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Protein

Probable glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei597Proton donorBy similarity1
Active sitei702NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:AO090001000604
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 297CytoplasmicSequence analysisAdd BLAST297
Transmembranei298 – 318Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini319 – 831ExtracellularSequence analysisAdd BLAST513

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003951661 – 831Probable glucan 1,3-beta-glucosidase DAdd BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi610N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi669N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi689N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00000542.

Structurei

3D structure databases

ProteinModelPortaliQ2UMV7.
SMRiQ2UMV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 161Arg-richAdd BLAST156

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000114462.
KOiK01210.
OrthoDBiEOG092C22A6.

Family and domain databases

InterProiView protein in InterPro
IPR001547. Glyco_hydro_5.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00150. Cellulase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2UMV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSHSRSRDR YRSERDPSRR YREVYDDDDD DDFDYHPRER RRYRRDDYQH
60 70 80 90 100
DIRSHESPNY NDDLNEYDAA AEDPAVPLRS HDVEGRRRER SRAGESPIAS
110 120 130 140 150
PSRRDRNRGG EEYRRHGTYG DGGSPTRAMR DRRHRSRDGQ RARPRDMDRE
160 170 180 190 200
ARRQRRRERA RGAAAMKHKS SDSTNSGSHL LSADALAKLR SHYDEEDQRE
210 220 230 240 250
RSQEQEQPRM ESKRQRKRPI VGDEPQALAP FPDETPRGQS KGRIVSGAYL
260 270 280 290 300
EEGHPEMEVR HRGGGGPAME ARWRKEGNWD GTMEGSDAQP PFWKRKKWWI
310 320 330 340 350
VIGVLVVVLA IVIPVAVVMS KKHGHDDDKS GSSSSVDNSD SPYISSLDGL
360 370 380 390 400
SHDSIPESAQ GSILDPWTWY DTRDFNLTFT NETVGGLPIM GLNSTWDDST
410 420 430 440 450
RPNDNVPPLN ESFPYGSQPI RGVNLGGWLS IEPFIVPSLF ENYSSKDRII
460 470 480 490 500
DEYTLCKKLG SSAASTIEKH YADFISEQDF IDMRDAGLDH VRIQFSYWAV
510 520 530 540 550
TTYDDDPYVA KISWRYLLRA IEYCRKYGLR VNLDPHGIPG SQNGWNHSGR
560 570 580 590 600
EGVIGWLNGT DGQLNRQRSL DFHNQISQFF AQPRYKNVVT IYGLVNEPLM
610 620 630 640 650
LSLPVEDVLN WTTDATKLVQ KNGISAYVTV HDGFLNLSKW KQMLKDRPDR
660 670 680 690 700
MFLDTHQYTI FNTGQIVLNH TDRVKLICND WYNMIKEINT TSAGWGPTIC
710 720 730 740 750
GEWSQADTDC AQYLNNVGRG TRWEGTFAIG DSTVYCPTAD TGPTCSCASA
760 770 780 790 800
NAPPADYSDG YKKFLQTYAE AQMSAFGTAQ GWFYWTWHTE SAAQWSYKTA
810 820 830
WKNGYMPKKA YAPDFKCGDD IPSFGDLPEY Y
Length:831
Mass (Da):95,127
Last modified:June 15, 2010 - v2
Checksum:i26359FD8943FF6DB
GO

Sequence cautioni

The sequence BAE57108 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007154 Genomic DNA. Translation: BAE57108.1. Different initiation.
RefSeqiXP_001819110.2. XM_001819058.2.

Genome annotation databases

EnsemblFungiiBAE57108; BAE57108; AO090001000604.
GeneIDi5991081.
KEGGiaor:AOR_1_1082164.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEXGD_ASPOR
AccessioniPrimary (citable) accession number: Q2UMV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 5, 2017
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families