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Q2UDH2 (NTE1_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase nte1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:AO090012000173
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1538 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence BAE60393.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15381538Lysophospholipase nte1
PRO_0000295312

Regions

Topological domain1 – 7474Cytoplasmic By similarity
Transmembrane75 – 9521Helical; Potential
Topological domain96 – 11722Lumenal By similarity
Transmembrane118 – 13821Helical; Potential
Topological domain139 – 15381400Cytoplasmic By similarity
Domain1235 – 1399165Patatin
Nucleotide binding692 – 811120cNMP 1
Nucleotide binding856 – 976121cNMP 2
Motif1266 – 12705GXSXG
Compositional bias11 – 5747Ser-rich
Compositional bias60 – 6910Poly-Pro
Compositional bias304 – 3107Poly-Ser

Sites

Active site12681 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2UDH2 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: F4CE23D63EA35DD7

FASTA1,538169,603
        10         20         30         40         50         60 
MATDGGPLAA SSASLDSSLS PLHASPSPSS TYTASSLALS APAIAASFSV ASTFSNSLIP 

        70         80         90        100        110        120 
PPPLPPPTPS TMAGWFGWVF SFFFQVIPSV LYWVITFATI TLPTWLFTLF SMSLTFTMNF 

       130        140        150        160        170        180 
TTLLLIALAI VSTISWFIRY RFLNMYSRLP SEPQRKEPHL DLFPDVQEGD SKPGLANYLD 

       190        200        210        220        230        240 
EFLSAIKVFG YLERPVFHEL TRTMQTRKLI AGETLMLEEE KGFCLVVDGL VQIFVKSMRD 

       250        260        270        280        290        300 
GKPNVDEGSN HMGAESSDED DHRVDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRA 

       310        320        330        340        350        360 
SEGSSSSASS VGPSTNARVS DSFPASPHGL EDSPRSNFVR DHGDSVAHIS NSNGELLPSV 

       370        380        390        400        410        420 
PPLNLGESHA MPIQEPYPKP RSQPGKRRRK SVHPDIVARA MVDTTIAIIP ASAFRRLTRV 

       430        440        450        460        470        480 
YPRATAHIVQ VILTRLQRVT FATAHSYLGL NNDVLGIEKQ MTKFTTQDLP NEMRGAALDR 

       490        500        510        520        530        540 
LKDKFIKERD RLGPEEIIKG IALHNPFAGR RRRSSSFLRK EAVLHAKMAA QSKRPVSMAS 

       550        560        570        580        590        600 
PEDISGDRES AGPSPGDLLS TIQLSRFGPR YEHLAPKLLS PLTDKENPPF MAPVMHSSPF 

       610        620        630        640        650        660 
HRKKDAVDED ALFRESILDC IMNGIGLTSS TRDVLRKSSH TSGDISPKLL SYDSRRQKAV 

       670        680        690        700        710        720 
FTNNAFGFID PYDSSADGET ESMMSMSMTS AGGTSPIVNL REELRNDIEI VYFPQGSVLV 

       730        740        750        760        770        780 
EQGERHPGLY YVIDGFLDVG IPVSDKGEDL VGGSRPVYGQ PPEEFFPTLK RTTTSSSRVS 

       790        800        810        820        830        840 
GVTSATNDTK RKRQSRKSLY LIKPGGIQGY VGSVASYRSY TDVVAKTDVY VGFLPRSSLE 

       850        860        870        880        890        900 
RIAERYPIAL LTLAKRLTSL LPRLLLHIDF ALEWVQVSAG QVIYHQGDES DAIYLVLNGR 

       910        920        930        940        950        960 
LRSVLEGTDG KITVVGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ 

       970        980        990       1000       1010       1020 
EHPGITIQVS KLIAQRMRDL VELPMPEKGG EHANVGSVKT AASVVNLRTV GILPVTAGVP 

      1030       1040       1050       1060       1070       1080 
VVEFGHRLQN ALHQIGVTNG VTSLNQAAIL NHLGRHAFSK MGKLKLSQYL ADLEEKYGMV 

      1090       1100       1110       1120       1130       1140 
LYIADTNVNS PWTQTCITQA DCILLVGLAE SSPSIGEYER FLLGMKTTAR KELVLLHSER 

      1150       1160       1170       1180       1190       1200 
YCPPGLTRQW LKNRMWINGG HHHIQMGFRL TPEPSHPQAK RLGAVLKQRV QVIQAEIQKY 

      1210       1220       1230       1240       1250       1260 
TSRRIRQTPL YSAQTPFKGD FHRLARRLCG RSVGLVLGGG GARGIAQVGV IKALEEAGIP 

      1270       1280       1290       1300       1310       1320 
IDIIGGTSIG SFIGALYARD ADVVPMYGRA KKFAGRMASM WRFMLDLTYP TTSYTTGHEF 

      1330       1340       1350       1360       1370       1380 
NRGIFKTFGD SQIEDFWLEY YCNTTNISKS RPEFHSSGYT WRYVRASMSL AGLIPPICDE 

      1390       1400       1410       1420       1430       1440 
GSMLLDGGYI DNLTVTHMKG LGADVIFAVD VGSIDDNTPQ GYGDSLSGFW TVLNRWNPFS 

      1450       1460       1470       1480       1490       1500 
ACPNPPTLSE IQARLAYVSS IDNLERAKNT PGCLYMRPPI DPYGTLEFGK FDEIYQVGYA 

      1510       1520       1530 
YGKQYLEKLR SEGSLPLPEE TEEKKKLQRT LAPRRASI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007161 Genomic DNA. Translation: BAE60393.1. Sequence problems.

3D structure databases

ProteinModelPortalQ2UDH2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00005683.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_ASPOR
AccessionPrimary (citable) accession number: Q2UDH2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families