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Protein

Probable beta-glucosidase I

Gene

bglI

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway:icellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei225 – 2251By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase I (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase I
Cellobiase I
Gentiobiase I
Gene namesi
Name:bglI
ORF Names:AO090701000244
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 839839Probable beta-glucosidase IPRO_0000394888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2U8Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini396 – 542147PA14Add
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated
Contains 1 PA14 domain.Curated

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiSIAKGSH.
OrthoDBiEOG7H799Q.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2U8Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLDVEKTI EELSLGEKVA LTAGIDFWHT ASVPRLNIPT LRMSDGPNGV
60 70 80 90 100
RGTRFFNGVP AACFPCATAL GATWDTELLH EIGQLMGEES IAKGSHIILG
110 120 130 140 150
PTINTQRSPL GGRGFESFAE DGVLSGLLAG YISKGIQEKG VAATLKHFVC
160 170 180 190 200
NDQEHQRMAV DSIVTQRALR EIYLLPFQLA MRICRTACVM TAYNKVNGTH
210 220 230 240 250
VSQNKEIITD ILRKEWGWDG LVMSDWFGTY STSDAINAGL DLEMPGKTRW
260 270 280 290 300
RGTALAHAVS SNEVAEFVMD ERVRNVLNLV NFVDGLNIPE NAPEKALNRP
310 320 330 340 350
QDQALLRRAA AESVVLMKNE EDILPLKKEK SILVIGPNSK VAAYCGGGSA
360 370 380 390 400
SLDAYYTVTP FEGVSAQSKG EVKFSQGVYS HKDLPLLGPL LKTADGKTGF
410 420 430 440 450
SFKVYNEHPS ESNRELIEQL HLVSSSGFLM DYVNPKIKSL TYYVDMEGLF
460 470 480 490 500
TPEEDGVYDF GVTVVGTGQL FIDGELVVDN TKNQRQGSAF FGSATVEEKG
510 520 530 540 550
SKELKAGQTY KVLFQFGTAP TSDLDTRGVV VFGPGGFRFG ASRRVGQEEL
560 570 580 590 600
ISNAVKLASE AEQVVVFAGL TSEWETEGYD RDHMDLPPGS DEMISRVLDV
610 620 630 640 650
NPNAVVVIQS GTPVTMPWAN KTKALLHAWF GGNECGNGIA DVLYGDVNPS
660 670 680 690 700
GKLPITFPVR LQDNPSYVNF RSERGRVLYG EDVYVGYRYY EKVDLAPLFP
710 720 730 740 750
FGHGLSYTTF TRSDLTLTTT PEKPQYEESG EPITATVTVT NTGKVAGAEI
760 770 780 790 800
VQLWVAPPAT EVNRPVRELK GFTKVFLQPG EQKKVEIVVE KKLATSWFDE
810 820 830
MREKWASEKG EYEVLVTGTG EGVLKSSFKV EKTRYWLGL
Length:839
Mass (Da):92,142
Last modified:January 24, 2006 - v1
Checksum:i0A3230F3AC56079F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007164 Genomic DNA. Translation: BAE61980.1.
RefSeqiXP_001823113.1. XM_001823061.2.

Genome annotation databases

EnsemblFungiiCADAORAT00010596; CADAORAP00010383; CADAORAG00010596.
GeneIDi5995170.
KEGGiaor:AOR_1_450114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007164 Genomic DNA. Translation: BAE61980.1.
RefSeqiXP_001823113.1. XM_001823061.2.

3D structure databases

ProteinModelPortaliQ2U8Y5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00010596; CADAORAP00010383; CADAORAG00010596.
GeneIDi5995170.
KEGGiaor:AOR_1_450114.

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiSIAKGSH.
OrthoDBiEOG7H799Q.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiBGLI_ASPOR
AccessioniPrimary (citable) accession number: Q2U8Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 24, 2006
Last modified: July 22, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.