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Protein

Homoserine dehydrogenase

Gene

AO090003000721

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951NADPUniRule annotation
Binding sitei119 – 1191NADPUniRule annotation
Binding sitei212 – 2121SubstrateUniRule annotation
Active sitei227 – 2271Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADPUniRule annotation

GO - Molecular functioni

  1. homoserine dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-KW
  2. methionine biosynthetic process Source: UniProtKB-KW
  3. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
ORF Names:AO090003000721Imported
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)Imported
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00001300.

Structurei

3D structure databases

ProteinModelPortaliQ2UKP9.
SMRiQ2UKP9. Positions 2-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000024037.
KOiK00003.
OMAiIPAGDWK.
OrthoDBiEOG7BGHWP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR022697. HDH_short.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036497. HDH_short. 1 hit.
PROSITEiPS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UKP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNPVYLGVI GVGGVGTAFL SQLARLPNAP KLVLLARSSQ TLQSPTPAYS
60 70 80 90 100
PAIPAADWKT AVETPSLIKS GALSVDEIAS YLSSAPGRSI LVDNTSDLTL
110 120 130 140 150
ASSYPVFLRK GISIVTPNKK GFSSDLSLWK DIFAAAAEGK ALVYHESTVG
160 170 180 190 200
AGLPVISTLR DLVSTGDEVT RIEGVFSGTL SFLFNTFAPV SGPSGAKWSE
210 220 230 240 250
VVAKAKELGY TEPDPRDDLN GMDVARKLTI LARIAGLEVQ SPDSFPIESL
260 270 280 290 300
IPKELESVPS TADGIKEFMT RLPEFDGQMS AIKEAAEKEG KVVRYVGSVD
310 320 330 340 350
VGKKEVRVGL QYFDKDSSIA GLKGSDNIIS FYTKRYGGNP LVVQGSGAGG
360
DVTAMGVSAD LIKVVQRLQ
Length:369
Mass (Da):38,934
Last modified:January 24, 2006 - v1
Checksum:i53DDA041D2806FD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007155 Genomic DNA. Translation: BAE57866.1.
RefSeqiXP_001819868.1. XM_001819816.2.

Genome annotation databases

EnsemblFungiiCADAORAT00001319; CADAORAP00001300; CADAORAG00001319.
GeneIDi5991851.
KEGGiaor:AOR_1_1276154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007155 Genomic DNA. Translation: BAE57866.1.
RefSeqiXP_001819868.1. XM_001819816.2.

3D structure databases

ProteinModelPortaliQ2UKP9.
SMRiQ2UKP9. Positions 2-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5062.CADAORAP00001300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00001319; CADAORAP00001300; CADAORAG00001319.
GeneIDi5991851.
KEGGiaor:AOR_1_1276154.

Phylogenomic databases

HOGENOMiHOG000024037.
KOiK00003.
OMAiIPAGDWK.
OrthoDBiEOG7BGHWP.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR022697. HDH_short.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036497. HDH_short. 1 hit.
PROSITEiPS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40Imported.

Entry informationi

Entry nameiQ2UKP9_ASPOR
AccessioniPrimary (citable) accession number: Q2UKP9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.