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Q2UC58 (SSN3_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:ssn3
Synonyms:cdk8
ORF Names:AO090012000729
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAE60857.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Serine/threonine-protein kinase SSN3
PRO_0000312936

Regions

Domain26 – 355330Protein kinase
Nucleotide binding32 – 409ATP By similarity

Sites

Active site1581Proton acceptor By similarity
Binding site561ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2UC58 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 6880CA68E840F737

FASTA41346,348
        10         20         30         40         50         60 
MLKEHLDPRK PSGTGYTSKV RVRDKYHIVG FISSGTYGRV YKALGKNGQK GEFAIKKFKP 

        70         80         90        100        110        120 
DKEGEIIQYT GLSQSAIREM ALCSELDHAN VVQLEEIILE DKAIFMVFEY TEHDLLQIIH 

       130        140        150        160        170        180 
HHTQPHRHAI PAPMVRSILF QLLNGLLYLH TSWVLHRDLK PANILVTSSG AIRIGDLGLA 

       190        200        210        220        230        240 
RLFYKPLNSL FSGDKVVVTI WYRAPELLMG SRHYTPAVDL WAVGCIFAEL LSLRPIFKGE 

       250        260        270        280        290        300 
EAKMDSKKTV PFQRNQMMKI IEIMGLPTKD IWPGIVSMPE YSQLQSLAMS RAPGHFPRSS 

       310        320        330        340        350        360 
NLEGWYQSCL KNGGYATSSG AGTPGADGYD LLSRLLEYDP TKRITAQEAL EHPYFKNGGP 

       370        380        390        400        410 
ISANCFEGFE GKYPHRRVTQ DDNDIRSGSL PGTKRSGLPD DSLMGRASKR LKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007161 Genomic DNA. Translation: BAE60857.1. Sequence problems.

3D structure databases

ProteinModelPortalQ2UC58.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00006147.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_ASPOR
AccessionPrimary (citable) accession number: Q2UC58
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families