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Q2UEX1

- HAT1_ASPOR

UniProt

Q2UEX1 - HAT1_ASPOR

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Protein

Histone acetyltransferase type B catalytic subunit

Gene
hat1, AO090026000444
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
Gene namesi
Name:hat1
ORF Names:AO090026000444
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 3

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Histone acetyltransferase type B catalytic subunitPRO_0000227718Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.

Protein-protein interaction databases

STRINGi5062.CADAORAP00008312.

Structurei

3D structure databases

ProteinModelPortaliQ2UEX1.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAT1 family.

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000164382.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2UEX1-1 [UniParc]FASTAAdd to Basket

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MASEGDWTCD ANDAVQITLV QPGEQKPKTL SSFHPQFTYP IFGDDETIFG    50
YKGLIIRLRF AAHDLRPHIH ISYDEKFKTV GDTSAVDLIK TLSPFIPEEA 100
FSTLPDYENA VQEDKDAKDF VPPGKLVHNY VTRGRTYEIW AASLADPQVR 150
RLLDRAQVFV SLFIEAGTPL ETEDPEWTLE RWTVYFVYEK VKPPTPTASQ 200
YSIVGYATTY RWWFYQRDSP EKGTVTNDPF PGPEIRPAQL PARLRIAQFL 250
ILPPHQGSGH GTHLYTTIHT ACFNDSTIVE LTVEDPNEAF DALRDTADFH 300
ILRPEFLKHN VNINPDPYAE LSKKQRPRRV PTSALIPTKL LHDIRSTYKI 350
ASTQFAHVLE MFLLGEIPTK NRHAGGANMS RLLVKKYNAT DPNERRYYWW 400
RMLVKQRLFK RSRDILIQLE MSDRIEKLEE TVTNVEEGYE ALIKVFTARE 450
EALMAKQEES GESPETAVLE DSVASSSDSS TRDQRTKRKF TVEDEDEEEE 500
GESEVSKRPK V 511
Length:511
Mass (Da):58,620
Last modified:January 24, 2006 - v1
Checksum:i276138C26F25C1F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007159 Genomic DNA. Translation: BAE59894.1.
RefSeqiXP_001821896.1. XM_001821844.1.

Genome annotation databases

EnsemblFungiiCADAORAT00008481; CADAORAP00008312; CADAORAG00008481.
GeneIDi5993924.
KEGGiaor:AOR_1_818014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007159 Genomic DNA. Translation: BAE59894.1 .
RefSeqi XP_001821896.1. XM_001821844.1.

3D structure databases

ProteinModelPortali Q2UEX1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00008312.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00008481 ; CADAORAP00008312 ; CADAORAG00008481 .
GeneIDi 5993924.
KEGGi aor:AOR_1_818014.

Phylogenomic databases

eggNOGi NOG326277.
HOGENOMi HOG000164382.
KOi K11303.
OMAi HISYDEK.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiHAT1_ASPOR
AccessioniPrimary (citable) accession number: Q2UEX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 24, 2006
Last modified: November 13, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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