SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2UKP9

- Q2UKP9_ASPOR

UniProt

Q2UKP9 - Q2UKP9_ASPOR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homoserine dehydrogenase

Gene
AO090003000721
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951NADP By similarityUniRule annotation
Binding sitei119 – 1191NADP By similarityUniRule annotation
Binding sitei212 – 2121Substrate By similarityUniRule annotation
Active sitei227 – 2271Proton donor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADP By similarityUniRule annotation

GO - Molecular functioni

  1. homoserine dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-KW
  2. methionine biosynthetic process Source: UniProtKB-KW
  3. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
ORF Names:AO090003000721Imported
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)Imported
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00001300.

Structurei

3D structure databases

ProteinModelPortaliQ2UKP9.
SMRiQ2UKP9. Positions 2-368.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000024037.
KOiK00003.
OMAiHANAAPR.
OrthoDBiEOG7BGHWP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR022697. HDH_short.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036497. HDH_short. 1 hit.
PROSITEiPS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UKP9-1 [UniParc]FASTAAdd to Basket

« Hide

MSNPVYLGVI GVGGVGTAFL SQLARLPNAP KLVLLARSSQ TLQSPTPAYS    50
PAIPAADWKT AVETPSLIKS GALSVDEIAS YLSSAPGRSI LVDNTSDLTL 100
ASSYPVFLRK GISIVTPNKK GFSSDLSLWK DIFAAAAEGK ALVYHESTVG 150
AGLPVISTLR DLVSTGDEVT RIEGVFSGTL SFLFNTFAPV SGPSGAKWSE 200
VVAKAKELGY TEPDPRDDLN GMDVARKLTI LARIAGLEVQ SPDSFPIESL 250
IPKELESVPS TADGIKEFMT RLPEFDGQMS AIKEAAEKEG KVVRYVGSVD 300
VGKKEVRVGL QYFDKDSSIA GLKGSDNIIS FYTKRYGGNP LVVQGSGAGG 350
DVTAMGVSAD LIKVVQRLQ 369
Length:369
Mass (Da):38,934
Last modified:January 24, 2006 - v1
Checksum:i53DDA041D2806FD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007155 Genomic DNA. Translation: BAE57866.1.
RefSeqiXP_001819868.1. XM_001819816.2.

Genome annotation databases

EnsemblFungiiCADAORAT00001319; CADAORAP00001300; CADAORAG00001319.
GeneIDi5991851.
KEGGiaor:AOR_1_1276154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007155 Genomic DNA. Translation: BAE57866.1 .
RefSeqi XP_001819868.1. XM_001819816.2.

3D structure databases

ProteinModelPortali Q2UKP9.
SMRi Q2UKP9. Positions 2-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00001300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00001319 ; CADAORAP00001300 ; CADAORAG00001319 .
GeneIDi 5991851.
KEGGi aor:AOR_1_1276154.

Phylogenomic databases

HOGENOMi HOG000024037.
KOi K00003.
OMAi HANAAPR.
OrthoDBi EOG7BGHWP.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00063 .
UPA00051 ; UER00465 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR022697. HDH_short.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036497. HDH_short. 1 hit.
PROSITEi PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiQ2UKP9_ASPOR
AccessioniPrimary (citable) accession number: Q2UKP9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi