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Protein

Serine/threonine-protein phosphatase 2A activator 2

Gene

rrd2

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg2+ by dissociating the inactive form from the complex (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase PTPA-2
Short name:
PPIase PTPA-2
Short name:
Rotamase PTPA-2
Phosphotyrosyl phosphatase activator 2
Gene namesi
Name:rrd2
ORF Names:AO090012000537
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:AO090012000537.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Serine/threonine-protein phosphatase 2A activator 2PRO_0000226108Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2UCL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPA-type PPIase family.Curated

Phylogenomic databases

HOGENOMiHOG000205736.
KOiK17605.
OMAiPAVEMAN.
OrthoDBiEOG76HQD0.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2UCL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEVSASQG VPKPKIDLSK KLSELRSNRK SQPALPSRPS REPAPVTPPL
60 70 80 90 100
SNPPDLSSHQ YARPVCRILS NHDHQLFLSS SSYSLILAFI FGLSDSVRGR
110 120 130 140 150
ATTDSKDRPV SPNVSKILAV VESIRTLLDQ HPSIDQGGSR FGNPAFRDLF
160 170 180 190 200
DDVAAQSAKW HREILGIQDS TAIEEASAYL IHSLGSRDRL DYGSGHELNF
210 220 230 240 250
MMWLLCLRQM QLYSTADFEM IVFRVYVTYM HLMRDVQSAY YLEPAGSHGV
260 270 280 290 300
WGLDDYHFLP FLFGAAQLVE HPYITPLAIH NNVILDEEGD RYIYLDQVRW
310 320 330 340 350
VDSVKTVKGL RWHSPMLDDI SGAKNWSKIE SGMKKMFVKE VLGKLPIMQH
360 370 380 390 400
FLFGSLIPAA PGMGEADDVQ TDGHDHTHSH DHAHAQHTDH FGDCCGIKVP
410 420
STVAAGAEAR KRGTGLRPIP FD
Length:422
Mass (Da):47,062
Last modified:January 24, 2006 - v1
Checksum:i3507713BE0D9728B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007161 Genomic DNA. Translation: BAE60699.1.
RefSeqiXP_001727538.1. XM_001727486.1.

Genome annotation databases

EnsemblFungiiCADAORAT00006104; CADAORAP00005989; CADAORAG00006104.
GeneIDi5988012.
KEGGiaor:AOR_1_944194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007161 Genomic DNA. Translation: BAE60699.1.
RefSeqiXP_001727538.1. XM_001727486.1.

3D structure databases

ProteinModelPortaliQ2UCL6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00006104; CADAORAP00005989; CADAORAG00006104.
GeneIDi5988012.
KEGGiaor:AOR_1_944194.

Organism-specific databases

EuPathDBiFungiDB:AO090012000537.

Phylogenomic databases

HOGENOMiHOG000205736.
KOiK17605.
OMAiPAVEMAN.
OrthoDBiEOG76HQD0.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiPTPA2_ASPOR
AccessioniPrimary (citable) accession number: Q2UCL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 24, 2006
Last modified: April 13, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.