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Q2UKP9

- Q2UKP9_ASPOR

UniProt

Q2UKP9 - Q2UKP9_ASPOR

Protein

Homoserine dehydrogenase

Gene

AO090003000721

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951NADPUniRule annotation
    Binding sitei119 – 1191NADPUniRule annotation
    Binding sitei212 – 2121SubstrateUniRule annotation
    Active sitei227 – 2271Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADPUniRule annotation

    GO - Molecular functioni

    1. homoserine dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-KW
    2. methionine biosynthetic process Source: UniProtKB-KW
    3. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00063.
    UPA00051; UER00465.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    ORF Names:AO090003000721Imported
    OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)Imported
    Taxonomic identifieri510516 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006564: Chromosome 2

    Interactioni

    Protein-protein interaction databases

    STRINGi5062.CADAORAP00001300.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2UKP9.
    SMRiQ2UKP9. Positions 2-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homoserine dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000024037.
    KOiK00003.
    OMAiHANAAPR.
    OrthoDBiEOG7BGHWP.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR001342. HDH_cat.
    IPR019811. HDH_CS.
    IPR022697. HDH_short.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00742. Homoserine_dh. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036497. HDH_short. 1 hit.
    PROSITEiPS01042. HOMOSER_DHGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2UKP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNPVYLGVI GVGGVGTAFL SQLARLPNAP KLVLLARSSQ TLQSPTPAYS    50
    PAIPAADWKT AVETPSLIKS GALSVDEIAS YLSSAPGRSI LVDNTSDLTL 100
    ASSYPVFLRK GISIVTPNKK GFSSDLSLWK DIFAAAAEGK ALVYHESTVG 150
    AGLPVISTLR DLVSTGDEVT RIEGVFSGTL SFLFNTFAPV SGPSGAKWSE 200
    VVAKAKELGY TEPDPRDDLN GMDVARKLTI LARIAGLEVQ SPDSFPIESL 250
    IPKELESVPS TADGIKEFMT RLPEFDGQMS AIKEAAEKEG KVVRYVGSVD 300
    VGKKEVRVGL QYFDKDSSIA GLKGSDNIIS FYTKRYGGNP LVVQGSGAGG 350
    DVTAMGVSAD LIKVVQRLQ 369
    Length:369
    Mass (Da):38,934
    Last modified:January 24, 2006 - v1
    Checksum:i53DDA041D2806FD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007155 Genomic DNA. Translation: BAE57866.1.
    RefSeqiXP_001819868.1. XM_001819816.2.

    Genome annotation databases

    EnsemblFungiiCADAORAT00001319; CADAORAP00001300; CADAORAG00001319.
    GeneIDi5991851.
    KEGGiaor:AOR_1_1276154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007155 Genomic DNA. Translation: BAE57866.1 .
    RefSeqi XP_001819868.1. XM_001819816.2.

    3D structure databases

    ProteinModelPortali Q2UKP9.
    SMRi Q2UKP9. Positions 2-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5062.CADAORAP00001300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAORAT00001319 ; CADAORAP00001300 ; CADAORAG00001319 .
    GeneIDi 5991851.
    KEGGi aor:AOR_1_1276154.

    Phylogenomic databases

    HOGENOMi HOG000024037.
    KOi K00003.
    OMAi HANAAPR.
    OrthoDBi EOG7BGHWP.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00063 .
    UPA00051 ; UER00465 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR001342. HDH_cat.
    IPR019811. HDH_CS.
    IPR022697. HDH_short.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00742. Homoserine_dh. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036497. HDH_short. 1 hit.
    PROSITEi PS01042. HOMOSER_DHGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of Aspergillus oryzae."
      Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
      , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
      Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42149 / RIB 40Imported.

    Entry informationi

    Entry nameiQ2UKP9_ASPOR
    AccessioniPrimary (citable) accession number: Q2UKP9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3