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Protein

Homoserine dehydrogenase

Gene

AO090003000721

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 3 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (AO090003000721), Homoserine dehydrogenase (AO090009000136)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (AO090003000721), Homoserine dehydrogenase (AO090009000136)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95NADPUniRule annotation1
Binding sitei119NADPUniRule annotation1
Binding sitei212SubstrateUniRule annotation1
Active sitei227Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Gene namesi
ORF Names:AO090003000721Imported
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)Imported
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 2

Structurei

3D structure databases

ProteinModelPortaliQ2UKP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 146NAD_binding_3InterPro annotationAdd BLAST136
Domaini154 – 362Homoserine_dhInterPro annotationAdd BLAST209

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000024037.
KOiK00003.
OMAiHANAAPR.
OrthoDBiEOG092C36D3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR022697. HDH_short.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036497. HDH_short. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UKP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPVYLGVI GVGGVGTAFL SQLARLPNAP KLVLLARSSQ TLQSPTPAYS
60 70 80 90 100
PAIPAADWKT AVETPSLIKS GALSVDEIAS YLSSAPGRSI LVDNTSDLTL
110 120 130 140 150
ASSYPVFLRK GISIVTPNKK GFSSDLSLWK DIFAAAAEGK ALVYHESTVG
160 170 180 190 200
AGLPVISTLR DLVSTGDEVT RIEGVFSGTL SFLFNTFAPV SGPSGAKWSE
210 220 230 240 250
VVAKAKELGY TEPDPRDDLN GMDVARKLTI LARIAGLEVQ SPDSFPIESL
260 270 280 290 300
IPKELESVPS TADGIKEFMT RLPEFDGQMS AIKEAAEKEG KVVRYVGSVD
310 320 330 340 350
VGKKEVRVGL QYFDKDSSIA GLKGSDNIIS FYTKRYGGNP LVVQGSGAGG
360
DVTAMGVSAD LIKVVQRLQ
Length:369
Mass (Da):38,934
Last modified:January 24, 2006 - v1
Checksum:i53DDA041D2806FD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007155 Genomic DNA. Translation: BAE57866.1.
RefSeqiXP_001819868.1. XM_001819816.2.

Genome annotation databases

EnsemblFungiiBAE57866; BAE57866; AO090003000721.
CADAORAT00001319; CADAORAP00001300; CADAORAG00001319.
GeneIDi5991851.
KEGGiaor:AOR_1_1276154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007155 Genomic DNA. Translation: BAE57866.1.
RefSeqiXP_001819868.1. XM_001819816.2.

3D structure databases

ProteinModelPortaliQ2UKP9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAE57866; BAE57866; AO090003000721.
CADAORAT00001319; CADAORAP00001300; CADAORAG00001319.
GeneIDi5991851.
KEGGiaor:AOR_1_1276154.

Phylogenomic databases

HOGENOMiHOG000024037.
KOiK00003.
OMAiHANAAPR.
OrthoDBiEOG092C36D3.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR022697. HDH_short.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036497. HDH_short. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ2UKP9_ASPOR
AccessioniPrimary (citable) accession number: Q2UKP9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.