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Q2UN31

- PMIP_ASPOR

UniProt

Q2UN31 - PMIP_ASPOR

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Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi563 – 5631Zinc; catalyticPROSITE-ProRule annotation
Active sitei564 – 5641PROSITE-ProRule annotation
Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi570 – 5701Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:AO090001000525
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 2

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323MitochondrionSequence AnalysisAdd
BLAST
Chaini24 – 800777Mitochondrial intermediate peptidasePRO_0000338573Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00000468.

Structurei

3D structure databases

ProteinModelPortaliQ2UN31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
KOiK01410.
OMAiHATHGDG.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UN31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGHMLMPLR RRPWTCRACL QRLQQPRRSL ETAASPSSQS DVYDYAPTNH
60 70 80 90 100
STQKKSNDET LRRVFDSQPF WREFSQRSAT QSKPTGLVQN QYLTNPDGFR
110 120 130 140 150
AFANVSLQRC QAIVAKVLAA STLEEYRDMA RDLDRLSDLL CRVIDLSDFI
160 170 180 190 200
RVIHPDPRVQ EAATQAYALM FEYMNVLNTT TGLNDQLKKA ASNPDVTSYW
210 220 230 240 250
SEEEKIVAQI LIKDFSNSAI HMPPNERQRF VNLSNDISQL GSNFVNSAEP
260 270 280 290 300
AKSQVVVGAN SLRGLDPILV QQIRRWNRTA SVPTTGMIPR LALRSVHDEG
310 320 330 340 350
VRREVYLATR TSSSRQLHRL EELLSKRAEL AQLSGHASFG HMTLSDKMAK
360 370 380 390 400
SPEAVSNFLT ALVGSNREYV QEELSKLQAM KGGSPLQPWD HAYYVHQRVL
410 420 430 440 450
QYSQSRRSRE LSAVPEFFSL GTVMQGLSRL FDRLYGVRLV PQETAAGETW
460 470 480 490 500
NPDVRRLDVV DEAERHIAVI YCDLFSRPNK HPNPAHFTLR CAREISSEEV
510 520 530 540 550
AECATMDHSA HPNDGMATAV DPQSKTLRQL PTIALVCDFA EPPATGAGRP
560 570 580 590 600
SLLSEHSVRT LFHEMGHALH SILGQTRLQS ISGTRCATDF AELPSVLMER
610 620 630 640 650
FATEPAVLSM YARHWQTDQP LSESMMLSME KDRLAHGSIY GAVENEAQIL
660 670 680 690 700
MALVDQAYHS IPADKAGQID STAIYHQVSS AHSTLPDPTD SRPPTSWQGF
710 720 730 740 750
FGHLYGYGAT YYSYIFDRAI ANKIWEDVFQ AGKAAVDREA GERYKNEVLR
760 770 780 790 800
WGGGRNGWDC VAGVLGSANA ANANGRLAEG GDEAMREVGR WGLGRDGVSG
Length:800
Mass (Da):89,243
Last modified:January 24, 2006 - v1
Checksum:i474F93077541B66F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007154 Genomic DNA. Translation: BAE57034.1.
RefSeqiXP_001819036.1. XM_001818984.1.

Genome annotation databases

EnsemblFungiiCADAORAT00000479; CADAORAP00000468; CADAORAG00000479.
GeneIDi5991007.
KEGGiaor:AOR_1_1462164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007154 Genomic DNA. Translation: BAE57034.1 .
RefSeqi XP_001819036.1. XM_001818984.1.

3D structure databases

ProteinModelPortali Q2UN31.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00000468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00000479 ; CADAORAP00000468 ; CADAORAG00000479 .
GeneIDi 5991007.
KEGGi aor:AOR_1_1462164.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
KOi K01410.
OMAi HATHGDG.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiPMIP_ASPOR
AccessioniPrimary (citable) accession number: Q2UN31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3