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Q2UN00

- MANBA_ASPOR

UniProt

Q2UN00 - MANBA_ASPOR

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Protein
Beta-mannosidase A
Gene
mndA, AO090001000556
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei462 – 4621Proton donor By similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:AO090001000556
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 2

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 914894Beta-mannosidase A
PRO_0000394647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi230 – 2301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi591 – 5911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi614 – 6141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi641 – 6411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi721 – 7211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi744 – 7441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi773 – 7731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi784 – 7841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi909 – 9091N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi5062.CADAORAP00000499.

Structurei

3D structure databases

ProteinModelPortaliQ2UN00.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000216059.
OMAiCHATQLF.
OrthoDBiEOG78D7TH.

Family and domain databases

Gene3Di2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UN00-1 [UniParc]FASTAAdd to Basket

« Hide

MRFTATAAAL VASSIPATLG QHVRDLSNEK WTLSSDALNH TVPGNLPSHA    50
HLDLLKAGVI DDPYHGLNDF NLRWIPESNW TYTTDKIKDL MPIEFCGKYV 100
ASTNNQYRQY SFDVSQILEG CNEDPILKID FGSAPNIVNA IAEDRNSPVW 150
PDGIQQTYEY PNRWFMRKEQ SDFGWDWGPA FAPAGPWKPA YIVQLPKAQN 200
IHVLNTDLDI YRKGQINHLP PDQSQPWVVN ASIDFVGSLP PNPSMSIEFK 250
DTKSGEILTS KRIGNVTVSG NSVTGVTVLG GVTPKLWWPL GLGDQNLYNI 300
TVTVTGHQNQ TLAHVTKRTG FRTIFLNQRN ITDAQLAQGI APGANWHFEV 350
NGHEFYAKGS NIIPPDAFWP RVTEARMARL FDAVVAGNQN MLRVWSSGIY 400
LHDFIYDLAD ERGILLWSEF EFSDALYPVD DAFLDNIAAE VVYNVRRVNH 450
HPSLALWAGG NEIESLMLPT VERKAPEEYA KYVGEYEKLY ISLILPLVYQ 500
NTRSITYSPS STTEGYLDVD LSAPVPMVER YHNTTPGSYY GDTDFYNYDS 550
SVSFNSHVYP VGRFANEFGY HSMPSLQTWQ QAVDPEDLHF NSTTVMLRNH 600
HYPAGGTFTD NFHNTSLGMG EMTIAVQRYY PIPNKLDSVA NFSAWCHATQ 650
LFQADMYKSE IQFYRRGSGM PERQLGSLYW QLEDIWQAPS WAGIEYGGRW 700
KVLHYVSRDI YQPIIVSPFW NYTTGDLDLY VTSDLWESAK GKVNLTWLDL 750
SGTPLPHNAG TPGSVPFNVG ALNTTKIYST NIKNLTLPNP KDAILVLSLS 800
GEGHLPNSDK KTTFTHQNHF TPVFPKDLAL VDPGLELSYN TKSKTFTVEA 850
KSGVSLYTWL DYPADVVGYF DENAFVLLPG QKKEIGFTVQ EDNTDGKWVQ 900
GVTVQSLWNQ TLEK 914
Length:914
Mass (Da):102,870
Last modified:January 24, 2006 - v1
Checksum:iF56D1E1EFAC63821
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007154 Genomic DNA. Translation: BAE57065.1.

Genome annotation databases

EnsemblFungiiCADAORAT00000510; CADAORAP00000499; CADAORAG00000510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007154 Genomic DNA. Translation: BAE57065.1 .

3D structure databases

ProteinModelPortali Q2UN00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00000499.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00000510 ; CADAORAP00000499 ; CADAORAG00000510 .

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000216059.
OMAi CHATQLF.
OrthoDBi EOG78D7TH.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

Gene3Di 2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiMANBA_ASPOR
AccessioniPrimary (citable) accession number: Q2UN00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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