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Q2UH35

- DPP4_ASPOR

UniProt

Q2UH35 - DPP4_ASPOR

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Protein
Dipeptidyl peptidase 4
Gene
dpp4, AO090023000602
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.1 Publication

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

pH dependencei

Optimum pH is 7.0. is active between pH 4.0 and 9.0.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei618 – 6181Charge relay system By similarity
Active sitei695 – 6951Charge relay system By similarity
Active sitei730 – 7301Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: ASPGD
  3. serine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis Source: ASPGD
  2. proteolysis involved in cellular protein catabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:AO090023000602
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 3

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 771755Dipeptidyl peptidase 4
PRO_5000064328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi470 – 4701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi495 – 4951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00007556.

Structurei

3D structure databases

ProteinModelPortaliQ2UH35.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiWAVNYTK.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UH35-1 [UniParc]FASTAAdd to Basket

« Hide

MKYSKLLLLL VSVVQALDVP RKPHAPTGEG SKRLTFNETV VKQAITPTSR    50
SVQWLSGAED GSYVYAAEDG SLTIENIVTN ESRTLIPADK IPTGKEAFNY 100
WIHPDLSSVL WASNHTKQYR HSFFADYYVQ DVESLKSVPL MPDQEGDIQY 150
AQWSPVGNTI AFVRENDLYV WDNGTVTRIT DDGGPDMFHG VPDWIYEEEI 200
LGDRYALWFS PDGEYLAYLS FNETGVPTYT VQYYMDNQEI APAYPWELKI 250
RYPKVSQTNP TVTLSLLNIA SKEVKQAPID AFESTDLIIG EVAWLTDTHT 300
TVAAKAFNRV QDQQKVVAVD TASNKATVIS DRDGTDGWLD NLLSMKYIGP 350
IKPSDKDAYY IDISDHSGWA HLYLFPVSGG EPIPLTKGDW EVTSILSIDQ 400
ERQLVYYLST QHHSTERHLY SVSYSTFAVT PLVDDTVAAY WSASFSANSG 450
YYILTYGGPD VPYQELYTTN STKPLRTITD NAKVLEQIKD YALPNITYFE 500
LPLPSGETLN VMQRLPPGFS PDKKYPILFT PYGGPGAQEV TKRWQALNFK 550
AYVASDSELE YVTWTVDNRG TGFKGRKFRS AVTRQLGLLE AEDQIYAAQQ 600
AANIPWIDAD HIGIWGWSFG GYLTSKVLEK DSGAFTLGVI TAPVSDWRFY 650
DSMYTERYMK TLSTNEEGYE TSAVRKTDGF KNVEGGFLIQ HGTGDDNVHF 700
QNSAALVDLL MGDGVSPEKL HSQWFTDSDH GISYHGGGVF LYKQLARKLY 750
QEKNRQTQVL MHQWTKKDLE E 771
Length:771
Mass (Da):86,875
Last modified:January 24, 2006 - v1
Checksum:i25A9C096B0258A7B
GO

Sequence cautioni

The sequence CAA05343.1 differs from that shown. Reason: Frameshift at positions 63 and 87.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002369 Genomic DNA. Translation: CAA05343.1. Frameshift.
AP007157 Genomic DNA. Translation: BAE59130.1.
RefSeqiXP_001821132.1. XM_001821080.2.

Genome annotation databases

EnsemblFungiiCADAORAT00007710; CADAORAP00007556; CADAORAG00007710.
GeneIDi5993134.
KEGGiaor:AOR_1_1034144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002369 Genomic DNA. Translation: CAA05343.1 . Frameshift.
AP007157 Genomic DNA. Translation: BAE59130.1 .
RefSeqi XP_001821132.1. XM_001821080.2.

3D structure databases

ProteinModelPortali Q2UH35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00007556.

Protein family/group databases

MEROPSi S09.008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00007710 ; CADAORAP00007556 ; CADAORAG00007710 .
GeneIDi 5993134.
KEGGi aor:AOR_1_1034144.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01278.
OMAi WAVNYTK.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the prolyl dipeptidyl peptidase gene (dppIV) from the koji mold Aspergillus oryzae."
    Doumas A., van den Broek P., Affolter M., Monod M.
    Appl. Environ. Microbiol. 64:4809-4815(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  2. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiDPP4_ASPOR
AccessioniPrimary (citable) accession number: Q2UH35
Secondary accession number(s): O42812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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