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Protein

Dipeptidyl peptidase 4

Gene

dpp4

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.1 Publication

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

pH dependencei

Optimum pH is 7.0. is active between pH 4.0 and 9.0.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei618Charge relay systemBy similarity1
Active sitei695Charge relay systemBy similarity1
Active sitei730Charge relay systemBy similarity1

GO - Molecular functioni

  • dipeptidyl-peptidase activity Source: AspGD
  • serine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  • proteolysis Source: AspGD
  • proteolysis involved in cellular protein catabolic process Source: AspGD

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERiaspor-DPPIV. DPP4N_Peptidase_S9.
MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:AO090023000602
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 3

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500006432817 – 771Dipeptidyl peptidase 4Add BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi495N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00007556.

Structurei

3D structure databases

ProteinModelPortaliQ2UH35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01278.
OMAiNEFEGYP.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
PfamiView protein in Pfam
PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UH35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYSKLLLLL VSVVQALDVP RKPHAPTGEG SKRLTFNETV VKQAITPTSR
60 70 80 90 100
SVQWLSGAED GSYVYAAEDG SLTIENIVTN ESRTLIPADK IPTGKEAFNY
110 120 130 140 150
WIHPDLSSVL WASNHTKQYR HSFFADYYVQ DVESLKSVPL MPDQEGDIQY
160 170 180 190 200
AQWSPVGNTI AFVRENDLYV WDNGTVTRIT DDGGPDMFHG VPDWIYEEEI
210 220 230 240 250
LGDRYALWFS PDGEYLAYLS FNETGVPTYT VQYYMDNQEI APAYPWELKI
260 270 280 290 300
RYPKVSQTNP TVTLSLLNIA SKEVKQAPID AFESTDLIIG EVAWLTDTHT
310 320 330 340 350
TVAAKAFNRV QDQQKVVAVD TASNKATVIS DRDGTDGWLD NLLSMKYIGP
360 370 380 390 400
IKPSDKDAYY IDISDHSGWA HLYLFPVSGG EPIPLTKGDW EVTSILSIDQ
410 420 430 440 450
ERQLVYYLST QHHSTERHLY SVSYSTFAVT PLVDDTVAAY WSASFSANSG
460 470 480 490 500
YYILTYGGPD VPYQELYTTN STKPLRTITD NAKVLEQIKD YALPNITYFE
510 520 530 540 550
LPLPSGETLN VMQRLPPGFS PDKKYPILFT PYGGPGAQEV TKRWQALNFK
560 570 580 590 600
AYVASDSELE YVTWTVDNRG TGFKGRKFRS AVTRQLGLLE AEDQIYAAQQ
610 620 630 640 650
AANIPWIDAD HIGIWGWSFG GYLTSKVLEK DSGAFTLGVI TAPVSDWRFY
660 670 680 690 700
DSMYTERYMK TLSTNEEGYE TSAVRKTDGF KNVEGGFLIQ HGTGDDNVHF
710 720 730 740 750
QNSAALVDLL MGDGVSPEKL HSQWFTDSDH GISYHGGGVF LYKQLARKLY
760 770
QEKNRQTQVL MHQWTKKDLE E
Length:771
Mass (Da):86,875
Last modified:January 24, 2006 - v1
Checksum:i25A9C096B0258A7B
GO

Sequence cautioni

The sequence CAA05343 differs from that shown. Reason: Frameshift at positions 63 and 87.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002369 Genomic DNA. Translation: CAA05343.1. Frameshift.
AP007157 Genomic DNA. Translation: BAE59130.1.
RefSeqiXP_001821132.1. XM_001821080.2.

Genome annotation databases

EnsemblFungiiBAE59130; BAE59130; AO090023000602.
GeneIDi5993134.
KEGGiaor:AOR_1_1034144.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDPP4_ASPOR
AccessioniPrimary (citable) accession number: Q2UH35
Secondary accession number(s): O42812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 24, 2006
Last modified: July 5, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families