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Q2UDH2

- NTE1_ASPOR

UniProt

Q2UDH2 - NTE1_ASPOR

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1268 – 12681By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi692 – 811120cNMP 1Add
    BLAST
    Nucleotide bindingi856 – 976121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase nte1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:AO090012000173
    OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
    Taxonomic identifieri510516 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006564: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15381538Lysophospholipase nte1PRO_0000295312Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5062.CADAORAP00005683.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2UDH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7474CytoplasmicBy similarityAdd
    BLAST
    Topological domaini96 – 11722LumenalBy similarityAdd
    BLAST
    Topological domaini139 – 15381400CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1235 – 1399165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1266 – 12705GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi11 – 5747Ser-richAdd
    BLAST
    Compositional biasi60 – 6910Poly-Pro
    Compositional biasi304 – 3107Poly-Ser

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2UDH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATDGGPLAA SSASLDSSLS PLHASPSPSS TYTASSLALS APAIAASFSV     50
    ASTFSNSLIP PPPLPPPTPS TMAGWFGWVF SFFFQVIPSV LYWVITFATI 100
    TLPTWLFTLF SMSLTFTMNF TTLLLIALAI VSTISWFIRY RFLNMYSRLP 150
    SEPQRKEPHL DLFPDVQEGD SKPGLANYLD EFLSAIKVFG YLERPVFHEL 200
    TRTMQTRKLI AGETLMLEEE KGFCLVVDGL VQIFVKSMRD GKPNVDEGSN 250
    HMGAESSDED DHRVDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRA 300
    SEGSSSSASS VGPSTNARVS DSFPASPHGL EDSPRSNFVR DHGDSVAHIS 350
    NSNGELLPSV PPLNLGESHA MPIQEPYPKP RSQPGKRRRK SVHPDIVARA 400
    MVDTTIAIIP ASAFRRLTRV YPRATAHIVQ VILTRLQRVT FATAHSYLGL 450
    NNDVLGIEKQ MTKFTTQDLP NEMRGAALDR LKDKFIKERD RLGPEEIIKG 500
    IALHNPFAGR RRRSSSFLRK EAVLHAKMAA QSKRPVSMAS PEDISGDRES 550
    AGPSPGDLLS TIQLSRFGPR YEHLAPKLLS PLTDKENPPF MAPVMHSSPF 600
    HRKKDAVDED ALFRESILDC IMNGIGLTSS TRDVLRKSSH TSGDISPKLL 650
    SYDSRRQKAV FTNNAFGFID PYDSSADGET ESMMSMSMTS AGGTSPIVNL 700
    REELRNDIEI VYFPQGSVLV EQGERHPGLY YVIDGFLDVG IPVSDKGEDL 750
    VGGSRPVYGQ PPEEFFPTLK RTTTSSSRVS GVTSATNDTK RKRQSRKSLY 800
    LIKPGGIQGY VGSVASYRSY TDVVAKTDVY VGFLPRSSLE RIAERYPIAL 850
    LTLAKRLTSL LPRLLLHIDF ALEWVQVSAG QVIYHQGDES DAIYLVLNGR 900
    LRSVLEGTDG KITVVGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF 950
    PRSLFNSLAQ EHPGITIQVS KLIAQRMRDL VELPMPEKGG EHANVGSVKT 1000
    AASVVNLRTV GILPVTAGVP VVEFGHRLQN ALHQIGVTNG VTSLNQAAIL 1050
    NHLGRHAFSK MGKLKLSQYL ADLEEKYGMV LYIADTNVNS PWTQTCITQA 1100
    DCILLVGLAE SSPSIGEYER FLLGMKTTAR KELVLLHSER YCPPGLTRQW 1150
    LKNRMWINGG HHHIQMGFRL TPEPSHPQAK RLGAVLKQRV QVIQAEIQKY 1200
    TSRRIRQTPL YSAQTPFKGD FHRLARRLCG RSVGLVLGGG GARGIAQVGV 1250
    IKALEEAGIP IDIIGGTSIG SFIGALYARD ADVVPMYGRA KKFAGRMASM 1300
    WRFMLDLTYP TTSYTTGHEF NRGIFKTFGD SQIEDFWLEY YCNTTNISKS 1350
    RPEFHSSGYT WRYVRASMSL AGLIPPICDE GSMLLDGGYI DNLTVTHMKG 1400
    LGADVIFAVD VGSIDDNTPQ GYGDSLSGFW TVLNRWNPFS ACPNPPTLSE 1450
    IQARLAYVSS IDNLERAKNT PGCLYMRPPI DPYGTLEFGK FDEIYQVGYA 1500
    YGKQYLEKLR SEGSLPLPEE TEEKKKLQRT LAPRRASI 1538
    Length:1,538
    Mass (Da):169,603
    Last modified:July 24, 2007 - v2
    Checksum:iF4CE23D63EA35DD7
    GO

    Sequence cautioni

    The sequence BAE60393.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007161 Genomic DNA. Translation: BAE60393.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007161 Genomic DNA. Translation: BAE60393.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q2UDH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5062.CADAORAP00005683.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of Aspergillus oryzae."
      Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
      , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
      Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42149 / RIB 40.

    Entry informationi

    Entry nameiNTE1_ASPOR
    AccessioniPrimary (citable) accession number: Q2UDH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3