Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2UPI1

- KEX1_ASPOR

UniProt

Q2UPI1 - KEX1_ASPOR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei193 – 1931PROSITE-ProRule annotation
Active sitei390 – 3901PROSITE-ProRule annotation
Active sitei452 – 4521PROSITE-ProRule annotation

GO - Molecular functioni

  1. carboxypeptidase activity Source: ASPGD
  2. serine-type carboxypeptidase activity Source: ASPGD

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. hyphal growth Source: ASPGD
  3. positive regulation of conidium formation Source: ASPGD
  4. proteolysis Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:AO090005001632
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 523482LumenalSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 62581CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence AnalysisAdd
BLAST
Chaini42 – 625584Pheromone-processing carboxypeptidase kex1PRO_0000411905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00003432.

Structurei

3D structure databases

ProteinModelPortaliQ2UPI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiDMAREHY.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UPI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSSISRGFA KSETGDTFSF SFKSSWLLSL LVLWGPPLTT AKSAADYYVR
60 70 80 90 100
SLPGAPDGPL LKMHAGHIEV DPQNNGNLFF WHYQNRHIAN RQRTVIWLNG
110 120 130 140 150
GPGCSSMDGA LMEVGPYRLK DNLTLEYNEG SWDEFANLLF VDQPVGTGFS
160 170 180 190 200
YVNTDSYLHE LDEMSAHFII FLDKFFELFP EYEGDDIYLA GESYAGQHIP
210 220 230 240 250
YIAKAILDRN KNAVSPWNLR GLLIGNGWIS PADQYPSYLT FAYEEGLIKE
260 270 280 290 300
DSRTAKSLEV LQSVCQSKLE TGGKDRIHIG DCETVLQELL SKTLDSDNKC
310 320 330 340 350
YNMYDIRLRD TVPSCGMNWP QDLKDVKPYL RRADVVKALN INPEKKSGWE
360 370 380 390 400
ECSGAVSSSF LPQKSVPAVQ LLPSLLESGI SVLLFSGDKD LICNHVGTEQ
410 420 430 440 450
LINNMKWGGG VGFETSPGVW APRHDWTFEG EPAGIYQHAR NLTYVLLYNS
460 470 480 490 500
SHMAPYDLPR QTRDMLDRFM KVDIASIGGS PADSRIDGEK LPQTSVGGHP
510 520 530 540 550
NSTAAEEQEK ERMKQAEWKA YAKSGEAVLV VVIIGVSVWG FFIWRSRQRH
560 570 580 590 600
RRYQGLYHED VSGASVLERF HNKRSGQDVE AGDFDESELD DLHSPDMARE
610 620
HYTVGEDSDE DDVNRQHQRT TINPS
Length:625
Mass (Da):70,272
Last modified:January 24, 2006 - v1
Checksum:i721A55B7A7097E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE56534.1.
RefSeqiXP_001818536.1. XM_001818484.2.

Genome annotation databases

EnsemblFungiiCADAORAT00003489; CADAORAP00003432; CADAORAG00003489.
GeneIDi5990481.
KEGGiaor:AOR_1_2862174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007151 Genomic DNA. Translation: BAE56534.1 .
RefSeqi XP_001818536.1. XM_001818484.2.

3D structure databases

ProteinModelPortali Q2UPI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00003432.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00003489 ; CADAORAP00003432 ; CADAORAG00003489 .
GeneIDi 5990481.
KEGGi aor:AOR_1_2862174.

Phylogenomic databases

HOGENOMi HOG000208879.
KOi K01288.
OMAi DMAREHY.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiKEX1_ASPOR
AccessioniPrimary (citable) accession number: Q2UPI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3