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Q2UN31

- PMIP_ASPOR

UniProt

Q2UN31 - PMIP_ASPOR

Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi563 – 5631Zinc; catalyticPROSITE-ProRule annotation
    Active sitei564 – 5641PROSITE-ProRule annotation
    Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi570 – 5701Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct1
    ORF Names:AO090001000525
    OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
    Taxonomic identifieri510516 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006564: Chromosome 2

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2323MitochondrionSequence AnalysisAdd
    BLAST
    Chaini24 – 800777Mitochondrial intermediate peptidasePRO_0000338573Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5062.CADAORAP00000468.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2UN31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OMAiHATHGDG.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2UN31-1 [UniParc]FASTAAdd to Basket

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    MAGHMLMPLR RRPWTCRACL QRLQQPRRSL ETAASPSSQS DVYDYAPTNH    50
    STQKKSNDET LRRVFDSQPF WREFSQRSAT QSKPTGLVQN QYLTNPDGFR 100
    AFANVSLQRC QAIVAKVLAA STLEEYRDMA RDLDRLSDLL CRVIDLSDFI 150
    RVIHPDPRVQ EAATQAYALM FEYMNVLNTT TGLNDQLKKA ASNPDVTSYW 200
    SEEEKIVAQI LIKDFSNSAI HMPPNERQRF VNLSNDISQL GSNFVNSAEP 250
    AKSQVVVGAN SLRGLDPILV QQIRRWNRTA SVPTTGMIPR LALRSVHDEG 300
    VRREVYLATR TSSSRQLHRL EELLSKRAEL AQLSGHASFG HMTLSDKMAK 350
    SPEAVSNFLT ALVGSNREYV QEELSKLQAM KGGSPLQPWD HAYYVHQRVL 400
    QYSQSRRSRE LSAVPEFFSL GTVMQGLSRL FDRLYGVRLV PQETAAGETW 450
    NPDVRRLDVV DEAERHIAVI YCDLFSRPNK HPNPAHFTLR CAREISSEEV 500
    AECATMDHSA HPNDGMATAV DPQSKTLRQL PTIALVCDFA EPPATGAGRP 550
    SLLSEHSVRT LFHEMGHALH SILGQTRLQS ISGTRCATDF AELPSVLMER 600
    FATEPAVLSM YARHWQTDQP LSESMMLSME KDRLAHGSIY GAVENEAQIL 650
    MALVDQAYHS IPADKAGQID STAIYHQVSS AHSTLPDPTD SRPPTSWQGF 700
    FGHLYGYGAT YYSYIFDRAI ANKIWEDVFQ AGKAAVDREA GERYKNEVLR 750
    WGGGRNGWDC VAGVLGSANA ANANGRLAEG GDEAMREVGR WGLGRDGVSG 800
    Length:800
    Mass (Da):89,243
    Last modified:January 24, 2006 - v1
    Checksum:i474F93077541B66F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007154 Genomic DNA. Translation: BAE57034.1.
    RefSeqiXP_001819036.1. XM_001818984.1.

    Genome annotation databases

    EnsemblFungiiCADAORAT00000479; CADAORAP00000468; CADAORAG00000479.
    GeneIDi5991007.
    KEGGiaor:AOR_1_1462164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007154 Genomic DNA. Translation: BAE57034.1 .
    RefSeqi XP_001819036.1. XM_001818984.1.

    3D structure databases

    ProteinModelPortali Q2UN31.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5062.CADAORAP00000468.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAORAT00000479 ; CADAORAP00000468 ; CADAORAG00000479 .
    GeneIDi 5991007.
    KEGGi aor:AOR_1_1462164.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OMAi HATHGDG.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of Aspergillus oryzae."
      Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
      , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
      Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42149 / RIB 40.

    Entry informationi

    Entry nameiPMIP_ASPOR
    AccessioniPrimary (citable) accession number: Q2UN31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3