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Protein

Probable beta-glucosidase M

Gene

bglM

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase M (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase M
Cellobiase M
Gentiobiase M
Gene namesi
Name:bglM
ORF Names:AO090012000135
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564 Componenti: Chromosome 4

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 768749Probable beta-glucosidase MPRO_0000394907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00005648.

Structurei

3D structure databases

ProteinModelPortaliQ2UDK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiAWASAYE.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2UDK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHAIAGLTGL LAGVSLSYAA PTHENITSDA YFYGQSPAVY PSPEGTGSGA
60 70 80 90 100
WASAYEKAKA FVANLTPEEK VNLTAGTDAD NGCSGNIPAI PRLNFPGLCV
110 120 130 140 150
SDAGNGLRST DHVNAWSSGI HTGASWNKDL AQKRGLHMGS EYHKKGVNVL
160 170 180 190 200
LGPVVGPLGR IAEGGRNWEG FSVDPYHSGL LVYETIRGIQ AAGVGTSTKH
210 220 230 240 250
YIANEQETNR NPESTDGIDV AAVSSNIDDK TMHELYLWPF QDVVRAGSVS
260 270 280 290 300
IMCSYQRINN SYGCQNSKTL NGLLKTELGF QGYVMTDWGA QHGGIASSNA
310 320 330 340 350
GLDMVMPSST LWNSNLTDAI ANGTMEASRL DDMATRIIAS WYQMNQDAGF
360 370 380 390 400
PSPGVGMPAD VYAPHQAIIG KSSDSRKVLL QSAIEGHVLV KNKNNTLPLK
410 420 430 440 450
SPEMISVFGY DAKGPDSLGF ALEWLSYSPA IQPNHTLIVG GGSGGNSPAY
460 470 480 490 500
ISAPLDALQQ QVIEDGSSIL WNISAQDPEV DPNTDACLVF INSYATEGYD
510 520 530 540 550
RAGLVDEGSD ELVTNVASKC SNTIVTIHNA GIRLVNNWID HENVTAVIFA
560 570 580 590 600
HLPGQDSGRA LVELLYGRSN PSGKLPYTVA KSADDYGALL HPKLPEGQYG
610 620 630 640 650
LFPQDDFSEG VYIDYRAFDK QGIEPQFEFG FGLSYTTFDY SGLNIGQVSD
660 670 680 690 700
NSTSRYPPSA AIQEGGNPHL WDVILRVSVD ITNSGPVAGD EVAQLYVGIP
710 720 730 740 750
NGPVRQLRGF EKVNIPVGQT VTVEFALGRR DLSTWDVVAQ EWLLQSGTYQ
760
VYVGRSSRDL PLQGEFTI
Length:768
Mass (Da):82,363
Last modified:January 24, 2006 - v1
Checksum:iC0177EC254F455ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007161 Genomic DNA. Translation: BAE60358.1.
RefSeqiXP_001727197.1. XM_001727145.1.

Genome annotation databases

EnsemblFungiiCADAORAT00005751; CADAORAP00005648; CADAORAG00005751.
GeneIDi5987671.
KEGGiaor:AOR_1_230194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007161 Genomic DNA. Translation: BAE60358.1.
RefSeqiXP_001727197.1. XM_001727145.1.

3D structure databases

ProteinModelPortaliQ2UDK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5062.CADAORAP00005648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00005751; CADAORAP00005648; CADAORAG00005751.
GeneIDi5987671.
KEGGiaor:AOR_1_230194.

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiAWASAYE.
OrthoDBiEOG7HMS8F.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiBGLM_ASPOR
AccessioniPrimary (citable) accession number: Q2UDK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 24, 2006
Last modified: April 1, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.