Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2UEX1 (HAT1_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase type B catalytic subunit

EC=2.3.1.48
Gene names
Name:hat1
ORF Names:AO090026000444
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAT1 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin silencing at telomere

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Histone acetyltransferase type B catalytic subunit
PRO_0000227718

Sequences

Sequence LengthMass (Da)Tools
Q2UEX1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 276138C26F25C1F4

FASTA51158,620
        10         20         30         40         50         60 
MASEGDWTCD ANDAVQITLV QPGEQKPKTL SSFHPQFTYP IFGDDETIFG YKGLIIRLRF 

        70         80         90        100        110        120 
AAHDLRPHIH ISYDEKFKTV GDTSAVDLIK TLSPFIPEEA FSTLPDYENA VQEDKDAKDF 

       130        140        150        160        170        180 
VPPGKLVHNY VTRGRTYEIW AASLADPQVR RLLDRAQVFV SLFIEAGTPL ETEDPEWTLE 

       190        200        210        220        230        240 
RWTVYFVYEK VKPPTPTASQ YSIVGYATTY RWWFYQRDSP EKGTVTNDPF PGPEIRPAQL 

       250        260        270        280        290        300 
PARLRIAQFL ILPPHQGSGH GTHLYTTIHT ACFNDSTIVE LTVEDPNEAF DALRDTADFH 

       310        320        330        340        350        360 
ILRPEFLKHN VNINPDPYAE LSKKQRPRRV PTSALIPTKL LHDIRSTYKI ASTQFAHVLE 

       370        380        390        400        410        420 
MFLLGEIPTK NRHAGGANMS RLLVKKYNAT DPNERRYYWW RMLVKQRLFK RSRDILIQLE 

       430        440        450        460        470        480 
MSDRIEKLEE TVTNVEEGYE ALIKVFTARE EALMAKQEES GESPETAVLE DSVASSSDSS 

       490        500        510 
TRDQRTKRKF TVEDEDEEEE GESEVSKRPK V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007159 Genomic DNA. Translation: BAE59894.1.
RefSeqXP_001821896.1. XM_001821844.1.

3D structure databases

ProteinModelPortalQ2UEX1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00008312.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00008481; CADAORAP00008312; CADAORAG00008481.
GeneID5993924.
KEGGaor:AOR_1_818014.

Phylogenomic databases

eggNOGNOG326277.
HOGENOMHOG000164382.
KOK11303.
OMAHISYDEK.
OrthoDBEOG7HTHSD.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERPTHR12046. PTHR12046. 1 hit.
PfamPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAT1_ASPOR
AccessionPrimary (citable) accession number: Q2UEX1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 24, 2006
Last modified: November 13, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families