Reviewed, UniProtKB/Swiss-Prot Q2UGZ7 (ATG1_ASPOR)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	atg1
ORF Names:	AO090023000647

Organism

Aspergillus oryzae [Complete proteome]

Taxonomic identifier

5062 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	934 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 934	934	Serine/threonine-protein kinase atg1		PRO_0000317789
Regions
	Domain	22 – 328	307	Protein kinase
	Nucleotide binding	28 – 36	9	ATP By similarity
Sites
	Active site	165	1	Proton acceptor By similarity
	Binding site	51	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2UGZ7-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: D45CD6ED9C4400F3	FASTA	934	102,377
	10 20 30 40 50 60 MSSSHHRRSR ETSHAEMPIG RYTRLDEIGR GSFATVYQGV HTKSRTYVAI KSVNLSKLNK 70 80 90 100 110 120 KLKENLSSEI HILKGLYHPH IVALIDCHET TSHIHLVMEY CALGDLSLFI KRRDTLGDHR 130 140 150 160 170 180 YTQDMIAKYP NPRGGALNEV VVRHFLKQLA SALKFLRDRN LIHRDIKPQN LLLCPSPSSY 190 200 210 220 230 240 RSGVAQVVPF KGCDESFSPA TGLESLPMLK IADFGFARSL PSTSLAETLC GSPLYMAPEI 250 260 270 280 290 300 LRYEKYDAKA DLWSVGTVLY EMVVGKPPFR ATNHVELLRK IEKGEDRIKF PEENPASEQI 310 320 330 340 350 360 KSLIRMLLKR NPVERMNFSD FFDCDTITGP IPGLIADDAP STSRRSSVAV NTSGSTSRPQ 370 380 390 400 410 420 SRTGSRTPTG MKREKDASYP GKKDDQVSYP AAHRPPTQRS DTPPASSPMR RMGSGDRATT 430 440 450 460 470 480 SKETVTTTPR RPSVVSLATA PGRQELVDRN ATAAVMERQR SRNTYAGVPQ TEKQAEKTKE 490 500 510 520 530 540 ESERAAQEIA FERDYVLVEK RAVEVNAFAD ELAHSPRIQG GFPRNAYALS RRPGTQGSST 550 560 570 580 590 600 ATATSPLATT GKAMQVASGR ARADSTHTRQ GSYERRYGQS PTSAISKALH MASGRLFGMG 610 620 630 640 650 660 FSPPMTITKG GRSPPLGYNP FPAYPAAQGS LMVVGDGART NVTLDEDAKT VQVIEECATR 670 680 690 700 710 720 SDVVYGFAEV KYKQLIPLAP SVQTDPSGRA NVPGGERDST DLTDGGLTVD AVVTLSEEAL 730 740 750 760 770 780 VLYVKALSLL AKSMDIAGAW WSRKNRGEAF GESAMGRTDA TSTLVSNRIN NVVQWVRNRF 790 800 810 820 830 840 NEVLEKAEFV RLKLIEGQKR LPPDHPSHPS NHSVGPSVGS GASTDVVVSS GVTAEKLMYD 850 860 870 880 890 900 RALEMSRAAA INELTGEELS GCEIAYVTAI RMLEAVLEEE EVSRSEPGSG TDRGDARRDG 910 920 930 DKAMLDGVRM EDRQVVIKSS IFIVTRKQSS FVLP

References

[1]

"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed: 16372010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP007157 Genomic DNA. Translation: BAE59168.1.
RefSeq	XP_001821170.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5993172.
KEGG	aor:AO090023000647.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_ASPOR

Accession

Primary (citable) accession number: Q2UGZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 24, 2006
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)