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Q2UEX1

- HAT1_ASPOR

UniProt

Q2UEX1 - HAT1_ASPOR

Protein

Histone acetyltransferase type B catalytic subunit

Gene

hat1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chromatin silencing at telomere Source: InterPro
    2. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
    Gene namesi
    Name:hat1
    ORF Names:AO090026000444
    OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
    Taxonomic identifieri510516 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006564: Chromosome 3

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Histone acetyltransferase type B catalytic subunitPRO_0000227718Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.By similarity

    Protein-protein interaction databases

    STRINGi5062.CADAORAP00008312.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2UEX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAT1 family.Curated

    Phylogenomic databases

    eggNOGiNOG326277.
    HOGENOMiHOG000164382.
    KOiK11303.
    OMAiHISYDEK.
    OrthoDBiEOG7HTHSD.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    [Graphical view]
    PANTHERiPTHR12046. PTHR12046. 1 hit.
    PfamiPF10394. Hat1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2UEX1-1 [UniParc]FASTAAdd to Basket

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    MASEGDWTCD ANDAVQITLV QPGEQKPKTL SSFHPQFTYP IFGDDETIFG    50
    YKGLIIRLRF AAHDLRPHIH ISYDEKFKTV GDTSAVDLIK TLSPFIPEEA 100
    FSTLPDYENA VQEDKDAKDF VPPGKLVHNY VTRGRTYEIW AASLADPQVR 150
    RLLDRAQVFV SLFIEAGTPL ETEDPEWTLE RWTVYFVYEK VKPPTPTASQ 200
    YSIVGYATTY RWWFYQRDSP EKGTVTNDPF PGPEIRPAQL PARLRIAQFL 250
    ILPPHQGSGH GTHLYTTIHT ACFNDSTIVE LTVEDPNEAF DALRDTADFH 300
    ILRPEFLKHN VNINPDPYAE LSKKQRPRRV PTSALIPTKL LHDIRSTYKI 350
    ASTQFAHVLE MFLLGEIPTK NRHAGGANMS RLLVKKYNAT DPNERRYYWW 400
    RMLVKQRLFK RSRDILIQLE MSDRIEKLEE TVTNVEEGYE ALIKVFTARE 450
    EALMAKQEES GESPETAVLE DSVASSSDSS TRDQRTKRKF TVEDEDEEEE 500
    GESEVSKRPK V 511
    Length:511
    Mass (Da):58,620
    Last modified:January 24, 2006 - v1
    Checksum:i276138C26F25C1F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007159 Genomic DNA. Translation: BAE59894.1.
    RefSeqiXP_001821896.1. XM_001821844.1.

    Genome annotation databases

    EnsemblFungiiCADAORAT00008481; CADAORAP00008312; CADAORAG00008481.
    GeneIDi5993924.
    KEGGiaor:AOR_1_818014.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007159 Genomic DNA. Translation: BAE59894.1 .
    RefSeqi XP_001821896.1. XM_001821844.1.

    3D structure databases

    ProteinModelPortali Q2UEX1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5062.CADAORAP00008312.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAORAT00008481 ; CADAORAP00008312 ; CADAORAG00008481 .
    GeneIDi 5993924.
    KEGGi aor:AOR_1_818014.

    Phylogenomic databases

    eggNOGi NOG326277.
    HOGENOMi HOG000164382.
    KOi K11303.
    OMAi HISYDEK.
    OrthoDBi EOG7HTHSD.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    [Graphical view ]
    PANTHERi PTHR12046. PTHR12046. 1 hit.
    Pfami PF10394. Hat1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of Aspergillus oryzae."
      Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
      , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
      Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42149 / RIB 40.

    Entry informationi

    Entry nameiHAT1_ASPOR
    AccessioniPrimary (citable) accession number: Q2UEX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3