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Protein

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Gene

alg3

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc(2)-PP-Dol.By similarity

Catalytic activityi

Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT58. Glycosyltransferase Family 58.

Names & Taxonomyi

Protein namesi
Recommended name:
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC:2.4.1.258)
Alternative name(s):
Asparagine-linked glycosylation protein 6
Dol-P-Man-dependent alpha(1-3)-mannosyltransferase
Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
Gene namesi
Name:alg3
ORF Names:AO090120000319
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18LumenalSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 95CytoplasmicSequence analysisAdd BLAST56
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 139LumenalSequence analysisAdd BLAST23
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 181CytoplasmicSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 207LumenalSequence analysis5
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 261CytoplasmicSequence analysisAdd BLAST33
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 304LumenalSequence analysisAdd BLAST22
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 372CytoplasmicSequence analysisAdd BLAST47
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 413LumenalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003509231 – 413Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferaseAdd BLAST413

Structurei

3D structure databases

ProteinModelPortaliQ2U6A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALG3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000237555.
KOiK03845.
OMAiDWKAYMD.
OrthoDBiEOG092C26UZ.

Family and domain databases

InterProiIPR007873. Glycosyltransferase_ALG3.
[Graphical view]
PANTHERiPTHR12646. PTHR12646. 1 hit.
PfamiPF05208. ALG3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2U6A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKHFIHEL CLNPRHTKWI APLLVIGDAF LCALIIWKIP YTEIDWTTYM
60 70 80 90 100
QQIALYISGE RDYTLIKGST GPLVYPAAHV YSYMALYHLT DEGRDILFGQ
110 120 130 140 150
ILFAVLYLVT LAVVMVCYRQ SGAPPYLFPL LVLSKRLHSV FVLRLFNDGL
160 170 180 190 200
AVCAMWIAIL LFQNKKWTAG VTAWTVGVGI KMTLLLLAPA IAVVTVLSLS
210 220 230 240 250
LVPSIRLGIL ALLIQVLLAI PFLQGNPIGY VARAFELTRQ FMFKWTVNWR
260 270 280 290 300
FVGEDLFLSK QFSLALLGLH IFLLGLFVTT GWLRPSGSNV PDFLRSLLQG
310 320 330 340 350
RQRTVVLSKS FIMTVMLTSL AIGLLCARSL HYQFFAYLSW ATPCLLWRAR
360 370 380 390 400
LHPILIYAIW ALQEWAWNVY PSTNASSSVV VFSLAVQVFG VLLNSRNALS
410
DAPPRRKGKE HIQ
Length:413
Mass (Da):46,649
Last modified:January 24, 2006 - v1
Checksum:iD73845A54C5E4F76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007166 Genomic DNA. Translation: BAE62911.1.
RefSeqiXP_001824044.1. XM_001823992.2.

Genome annotation databases

EnsemblFungiiBAE62911; BAE62911; AO090120000319.
GeneIDi5996303.
KEGGiaor:AOR_1_556094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007166 Genomic DNA. Translation: BAE62911.1.
RefSeqiXP_001824044.1. XM_001823992.2.

3D structure databases

ProteinModelPortaliQ2U6A4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT58. Glycosyltransferase Family 58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAE62911; BAE62911; AO090120000319.
GeneIDi5996303.
KEGGiaor:AOR_1_556094.

Phylogenomic databases

HOGENOMiHOG000237555.
KOiK03845.
OMAiDWKAYMD.
OrthoDBiEOG092C26UZ.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR007873. Glycosyltransferase_ALG3.
[Graphical view]
PANTHERiPTHR12646. PTHR12646. 1 hit.
PfamiPF05208. ALG3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALG3_ASPOR
AccessioniPrimary (citable) accession number: Q2U6A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.