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Protein

Serine/threonine-protein kinase SSN3

Gene

ssn3

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56ATPPROSITE-ProRule annotation1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:ssn3
Synonyms:cdk8
ORF Names:AO090012000729
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129361 – 413Serine/threonine-protein kinase SSN3Add BLAST413

Proteomic databases

PRIDEiQ2UC58.

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2UC58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 355Protein kinasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233024.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2UC58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEHLDPRK PSGTGYTSKV RVRDKYHIVG FISSGTYGRV YKALGKNGQK
60 70 80 90 100
GEFAIKKFKP DKEGEIIQYT GLSQSAIREM ALCSELDHAN VVQLEEIILE
110 120 130 140 150
DKAIFMVFEY TEHDLLQIIH HHTQPHRHAI PAPMVRSILF QLLNGLLYLH
160 170 180 190 200
TSWVLHRDLK PANILVTSSG AIRIGDLGLA RLFYKPLNSL FSGDKVVVTI
210 220 230 240 250
WYRAPELLMG SRHYTPAVDL WAVGCIFAEL LSLRPIFKGE EAKMDSKKTV
260 270 280 290 300
PFQRNQMMKI IEIMGLPTKD IWPGIVSMPE YSQLQSLAMS RAPGHFPRSS
310 320 330 340 350
NLEGWYQSCL KNGGYATSSG AGTPGADGYD LLSRLLEYDP TKRITAQEAL
360 370 380 390 400
EHPYFKNGGP ISANCFEGFE GKYPHRRVTQ DDNDIRSGSL PGTKRSGLPD
410
DSLMGRASKR LKE
Length:413
Mass (Da):46,348
Last modified:January 15, 2008 - v2
Checksum:i6880CA68E840F737
GO

Sequence cautioni

The sequence BAE60857 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007161 Genomic DNA. Translation: BAE60857.1. Sequence problems.

Genome annotation databases

EnsemblFungiiBAE60857; BAE60857; AO090012000729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007161 Genomic DNA. Translation: BAE60857.1. Sequence problems.

3D structure databases

ProteinModelPortaliQ2UC58.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2UC58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAE60857; BAE60857; AO090012000729.

Phylogenomic databases

HOGENOMiHOG000233024.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSN3_ASPOR
AccessioniPrimary (citable) accession number: Q2UC58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.