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Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi563Zinc; catalyticPROSITE-ProRule annotation1
Active sitei564PROSITE-ProRule annotation1
Metal bindingi567Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi570Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:AO090001000525
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionSequence analysisAdd BLAST23
ChainiPRO_000033857324 – 800Mitochondrial intermediate peptidaseAdd BLAST777

Structurei

3D structure databases

ProteinModelPortaliQ2UN31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UN31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHMLMPLR RRPWTCRACL QRLQQPRRSL ETAASPSSQS DVYDYAPTNH
60 70 80 90 100
STQKKSNDET LRRVFDSQPF WREFSQRSAT QSKPTGLVQN QYLTNPDGFR
110 120 130 140 150
AFANVSLQRC QAIVAKVLAA STLEEYRDMA RDLDRLSDLL CRVIDLSDFI
160 170 180 190 200
RVIHPDPRVQ EAATQAYALM FEYMNVLNTT TGLNDQLKKA ASNPDVTSYW
210 220 230 240 250
SEEEKIVAQI LIKDFSNSAI HMPPNERQRF VNLSNDISQL GSNFVNSAEP
260 270 280 290 300
AKSQVVVGAN SLRGLDPILV QQIRRWNRTA SVPTTGMIPR LALRSVHDEG
310 320 330 340 350
VRREVYLATR TSSSRQLHRL EELLSKRAEL AQLSGHASFG HMTLSDKMAK
360 370 380 390 400
SPEAVSNFLT ALVGSNREYV QEELSKLQAM KGGSPLQPWD HAYYVHQRVL
410 420 430 440 450
QYSQSRRSRE LSAVPEFFSL GTVMQGLSRL FDRLYGVRLV PQETAAGETW
460 470 480 490 500
NPDVRRLDVV DEAERHIAVI YCDLFSRPNK HPNPAHFTLR CAREISSEEV
510 520 530 540 550
AECATMDHSA HPNDGMATAV DPQSKTLRQL PTIALVCDFA EPPATGAGRP
560 570 580 590 600
SLLSEHSVRT LFHEMGHALH SILGQTRLQS ISGTRCATDF AELPSVLMER
610 620 630 640 650
FATEPAVLSM YARHWQTDQP LSESMMLSME KDRLAHGSIY GAVENEAQIL
660 670 680 690 700
MALVDQAYHS IPADKAGQID STAIYHQVSS AHSTLPDPTD SRPPTSWQGF
710 720 730 740 750
FGHLYGYGAT YYSYIFDRAI ANKIWEDVFQ AGKAAVDREA GERYKNEVLR
760 770 780 790 800
WGGGRNGWDC VAGVLGSANA ANANGRLAEG GDEAMREVGR WGLGRDGVSG
Length:800
Mass (Da):89,243
Last modified:January 24, 2006 - v1
Checksum:i474F93077541B66F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007154 Genomic DNA Translation: BAE57034.1
RefSeqiXP_001819036.1, XM_001818984.1

Genome annotation databases

EnsemblFungiiBAE57034; BAE57034; AO090001000525
GeneIDi5991007
KEGGiaor:AO090001000525

Similar proteinsi

Entry informationi

Entry nameiPMIP_ASPOR
AccessioniPrimary (citable) accession number: Q2UN31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health