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Q2UN00 (MANBA_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-mannosidase A

EC=3.2.1.25
Alternative name(s):
Mannanase A
Short name=Mannase A
Gene names
Name:mndA
ORF Names:AO090001000556
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length914 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathway

Glycan metabolism; N-glycan degradation.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 914894Beta-mannosidase A
PRO_0000394647

Sites

Active site4621Proton donor By similarity

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation5911N-linked (GlcNAc...) Potential
Glycosylation6141N-linked (GlcNAc...) Potential
Glycosylation6411N-linked (GlcNAc...) Potential
Glycosylation7211N-linked (GlcNAc...) Potential
Glycosylation7441N-linked (GlcNAc...) Potential
Glycosylation7731N-linked (GlcNAc...) Potential
Glycosylation7841N-linked (GlcNAc...) Potential
Glycosylation9091N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2UN00 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: F56D1E1EFAC63821

FASTA914102,870
        10         20         30         40         50         60 
MRFTATAAAL VASSIPATLG QHVRDLSNEK WTLSSDALNH TVPGNLPSHA HLDLLKAGVI 

        70         80         90        100        110        120 
DDPYHGLNDF NLRWIPESNW TYTTDKIKDL MPIEFCGKYV ASTNNQYRQY SFDVSQILEG 

       130        140        150        160        170        180 
CNEDPILKID FGSAPNIVNA IAEDRNSPVW PDGIQQTYEY PNRWFMRKEQ SDFGWDWGPA 

       190        200        210        220        230        240 
FAPAGPWKPA YIVQLPKAQN IHVLNTDLDI YRKGQINHLP PDQSQPWVVN ASIDFVGSLP 

       250        260        270        280        290        300 
PNPSMSIEFK DTKSGEILTS KRIGNVTVSG NSVTGVTVLG GVTPKLWWPL GLGDQNLYNI 

       310        320        330        340        350        360 
TVTVTGHQNQ TLAHVTKRTG FRTIFLNQRN ITDAQLAQGI APGANWHFEV NGHEFYAKGS 

       370        380        390        400        410        420 
NIIPPDAFWP RVTEARMARL FDAVVAGNQN MLRVWSSGIY LHDFIYDLAD ERGILLWSEF 

       430        440        450        460        470        480 
EFSDALYPVD DAFLDNIAAE VVYNVRRVNH HPSLALWAGG NEIESLMLPT VERKAPEEYA 

       490        500        510        520        530        540 
KYVGEYEKLY ISLILPLVYQ NTRSITYSPS STTEGYLDVD LSAPVPMVER YHNTTPGSYY 

       550        560        570        580        590        600 
GDTDFYNYDS SVSFNSHVYP VGRFANEFGY HSMPSLQTWQ QAVDPEDLHF NSTTVMLRNH 

       610        620        630        640        650        660 
HYPAGGTFTD NFHNTSLGMG EMTIAVQRYY PIPNKLDSVA NFSAWCHATQ LFQADMYKSE 

       670        680        690        700        710        720 
IQFYRRGSGM PERQLGSLYW QLEDIWQAPS WAGIEYGGRW KVLHYVSRDI YQPIIVSPFW 

       730        740        750        760        770        780 
NYTTGDLDLY VTSDLWESAK GKVNLTWLDL SGTPLPHNAG TPGSVPFNVG ALNTTKIYST 

       790        800        810        820        830        840 
NIKNLTLPNP KDAILVLSLS GEGHLPNSDK KTTFTHQNHF TPVFPKDLAL VDPGLELSYN 

       850        860        870        880        890        900 
TKSKTFTVEA KSGVSLYTWL DYPADVVGYF DENAFVLLPG QKKEIGFTVQ EDNTDGKWVQ 

       910 
GVTVQSLWNQ TLEK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007154 Genomic DNA. Translation: BAE57065.1.

3D structure databases

ProteinModelPortalQ2UN00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00000499.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00000510; CADAORAP00000499; CADAORAG00000510.

Phylogenomic databases

eggNOGCOG3250.
HOGENOMHOG000216059.
OMACHATQLF.
OrthoDBEOG78D7TH.

Enzyme and pathway databases

UniPathwayUPA00280.

Family and domain databases

Gene3D2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANBA_ASPOR
AccessionPrimary (citable) accession number: Q2UN00
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries