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Q2UHA7 (NCPR_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADPH--cytochrome P450 reductase

Short name=CPR
Short name=P450R
EC=1.6.2.4
Gene names
Name:cprA
ORF Names:AO090023000520
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis By similarity.

Catalytic activity

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.

Cofactor

FAD By similarity.

FMN By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Cell membrane; Single-pass membrane protein By similarity. Microsome By similarity.

Sequence similarities

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Contains 1 FAD-binding FR-type domain.

Contains 1 flavodoxin-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695NADPH--cytochrome P450 reductase
PRO_0000404330

Regions

Transmembrane9 – 3123Helical; Potential
Domain66 – 221156Flavodoxin-like
Domain277 – 538262FAD-binding FR-type
Nucleotide binding72 – 765FMN By similarity
Nucleotide binding166 – 19732FMN By similarity
Nucleotide binding317 – 32812FAD By similarity
Nucleotide binding447 – 45812FAD By similarity
Nucleotide binding547 – 56519NADP By similarity
Nucleotide binding642 – 65817NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2UHA7 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 4C7A78DE7B4F2B63

FASTA69576,637
        10         20         30         40         50         60 
MAQLDTLDLV VLVALLVGSV AYFTKGTYWA VAKDPYASSG PAMNGAAKAG KTRDILEKME 

        70         80         90        100        110        120 
ETGKNCVIFY GSQTGTAEDY ASRLAKEGSQ RFGLKTMVAD LEDYDYENLD KFPEDKVAFF 

       130        140        150        160        170        180 
VLATYGEGEP TDNAVEFYQF ITGEDVAFES GASAEEKPLS ALKYVTFGLG NNTYEHYNAM 

       190        200        210        220        230        240 
VRNLDAALQK LGAQRIGSAG EGDDGAGTME EDFLAWKEPM WTALSEAMGL QEREAVYEPV 

       250        260        270        280        290        300 
FNVTEDESKS AEDETVYLGE PTKGHLEGQP KGPFSAHNPF IAPIVESREL FTVKDRNCLH 

       310        320        330        340        350        360 
MEISIAGSNL TYQTGDHIAV WPTNAGAEVD RFLQVFGLEE KRHSVINIKG IDVTAKVPIP 

       370        380        390        400        410        420 
TPTTYDAAVR YYMEVCAPVS RQFVSSLAAF APDEATKTEI QRLGSDKDYF HEKITNQCFN 

       430        440        450        460        470        480 
IAQALQSITS KPFSAVPFSL LIEGLNKLQP RYYSISSSSL VQKDKISITA VVESVRLPGA 

       490        500        510        520        530        540 
SHLVKGVTTN YLLALKQKQN GEPSPDPHGL TYAITGPRNK YDGIHVPVHV RHSNFKLPSD 

       550        560        570        580        590        600 
PSRPIIMVGP GTGVAPFRGF IQERAALAAK GEKVGTTVLF FGCRNRNEDF LYQDEFKAYE 

       610        620        630        640        650        660 
EQLGDSLKII TAFSRETSQK VYVQHRLREQ AELVSDLLKQ KATFYVCGDA ANMAREVNLV 

       670        680        690 
LGQIIAQQRG LPAEKGEEMV KHMRSSGSYQ EDVWS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007157 Genomic DNA. Translation: BAE59058.1.
RefSeqXP_001821060.1. XM_001821008.2.

3D structure databases

ProteinModelPortalQ2UHA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00007484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00007638; CADAORAP00007484; CADAORAG00007638.
GeneID5993062.
KEGGaor:AOR_1_894144.

Phylogenomic databases

eggNOGCOG0369.
HOGENOMHOG000282027.
KOK00327.
OMAEFGAMEH.
OrthoDBEOG744TKC.

Family and domain databases

Gene3D1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFPIRSF000208. P450R. 1 hit.
PRINTSPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNCPR_ASPOR
AccessionPrimary (citable) accession number: Q2UHA7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families