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Protein

Serine/threonine-protein kinase SSN3

Gene

ssn3

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56ATPPROSITE-ProRule annotation1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:ssn3
Synonyms:cdk8
ORF Names:AO090012000729
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129361 – 413Serine/threonine-protein kinase SSN3Add BLAST413

Proteomic databases

PRIDEiQ2UC58

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi5062.CADAORAP00006147

Structurei

3D structure databases

ProteinModelPortaliQ2UC58
SMRiQ2UC58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 355Protein kinasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q2UC58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEHLDPRK PSGTGYTSKV RVRDKYHIVG FISSGTYGRV YKALGKNGQK
60 70 80 90 100
GEFAIKKFKP DKEGEIIQYT GLSQSAIREM ALCSELDHAN VVQLEEIILE
110 120 130 140 150
DKAIFMVFEY TEHDLLQIIH HHTQPHRHAI PAPMVRSILF QLLNGLLYLH
160 170 180 190 200
TSWVLHRDLK PANILVTSSG AIRIGDLGLA RLFYKPLNSL FSGDKVVVTI
210 220 230 240 250
WYRAPELLMG SRHYTPAVDL WAVGCIFAEL LSLRPIFKGE EAKMDSKKTV
260 270 280 290 300
PFQRNQMMKI IEIMGLPTKD IWPGIVSMPE YSQLQSLAMS RAPGHFPRSS
310 320 330 340 350
NLEGWYQSCL KNGGYATSSG AGTPGADGYD LLSRLLEYDP TKRITAQEAL
360 370 380 390 400
EHPYFKNGGP ISANCFEGFE GKYPHRRVTQ DDNDIRSGSL PGTKRSGLPD
410
DSLMGRASKR LKE
Length:413
Mass (Da):46,348
Last modified:January 15, 2008 - v2
Checksum:i6880CA68E840F737
GO

Sequence cautioni

The sequence BAE60857 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007161 Genomic DNA Translation: BAE60857.1 Sequence problems.

Genome annotation databases

EnsemblFungiiBAE60857; BAE60857; AO090012000729

Similar proteinsi

Entry informationi

Entry nameiSSN3_ASPOR
AccessioniPrimary (citable) accession number: Q2UC58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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