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Q2UDH2

- NTE1_ASPOR

UniProt

Q2UDH2 - NTE1_ASPOR

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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1268 – 12681By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi692 – 811120cNMP 1Add
BLAST
Nucleotide bindingi856 – 976121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AO090012000173
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15381538Lysophospholipase nte1PRO_0000295312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00005683.

Structurei

3D structure databases

ProteinModelPortaliQ2UDH2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicBy similarityAdd
BLAST
Topological domaini96 – 11722LumenalBy similarityAdd
BLAST
Topological domaini139 – 15381400CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1235 – 1399165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1266 – 12705GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 5747Ser-richAdd
BLAST
Compositional biasi60 – 6910Poly-Pro
Compositional biasi304 – 3107Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UDH2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATDGGPLAA SSASLDSSLS PLHASPSPSS TYTASSLALS APAIAASFSV
60 70 80 90 100
ASTFSNSLIP PPPLPPPTPS TMAGWFGWVF SFFFQVIPSV LYWVITFATI
110 120 130 140 150
TLPTWLFTLF SMSLTFTMNF TTLLLIALAI VSTISWFIRY RFLNMYSRLP
160 170 180 190 200
SEPQRKEPHL DLFPDVQEGD SKPGLANYLD EFLSAIKVFG YLERPVFHEL
210 220 230 240 250
TRTMQTRKLI AGETLMLEEE KGFCLVVDGL VQIFVKSMRD GKPNVDEGSN
260 270 280 290 300
HMGAESSDED DHRVDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRA
310 320 330 340 350
SEGSSSSASS VGPSTNARVS DSFPASPHGL EDSPRSNFVR DHGDSVAHIS
360 370 380 390 400
NSNGELLPSV PPLNLGESHA MPIQEPYPKP RSQPGKRRRK SVHPDIVARA
410 420 430 440 450
MVDTTIAIIP ASAFRRLTRV YPRATAHIVQ VILTRLQRVT FATAHSYLGL
460 470 480 490 500
NNDVLGIEKQ MTKFTTQDLP NEMRGAALDR LKDKFIKERD RLGPEEIIKG
510 520 530 540 550
IALHNPFAGR RRRSSSFLRK EAVLHAKMAA QSKRPVSMAS PEDISGDRES
560 570 580 590 600
AGPSPGDLLS TIQLSRFGPR YEHLAPKLLS PLTDKENPPF MAPVMHSSPF
610 620 630 640 650
HRKKDAVDED ALFRESILDC IMNGIGLTSS TRDVLRKSSH TSGDISPKLL
660 670 680 690 700
SYDSRRQKAV FTNNAFGFID PYDSSADGET ESMMSMSMTS AGGTSPIVNL
710 720 730 740 750
REELRNDIEI VYFPQGSVLV EQGERHPGLY YVIDGFLDVG IPVSDKGEDL
760 770 780 790 800
VGGSRPVYGQ PPEEFFPTLK RTTTSSSRVS GVTSATNDTK RKRQSRKSLY
810 820 830 840 850
LIKPGGIQGY VGSVASYRSY TDVVAKTDVY VGFLPRSSLE RIAERYPIAL
860 870 880 890 900
LTLAKRLTSL LPRLLLHIDF ALEWVQVSAG QVIYHQGDES DAIYLVLNGR
910 920 930 940 950
LRSVLEGTDG KITVVGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF
960 970 980 990 1000
PRSLFNSLAQ EHPGITIQVS KLIAQRMRDL VELPMPEKGG EHANVGSVKT
1010 1020 1030 1040 1050
AASVVNLRTV GILPVTAGVP VVEFGHRLQN ALHQIGVTNG VTSLNQAAIL
1060 1070 1080 1090 1100
NHLGRHAFSK MGKLKLSQYL ADLEEKYGMV LYIADTNVNS PWTQTCITQA
1110 1120 1130 1140 1150
DCILLVGLAE SSPSIGEYER FLLGMKTTAR KELVLLHSER YCPPGLTRQW
1160 1170 1180 1190 1200
LKNRMWINGG HHHIQMGFRL TPEPSHPQAK RLGAVLKQRV QVIQAEIQKY
1210 1220 1230 1240 1250
TSRRIRQTPL YSAQTPFKGD FHRLARRLCG RSVGLVLGGG GARGIAQVGV
1260 1270 1280 1290 1300
IKALEEAGIP IDIIGGTSIG SFIGALYARD ADVVPMYGRA KKFAGRMASM
1310 1320 1330 1340 1350
WRFMLDLTYP TTSYTTGHEF NRGIFKTFGD SQIEDFWLEY YCNTTNISKS
1360 1370 1380 1390 1400
RPEFHSSGYT WRYVRASMSL AGLIPPICDE GSMLLDGGYI DNLTVTHMKG
1410 1420 1430 1440 1450
LGADVIFAVD VGSIDDNTPQ GYGDSLSGFW TVLNRWNPFS ACPNPPTLSE
1460 1470 1480 1490 1500
IQARLAYVSS IDNLERAKNT PGCLYMRPPI DPYGTLEFGK FDEIYQVGYA
1510 1520 1530
YGKQYLEKLR SEGSLPLPEE TEEKKKLQRT LAPRRASI
Length:1,538
Mass (Da):169,603
Last modified:July 24, 2007 - v2
Checksum:iF4CE23D63EA35DD7
GO

Sequence cautioni

The sequence BAE60393.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007161 Genomic DNA. Translation: BAE60393.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007161 Genomic DNA. Translation: BAE60393.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q2UDH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00005683.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiNTE1_ASPOR
AccessioniPrimary (citable) accession number: Q2UDH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3