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Q2UDH2

- NTE1_ASPOR

UniProt

Q2UDH2 - NTE1_ASPOR

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Protein
Lysophospholipase nte1
Gene
nte1, AO090012000173
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1268 – 12681 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi692 – 811120cNMP 1
Add
BLAST
Nucleotide bindingi856 – 976121cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AO090012000173
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474Cytoplasmic By similarity
Add
BLAST
Transmembranei75 – 9521Helical; Reviewed prediction
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BLAST
Topological domaini96 – 11722Lumenal By similarity
Add
BLAST
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Topological domaini139 – 15381400Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15381538Lysophospholipase nte1
PRO_0000295312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00005683.

Structurei

3D structure databases

ProteinModelPortaliQ2UDH2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1235 – 1399165Patatin
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BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1266 – 12705GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 5747Ser-rich
Add
BLAST
Compositional biasi60 – 6910Poly-Pro
Compositional biasi304 – 3107Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UDH2-1 [UniParc]FASTAAdd to Basket

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MATDGGPLAA SSASLDSSLS PLHASPSPSS TYTASSLALS APAIAASFSV     50
ASTFSNSLIP PPPLPPPTPS TMAGWFGWVF SFFFQVIPSV LYWVITFATI 100
TLPTWLFTLF SMSLTFTMNF TTLLLIALAI VSTISWFIRY RFLNMYSRLP 150
SEPQRKEPHL DLFPDVQEGD SKPGLANYLD EFLSAIKVFG YLERPVFHEL 200
TRTMQTRKLI AGETLMLEEE KGFCLVVDGL VQIFVKSMRD GKPNVDEGSN 250
HMGAESSDED DHRVDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRA 300
SEGSSSSASS VGPSTNARVS DSFPASPHGL EDSPRSNFVR DHGDSVAHIS 350
NSNGELLPSV PPLNLGESHA MPIQEPYPKP RSQPGKRRRK SVHPDIVARA 400
MVDTTIAIIP ASAFRRLTRV YPRATAHIVQ VILTRLQRVT FATAHSYLGL 450
NNDVLGIEKQ MTKFTTQDLP NEMRGAALDR LKDKFIKERD RLGPEEIIKG 500
IALHNPFAGR RRRSSSFLRK EAVLHAKMAA QSKRPVSMAS PEDISGDRES 550
AGPSPGDLLS TIQLSRFGPR YEHLAPKLLS PLTDKENPPF MAPVMHSSPF 600
HRKKDAVDED ALFRESILDC IMNGIGLTSS TRDVLRKSSH TSGDISPKLL 650
SYDSRRQKAV FTNNAFGFID PYDSSADGET ESMMSMSMTS AGGTSPIVNL 700
REELRNDIEI VYFPQGSVLV EQGERHPGLY YVIDGFLDVG IPVSDKGEDL 750
VGGSRPVYGQ PPEEFFPTLK RTTTSSSRVS GVTSATNDTK RKRQSRKSLY 800
LIKPGGIQGY VGSVASYRSY TDVVAKTDVY VGFLPRSSLE RIAERYPIAL 850
LTLAKRLTSL LPRLLLHIDF ALEWVQVSAG QVIYHQGDES DAIYLVLNGR 900
LRSVLEGTDG KITVVGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF 950
PRSLFNSLAQ EHPGITIQVS KLIAQRMRDL VELPMPEKGG EHANVGSVKT 1000
AASVVNLRTV GILPVTAGVP VVEFGHRLQN ALHQIGVTNG VTSLNQAAIL 1050
NHLGRHAFSK MGKLKLSQYL ADLEEKYGMV LYIADTNVNS PWTQTCITQA 1100
DCILLVGLAE SSPSIGEYER FLLGMKTTAR KELVLLHSER YCPPGLTRQW 1150
LKNRMWINGG HHHIQMGFRL TPEPSHPQAK RLGAVLKQRV QVIQAEIQKY 1200
TSRRIRQTPL YSAQTPFKGD FHRLARRLCG RSVGLVLGGG GARGIAQVGV 1250
IKALEEAGIP IDIIGGTSIG SFIGALYARD ADVVPMYGRA KKFAGRMASM 1300
WRFMLDLTYP TTSYTTGHEF NRGIFKTFGD SQIEDFWLEY YCNTTNISKS 1350
RPEFHSSGYT WRYVRASMSL AGLIPPICDE GSMLLDGGYI DNLTVTHMKG 1400
LGADVIFAVD VGSIDDNTPQ GYGDSLSGFW TVLNRWNPFS ACPNPPTLSE 1450
IQARLAYVSS IDNLERAKNT PGCLYMRPPI DPYGTLEFGK FDEIYQVGYA 1500
YGKQYLEKLR SEGSLPLPEE TEEKKKLQRT LAPRRASI 1538
Length:1,538
Mass (Da):169,603
Last modified:July 24, 2007 - v2
Checksum:iF4CE23D63EA35DD7
GO

Sequence cautioni

The sequence BAE60393.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007161 Genomic DNA. Translation: BAE60393.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007161 Genomic DNA. Translation: BAE60393.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q2UDH2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00005683.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiNTE1_ASPOR
AccessioniPrimary (citable) accession number: Q2UDH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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