Q2UKP9 (Q2UKP9_ASPOR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Homoserine dehydrogenase RuleBase RU000579
EC=1.1.1.3 RuleBase RU000579

Gene names

ORF Names:

AO090003000721 EMBL BAE57866.1

Organism

Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome] EMBL BAE57866.1

Taxonomic identifier

510516 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus oryzae

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H. RuleBase RU000579
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. RuleBase RU000579 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. RuleBase RU000579
Sequence similarities	Belongs to the homoserine dehydrogenase family. RuleBase RU004171

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis RuleBase RU000579 Methionine biosynthesis RuleBase RU000579 Threonine biosynthesis RuleBase RU000579
Ligand	NADP RuleBase RU000579 PIRSR PIRSR036497-2
Molecular function	Oxidoreductase RuleBase RU000579
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	11 – 16	6	NADP By similarity PIRSR PIRSR036497-2
Sites
	Active site	227	1	Proton donor By similarity PIRSR PIRSR036497-1
	Binding site	95	1	NADP By similarity PIRSR PIRSR036497-2
	Binding site	119	1	NADP By similarity PIRSR PIRSR036497-2
	Binding site	212	1	Substrate By similarity PIRSR PIRSR036497-2

Sequences

	Sequence		Length	Mass (Da)
	Q2UKP9 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 53DDA041D2806FD6	FASTA	369	38,934
	10 20 30 40 50 60 MSNPVYLGVI GVGGVGTAFL SQLARLPNAP KLVLLARSSQ TLQSPTPAYS PAIPAADWKT 70 80 90 100 110 120 AVETPSLIKS GALSVDEIAS YLSSAPGRSI LVDNTSDLTL ASSYPVFLRK GISIVTPNKK 130 140 150 160 170 180 GFSSDLSLWK DIFAAAAEGK ALVYHESTVG AGLPVISTLR DLVSTGDEVT RIEGVFSGTL 190 200 210 220 230 240 SFLFNTFAPV SGPSGAKWSE VVAKAKELGY TEPDPRDDLN GMDVARKLTI LARIAGLEVQ 250 260 270 280 290 300 SPDSFPIESL IPKELESVPS TADGIKEFMT RLPEFDGQMS AIKEAAEKEG KVVRYVGSVD 310 320 330 340 350 360 VGKKEVRVGL QYFDKDSSIA GLKGSDNIIS FYTKRYGGNP LVVQGSGAGG DVTAMGVSAD LIKVVQRLQ

References

[1]

"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP007155 Genomic DNA. Translation: BAE57866.1.
RefSeq	XP_001819868.1. XM_001819816.2.
3D structure databases
ProteinModelPortal	Q2UKP9.
SMR	Q2UKP9. Positions 2-368.
ModBase	Search...
Protein-protein interaction databases
STRING	5062.CADAORAP00001300.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAORAT00001319; CADAORAP00001300; CADAORAG00001319.
GeneID	5991851.
KEGG	aor:AOR_1_1276154.
Phylogenomic databases
HOGENOM	HOG000024037.
KO	K00003.
OrthoDB	EOG4X6GJ2.
Enzyme and pathway databases
UniPathway	UPA00050; UER00063. UPA00051; UER00465.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR005106. Asp/hSer_DH_NAD-bd. IPR001342. HDH_cat. IPR019811. HDH_CS. IPR022697. HDH_short. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF036497. HDH_short. 1 hit.
PROSITE	PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2UKP9_ASPOR

Accession

Primary (citable) accession number: Q2UKP9

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)