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Protein

Probable catabolite repression protein creC

Gene

creC

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable catabolite repression protein creC
Gene namesi
Name:creC
ORF Names:AO090003000149
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiFungiDB:AO090003000149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Probable catabolite repression protein creCPRO_0000395691Add
BLAST

Interactioni

Subunit structurei

Interacts with creB.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2UM42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati226 – 26641WD 1Add
BLAST
Repeati306 – 34742WD 2Add
BLAST
Repeati348 – 38740WD 3Add
BLAST
Repeati390 – 43445WD 4Add
BLAST
Repeati506 – 54338WD 5Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat creC family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000215532.
OMAiVIMGFST.
OrthoDBiEOG7MD4ZS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UM42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGPSCASE LHYYRALDHA NAGFATGTYH LKDDLHLATP PPHPSEAPVV
60 70 80 90 100
NPNPLATVPT PPTSGVKLSL VSVGQRNKLP VFTSKEKVTA PPFADGNPAL
110 120 130 140 150
AAIPTKDGLK RRKPKNNIIK SSSSFVSRVI THEASSKRLN DRNPDGLFAF
160 170 180 190 200
ANINRAFQWL DLSSKNKEEP LAKILFTKAH MLTHDINELT KSSSHIDIAM
210 220 230 240 250
GSSAGDIIWY EPISQKYARI NKNGVVSNSP VTHIKWIPGS ENMFMAAHAN
260 270 280 290 300
GQLVVYDKEK EDALFTPEIS NHSAEAMKAS SRLPLQVLKS VNSRNQKTNP
310 320 330 340 350
VALWKLANQK ISQFAFSPDQ RHLAVVLEDG SLRVMDYLKE EVLDIFRSYY
360 370 380 390 400
GGLICVCWSP DGKYIVTGGQ DDLVTIWSFP ERKIVARCQG HNSWVSTVAF
410 420 430 440 450
DPWRCDERTY RFGSVGDDCR LLLWDFSVGM LHRPRAHQAS ARQRTSMIAS
460 470 480 490 500
NTQHFNRHRA DSASNRMRSD SQRTADTYND YDSAVRHPVE PRARTALLPP
510 520 530 540 550
IMSKIVGDDP ICWLGFQEDS IMTSSLEGHI RTWDRPREGI NDSYNGNTSS
560 570
PAISTSAAGS GSGIADSAMG SL
Length:572
Mass (Da):63,235
Last modified:January 24, 2006 - v1
Checksum:iF13E38A0C43B474E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007155 Genomic DNA. Translation: BAE57373.1.

Genome annotation databases

EnsemblFungiiCADAORAT00000823; CADAORAP00000807; CADAORAG00000823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007155 Genomic DNA. Translation: BAE57373.1.

3D structure databases

ProteinModelPortaliQ2UM42.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00000823; CADAORAP00000807; CADAORAG00000823.

Organism-specific databases

EuPathDBiFungiDB:AO090003000149.

Phylogenomic databases

HOGENOMiHOG000215532.
OMAiVIMGFST.
OrthoDBiEOG7MD4ZS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiCREC_ASPOR
AccessioniPrimary (citable) accession number: Q2UM42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 24, 2006
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.