Reviewed, UniProtKB/Swiss-Prot Q2UEX1 (HAT1_ASPOR)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase type B catalytic subunit
    EC=2.3.1.48

Gene names

Name:	hat1
ORF Names:	AO090026000444

Organism

Aspergillus oryzae [Complete proteome]

Taxonomic identifier

5062 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subunit structure	Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the HAT1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin silencing at telomere Inferred from electronic annotation. Source: InterPro histone acetylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Histone acetyltransferase type B catalytic subunit		PRO_0000227718

Sequences

	Sequence		Length	Mass (Da)
	Q2UEX1-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 276138C26F25C1F4	FASTA	511	58,620
	10 20 30 40 50 60 MASEGDWTCD ANDAVQITLV QPGEQKPKTL SSFHPQFTYP IFGDDETIFG YKGLIIRLRF 70 80 90 100 110 120 AAHDLRPHIH ISYDEKFKTV GDTSAVDLIK TLSPFIPEEA FSTLPDYENA VQEDKDAKDF 130 140 150 160 170 180 VPPGKLVHNY VTRGRTYEIW AASLADPQVR RLLDRAQVFV SLFIEAGTPL ETEDPEWTLE 190 200 210 220 230 240 RWTVYFVYEK VKPPTPTASQ YSIVGYATTY RWWFYQRDSP EKGTVTNDPF PGPEIRPAQL 250 260 270 280 290 300 PARLRIAQFL ILPPHQGSGH GTHLYTTIHT ACFNDSTIVE LTVEDPNEAF DALRDTADFH 310 320 330 340 350 360 ILRPEFLKHN VNINPDPYAE LSKKQRPRRV PTSALIPTKL LHDIRSTYKI ASTQFAHVLE 370 380 390 400 410 420 MFLLGEIPTK NRHAGGANMS RLLVKKYNAT DPNERRYYWW RMLVKQRLFK RSRDILIQLE 430 440 450 460 470 480 MSDRIEKLEE TVTNVEEGYE ALIKVFTARE EALMAKQEES GESPETAVLE DSVASSSDSS 490 500 510 TRDQRTKRKF TVEDEDEEEE GESEVSKRPK V

References

[1]

"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed: 16372010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP007159 Genomic DNA. Translation: BAE59894.1.
RefSeq	XP_001821896.1.
3D structure databases
SMR	Q2UEX1. Positions 3-365.
ModBase	Search...
Genome annotation databases
GeneID	5993924.
GenomeReviews	Gene locus hat1 in contig AP007159_GR.
KEGG	aor:AO090026000444.
Phylogenomic databases
OrthoDB	EOG9CG1RQ.
PhylomeDB	Q2UEX1.
Enzyme and pathway databases
BRENDA	2.3.1.48. 2240.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF10394. Hat1_N. 1 hit. [Graphical view]
PIRSF	PIRSF038084. HAT-B_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HAT1_ASPOR

Accession

Primary (citable) accession number: Q2UEX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	January 24, 2006
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)