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Protein

Iron-sulfur clusters transporter atm1, mitochondrial

Gene

atm1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei409Glutathione; via amide nitrogenBy similarity1
Binding sitei461ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi485 – 496ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter atm1, mitochondrial
Gene namesi
Name:atm1
ORF Names:AO090003000411
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 126Mitochondrial matrixBy similarityAdd BLAST77
Transmembranei127 – 148HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini149 – 171Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei172 – 195HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini196 – 244Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei245 – 268HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini269Mitochondrial intermembraneBy similarity1
Transmembranei270 – 290HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini291 – 356Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei357 – 375HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini376 – 390Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei391 – 412HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini413 – 720Mitochondrial matrixBy similarityAdd BLAST308

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
ChainiPRO_000025543950 – 720Iron-sulfur clusters transporter atm1, mitochondrialAdd BLAST671

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5062.CADAORAP00001025.

Structurei

3D structure databases

ProteinModelPortaliQ2ULH4.
SMRiQ2ULH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 417ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini452 – 688ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni296 – 300Glutathione bindingBy similarity5
Regioni359 – 362Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK05663.
OMAiYEAQRYD.
OrthoDBiEOG092C3H79.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2ULH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRAARPPC LRVPGHFAHR GPAVPRSTPR ISTRHSIQFR VFSTSKGLLN
60 70 80 90 100
KNATSEPKTP ISGSPLAPQS ADQKTKNAQN AAGTPKRDLL SETMVGKQEQ
110 120 130 140 150
RKADWAIMKE MAKYLWPKDD WGTKLRVGTA LSLLVGAKIL NVNVPFYFKS
160 170 180 190 200
IVDSMNVDFA AIGGTAYTVA GSMIIAYGVT RIGATLFQEL RNAVFASVAQ
210 220 230 240 250
KAIRRVARNV FEHLLRLDLN FHLSRQTGGL TRAIDRGTKG ISFLLTSMVF
260 270 280 290 300
HVVPTALEIS LVCGILTYQY GAQFAAITAA TMVAYSAFTI TTTAWRTKFR
310 320 330 340 350
KQANAADNRG ATVAVDSLIN YEAVKYFNNE KFEVARYDKA LKAYEDASIK
360 370 380 390 400
VTTSLAFLNS GQNMIFSSAL AGMMYLAANG VASGSLTVGD LVMVNQLVFQ
410 420 430 440 450
LSVPLNFLGS VYRELRQSLL DMETLFNLQK VNVNITEKPN AKPLQLHRGG
460 470 480 490 500
EIKFENVTFG YHPDRPILKN ASFTIPAGQK FAIVGPSGCG KSTILRLLFR
510 520 530 540 550
YYDVQEGRIL VDGQDVRDVT LESLRKAIGV VPQDTPLFND SIAHNIRYGR
560 570 580 590 600
IDATDEEVRK AAQRAHIHEL IEKLPEGYKT AVGERGMMIS GGEKQRLAIS
610 620 630 640 650
RLILKDPELL FFDEATSALD TYTEQALLQN INSVLKDKAR TSVFVAHRLR
660 670 680 690 700
TICDSDQILV LKEGRVAETG SHRELLELDG IYAELWNAQE MSFAQDPESE
710 720
GNAELEEGAG QEVLPDSRQK
Length:720
Mass (Da):79,459
Last modified:January 24, 2006 - v1
Checksum:i95354EA6BA2EAEC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007155 Genomic DNA. Translation: BAE57591.1.
RefSeqiXP_001819593.1. XM_001819541.2.

Genome annotation databases

EnsemblFungiiBAE57591; BAE57591; AO090003000411.
GeneIDi5991576.
KEGGiaor:AOR_1_706154.

Similar proteinsi

Entry informationi

Entry nameiATM1_ASPOR
AccessioniPrimary (citable) accession number: Q2ULH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 24, 2006
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families