Reviewed, UniProtKB/Swiss-Prot Q2UA71 (HAT2_ASPOR)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase type B subunit 2
    EC=2.3.1.48

Gene names

Name:	hat2
ORF Names:	AO090102000516

Organism

Aspergillus oryzae [Complete proteome]

Taxonomic identifier

5062 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subunit structure	Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Molecular function	Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Histone acetyltransferase type B subunit 2		PRO_0000227734
Regions
	Repeat	136 – 176	41	WD 1
	Repeat	187 – 227	41	WD 2
	Repeat	237 – 277	41	WD 3
	Repeat	284 – 324	41	WD 4
	Repeat	328 – 368	41	WD 5
	Repeat	385 – 425	41	WD 6

Sequences

	Sequence		Length	Mass (Da)
	Q2UA71-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 7AD4493166876F66	FASTA	436	48,983
	10 20 30 40 50 60 MEPYDDGFIE EQEEQEEERT EEKVINEEYK TWKKNAPFLY DMILSTALEW PTLTTQWLPD 70 80 90 100 110 120 KQEVPDKPYS THRLLLGTHT SSDAQNYLQI AHVQLPNPSA PNPDDYDEER GEIGGYGGSS 130 140 150 160 170 180 KKAPMEIKFN IVQKIDHKGE VNKARYQPQN PNVIATMCTD GRVMIWDRSK HPSLPTGTVN 190 200 210 220 230 240 PQMELLGHTK EGFGLSWSPH TAGHLVTGSE DKTVRLWDLT TYTKGNKALK PSRTYTHHSS 250 260 270 280 290 300 IVNDVQYHPL HSSLIGTVSD DITLQILDIR EAETTRAAAS AEGQHRDAIN AIAFNPAAET 310 320 330 340 350 360 VLATGSADKS IGLWDLRNLK TKLHTLECHT DSVTSLSWHP FEESVLASAS YDRKIMFWDL 370 380 390 400 410 420 SRSGEEQTPD DAQDGPPELL FMHGGHTNRI SDFSWNLNDP WVLCSAAEDN LLQVWKVADA 430 IVGKDLEDVP TEELEA

References

[1]

"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed: 16372010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP007162 Genomic DNA. Translation: BAE61544.1.
RefSeq	XP_001822677.1.
3D structure databases
SMR	Q2UA71. Positions 19-423.
ModBase	Search...
Genome annotation databases
GeneID	5994722.
GenomeReviews	Gene locus hat2 in contig AP007162_GR.
KEGG	aor:AO090102000516.
Phylogenomic databases
OrthoDB	EOG9QVDVC.
PhylomeDB	Q2UA71.
Enzyme and pathway databases
BRENDA	2.3.1.48. 2240.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep_reg. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 6 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 6 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 5 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT2_ASPOR

Accession

Primary (citable) accession number: Q2UA71

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	January 24, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)