Reviewed, UniProtKB/Swiss-Prot Q2UM19 (MCES_ASPOR)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	abd1
ORF Names:	AO090003000177

Organism

Aspergillus oryzae [Complete proteome]

Taxonomic identifier

5062 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	mRNA cap guanine-N7 methyltransferase		PRO_0000303904

Sequences

	Sequence		Length	Mass (Da)
	Q2UM19-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 4F7A498659298DC8	FASTA	502	56,971
	10 20 30 40 50 60 MADENPQAQG AEGGGKGKSS SMRLQERHQQ LRKRGRTPPS AYARRDMNET AQQHNRNESS 70 80 90 100 110 120 NRSPSPLAPP RSPSPDAQAR KRKRPGGGAR MGLVDRETLR RRQEERERSQ QEEAMRFSQN 130 140 150 160 170 180 RGVTDIVRHH YNAVPQRGRE WRKTESKIKG LRSFNNWIKS TLIQKFSPDE EFVARSIGTK 190 200 210 220 230 240 DWADETAPPP MEDKRLLVVD LGCGKGGDLG KWQLAPQPVD LYVGLDPAEV SIVQARERYN 250 260 270 280 290 300 GMRTGRGPRG RRGPLFHAEF APKDCFGEYL GDVPIVQQVG IDPNAGPGGS VMSSRWGGGG 310 320 330 340 350 360 FDVVASMFTI HYAFESEEKA RQMLRNVAGC LKKGGRFLGV CPNSDIISAR VAEMNAKRKE 370 380 390 400 410 420 RETAAKKEEA EPEDGEVEED DNKIEWGNSI YRVRFSGDTP EDGIFRPPFG WKYSYFMEEA 430 440 450 460 470 480 VEEIPEYVVP WEAFRALTED YNLELQYRKP FLEVWKDEKD DQELGPLSER MGVRDRNTGA 490 500 LLMTEEEKEA ASFYHAFCFY KV

References

[1]

"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed: 16372010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP007155 Genomic DNA. Translation: BAE57396.1.
RefSeq	XP_001819398.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5991381.
KEGG	aor:AO090003000177.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCES_ASPOR

Accession

Primary (citable) accession number: Q2UM19

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 24, 2006
Last modified:	November 25, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)