGTGFS 150
YVNTDSYLHE LDEMSAHFII FLDKFFELFP EYEGDDIYLA GESYAGQHIP 200
YIAKAILDRN KNAVSPWNLR GLLIGNGWIS PADQYPSYLT FAYEEGLIKE 250
DSRTAKSLEV LQSVCQSKLE TGGKDRIHIG DCETVLQELL SKTLDSDNKC 300
YNMYDIRLRD TVPSCGMNWP QDLKDVKPYL RRADVVKALN INPEKKSGWE 350
ECSGAVSSSF LPQKSVPAVQ LLPSLLESGI SVLLFSGDKD LICNHVGTEQ 400
LINNMKWGGG VGFETSPGVW APRHDWTFEG EPAGIYQHAR NLTYVLLYNS 450
SHMAPYDLPR QTRDMLDRFM KVDIASIGGS PADSRIDGEK LPQTSVGGHP 500
NSTAAEEQEK ERMKQAEWKA YAKSGEAVLV VVIIGVSVWG FFIWRSRQRH 550
RRYQGLYHED VSGASVLERF HNKRSGQDVE AGDFDESELD DLHSPDMARE 600
HYTVGEDSDE DDVNRQHQRT TINPS 625
Length:625
Mass (Da):70,272
Last modified:January 24, 2006 - v1
Checksum:i721A55B7A7097E83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007151 Genomic DNA. Translation: BAE56534.1.
RefSeqiXP_001818536.1. XM_001818484.2.

Genome annotation databases

EnsemblFungiiCADAORAT00003489; CADAORAP00003432; CADAORAG00003489.
GeneIDi5990481.
KEGGiaor:AOR_1_2862174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007151 Genomic DNA. Translation: BAE56534.1 .
RefSeqi XP_001818536.1. XM_001818484.2.

3D structure databases

ProteinModelPortali Q2UPI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00003432.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00003489 ; CADAORAP00003432 ; CADAORAG00003489 .
GeneIDi 5990481.
KEGGi aor:AOR_1_2862174.

Phylogenomic databases

HOGENOMi HOG000208879.
KOi K01288.
OMAi DMAREHY.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiKEX1_ASPOR
AccessioniPrimary (citable) accession number: Q2UPI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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