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Protein

Histone acetyltransferase ESA1

Gene

esa1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei360Important for catalytic activityBy similarity1
Active sitei394Proton donor/acceptorBy similarity1
Binding sitei398Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 276C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase ESA1 (EC:2.3.1.48By similarity)
Gene namesi
Name:esa1
ORF Names:AO090001000664
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340781 – 506Histone acetyltransferase ESA1Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-318 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ2UMQ5

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Protein-protein interaction databases

STRINGi5062.CADAORAP00000594

Structurei

3D structure databases

ProteinModelPortaliQ2UMQ5
SMRiQ2UMQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 95ChromoAdd BLAST57
Domaini218 – 494MYST-type HATPROSITE-ProRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni359 – 363Acetyl-CoA bindingBy similarity5
Regioni368 – 374Acetyl-CoA bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi301 – 322ESA1-RPD3 motifAdd BLAST22

Domaini

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 276C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Phylogenomic databases

HOGENOMiHOG000182457
KOiK11304
OMAiIRPWYFS
OrthoDBiEOG092C043Q

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR037995 Esa1/KAT5/Tip60
IPR002717 HAT_MYST-type
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR10615:SF124 PTHR10615:SF124, 1 hit
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q2UMQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRDSHGEA TATPDPVEKG FATLNTIRIG VKAMVQKDGE LRKAEILSIR
60 70 80 90 100
QRKDGPSFYV HYVDFNKRLD EWIDSTRIDL SHEVEWPQPE KPEKKKAGPG
110 120 130 140 150
NKAPSKNAQK RARAGSREVS ATPDLLTGKN TNIGKAQRPS KAGGKENRDE
160 170 180 190 200
TPANLSVLDS EAISADVTPK PEMEDVDMIG VSFTDTKEEH EQGKMSREEE
210 220 230 240 250
IERLRTSGSM TQNPTEIHRV RNLNRLQMGK FDIEPWYFSP YPASFSDVDM
260 270 280 290 300
VYIDEFCLSY FDNKRAFERH RSKCTLVHPP GNEIYRDDRI SFFEVDGRRQ
310 320 330 340 350
RTWCRNLCLL SKLFLDHKTL YYDVDPFLFY CMATRDETGC HLVGYFSKEK
360 370 380 390 400
DSAEGYNLAC ILTLPQYQRL GYGRLLIAFS YELSKREGKL GSPEKPLSDL
410 420 430 440 450
GLLSYRQYWR ETLVELLIEP GRESMSENEL AVLTSMTEKD VHETLVVFNM
460 470 480 490 500
LRYHKGNWVI VLTDQVVEQH NKRLEKEKIK GSRKIDPARL QWKPPVFTAS

SRTWNW
Length:506
Mass (Da):58,335
Last modified:January 24, 2006 - v1
Checksum:iB7FE46EDE0DA5846
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007154 Genomic DNA Translation: BAE57160.1
RefSeqiXP_001819162.1, XM_001819110.2

Genome annotation databases

EnsemblFungiiBAE57160; BAE57160; AO090001000664
GeneIDi5991133
KEGGiaor:AO090001000664

Similar proteinsi

Entry informationi

Entry nameiESA1_ASPOR
AccessioniPrimary (citable) accession number: Q2UMQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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