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Q2UMV7

- EXGD_ASPOR

UniProt

Q2UMV7 - EXGD_ASPOR

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Protein

Probable glucan 1,3-beta-glucosidase D

Gene
exgD, AO090001000604
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei597 – 5971Proton donor By similarity
Active sitei702 – 7021Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:AO090001000604
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 297297Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei298 – 31821Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini319 – 831513Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Probable glucan 1,3-beta-glucosidase DPRO_0000395166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi376 – 3761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi442 – 4421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi558 – 5581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi610 – 6101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi636 – 6361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi669 – 6691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi689 – 6891N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00000542.

Structurei

3D structure databases

ProteinModelPortaliQ2UMV7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 161156Arg-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OrthoDBiEOG7ZPNTV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2UMV7-1 [UniParc]FASTAAdd to Basket

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MPSHSRSRDR YRSERDPSRR YREVYDDDDD DDFDYHPRER RRYRRDDYQH    50
DIRSHESPNY NDDLNEYDAA AEDPAVPLRS HDVEGRRRER SRAGESPIAS 100
PSRRDRNRGG EEYRRHGTYG DGGSPTRAMR DRRHRSRDGQ RARPRDMDRE 150
ARRQRRRERA RGAAAMKHKS SDSTNSGSHL LSADALAKLR SHYDEEDQRE 200
RSQEQEQPRM ESKRQRKRPI VGDEPQALAP FPDETPRGQS KGRIVSGAYL 250
EEGHPEMEVR HRGGGGPAME ARWRKEGNWD GTMEGSDAQP PFWKRKKWWI 300
VIGVLVVVLA IVIPVAVVMS KKHGHDDDKS GSSSSVDNSD SPYISSLDGL 350
SHDSIPESAQ GSILDPWTWY DTRDFNLTFT NETVGGLPIM GLNSTWDDST 400
RPNDNVPPLN ESFPYGSQPI RGVNLGGWLS IEPFIVPSLF ENYSSKDRII 450
DEYTLCKKLG SSAASTIEKH YADFISEQDF IDMRDAGLDH VRIQFSYWAV 500
TTYDDDPYVA KISWRYLLRA IEYCRKYGLR VNLDPHGIPG SQNGWNHSGR 550
EGVIGWLNGT DGQLNRQRSL DFHNQISQFF AQPRYKNVVT IYGLVNEPLM 600
LSLPVEDVLN WTTDATKLVQ KNGISAYVTV HDGFLNLSKW KQMLKDRPDR 650
MFLDTHQYTI FNTGQIVLNH TDRVKLICND WYNMIKEINT TSAGWGPTIC 700
GEWSQADTDC AQYLNNVGRG TRWEGTFAIG DSTVYCPTAD TGPTCSCASA 750
NAPPADYSDG YKKFLQTYAE AQMSAFGTAQ GWFYWTWHTE SAAQWSYKTA 800
WKNGYMPKKA YAPDFKCGDD IPSFGDLPEY Y 831
Length:831
Mass (Da):95,127
Last modified:June 15, 2010 - v2
Checksum:i26359FD8943FF6DB
GO

Sequence cautioni

The sequence BAE57108.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007154 Genomic DNA. Translation: BAE57108.1. Different initiation.
RefSeqiXP_001819110.2. XM_001819058.2.

Genome annotation databases

GeneIDi5991081.
KEGGiaor:AOR_1_1082164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007154 Genomic DNA. Translation: BAE57108.1 . Different initiation.
RefSeqi XP_001819110.2. XM_001819058.2.

3D structure databases

ProteinModelPortali Q2UMV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00000542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5991081.
KEGGi aor:AOR_1_1082164.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OrthoDBi EOG7ZPNTV.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiEXGD_ASPOR
AccessioniPrimary (citable) accession number: Q2UMV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: February 19, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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