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Protein

Serine/threonine-protein kinase tel1

Gene

tel1

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase tel1 (EC:2.7.11.1)
Alternative name(s):
ATM homolog
DNA-damage checkpoint kinase tel1
Telomere length regulation protein 1
Gene namesi
Name:tel1
ORF Names:AO090120000393
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 5

Subcellular locationi

  • Nucleus By similarity
  • Chromosometelomere By similarity

  • Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002276971 – 2925Serine/threonine-protein kinase tel1Add BLAST2925

Proteomic databases

PRIDEiQ2U639.

Interactioni

Subunit structurei

Associates with DNA double-strand breaks.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2U639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1844 – 2467FATPROSITE-ProRule annotationAdd BLAST624
Domaini2597 – 2925PI3K/PI4KPROSITE-ProRule annotationAdd BLAST329
Domaini2893 – 2925FATCPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000176680.
OMAiANVLWDQ.
OrthoDBiEOG092C00SN.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 3 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2U639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEITLDRTL VLLSSEKQRE RSEGLAVSLF VLIVVFVIDP CISSRSSLND
60 70 80 90 100
KACHKIFESL FRFISSEKSL YNRGNSKGPS ASRLSTCASV LRLAVDALLH
110 120 130 140 150
NLRAKSVRAV VDHITETLQD TGGSLFELLG VDYTKCLTAL LNYPPHVEHL
160 170 180 190 200
GASEWEKLMG FCLKIMNTQD YEDDRSHTGS DSRSTLDDFL GTGGTPTPSR
210 220 230 240 250
SMPTLTAREK PKRDKGAISE AVVCIQLLTA SVNAPVQEPA AKILHGLVGY
260 270 280 290 300
VKSSHITGSG HQSAFNSINS VIMRVLSDQS ELVQSILLDL IPVICHLWAT
310 320 330 340 350
KLVGLKDELL VTIMLCIVLL TAATRQEPSE LLSRYTEDLL GALYKEYIKR
360 370 380 390 400
PEKDILQVDE LVFHQKTSAA VDKILIWPRL ESGKSEHNWT VIWAIANLVD
410 420 430 440 450
LSEEITARSS SPRTSTETLN KRQRLTSMVD EIHRDCASSS GARRVCALQL
460 470 480 490 500
IPLIPRHHAS VDSKSSLLLR LLPNILDENG ILASWTMITI ASLAGSPNAD
510 520 530 540 550
SPSLRAIWQQ AWELTCRAST SQATSRASCI LMNSILEYNL LEYSIVAEAT
560 570 580 590 600
SSMLTSVNLN GPSTMSDASL TLWATTTRMT ARVNPGSLPN ASKQICAWLR
610 620 630 640 650
EVWVIGTVTD RTQLAQLAAF ARPLDLLNLL LACTNRHYIP PKPQFRGATS
660 670 680 690 700
LIAKGWHFLH RSKQLLNYLF QLGGILDFDM WDTDDTIHLE TFPRQDPNDN
710 720 730 740 750
MVLDLLQVKS EMFLQAFQSL YEDKSHHVTV EIVQIVTSFC ILVALYTECL
760 770 780 790 800
PHLSASKFHN LQQNCERLWE IICTFLASHE LEFIQGCLVV LSPFLNPEQF
810 820 830 840 850
SYNPESTISK ALLRLVIPLV SLLEAYRRSQ RDNLALHNDE PMDLDDTLFN
860 870 880 890 900
SKDRLAEVTS IVKSNREALP LFQEFSSFQR CITIQLSVLQ KTNAFLRNHD
910 920 930 940 950
QHSSRALVEY LIDLDEVDIL AASNSLPYVY RAISGMDRTS LLDILEDLAE
960 970 980 990 1000
KCLQTYELER CEASHLLCIH MMHSFVKAWV SSEADSLSGS ASDIYTWFRD
1010 1020 1030 1040 1050
VLLAKDMASP SVLVVFSELL VDVINTNASY SSGESNTSPR TSLLKILEKG
1060 1070 1080 1090 1100
SIPVKFDVGN LIPRLFGHYS LNDHDAIFND VLRHLPKESD WVEGIALRLF
1110 1120 1130 1140 1150
ILGQLASRWH TLLRRSIYHM FETPAHVPHS LQYAEKCICD VANKLGLKDA
1160 1170 1180 1190 1200
KELFRLFSSQ ILYTWTEQES ITAMPFSIFS YASIKDMLGD VQDELVGQII
1210 1220 1230 1240 1250
MRAREDEEIE MSKYMGKPFV DLLATSFYKA EAYSIARDIS TPPGQGSQPK
1260 1270 1280 1290 1300
GVETRLKKIL GTEQFMELID QQFPQTIAAF FGSLDQYEQV ERALSKRAKF
1310 1320 1330 1340 1350
HDALDGLRCI LGKSASKIVL PANQQPSFRA RYLIDELEFL CKRSGYELET
1360 1370 1380 1390 1400
IWTPTLASYV CRTLLESIHP ALGSFHACSV IRKIRVLLCV AGSVMLRDYP
1410 1420 1430 1440 1450
FEMTLHAMLP FLVDIYCSED ALGIFWYLLE AGQPYLAETP GLMAGVAVST
1460 1470 1480 1490 1500
LLSLKKFLAS PPVDTAQQGQ SKIVTANIER FLQWFGEYIN TYESSLDAET
1510 1520 1530 1540 1550
QESFRRVVKS SQATSTVESH SDDSNERDVI LEILDDRSSE RSLLSKTVSD
1560 1570 1580 1590 1600
HVIALLCADS EEPLGNYHKL NESDRDATAN IVAIYQTLQS FNTGSGYRLW
1610 1620 1630 1640 1650
AAKVIGRAFA TTGKVCDALL REQDLSLFKS QLSDLRLEVH CYSKASILQE
1660 1670 1680 1690 1700
LCNMLQNNSH LEVGLVERTL QLIISNLARY PDFEQCAGVV PLYLMKAFTW
1710 1720 1730 1740 1750
DPYQCPPIPT LAPETERDDA KVNWQTSNSL SQWARGIALF LSKSAAEDPV
1760 1770 1780 1790 1800
IGSLSHIIYV IPELAVRILP YMLHDVLLAE LKGEANIRQK VSQIFKQALC
1810 1820 1830 1840 1850
DVHDTTISHA RLAIDCILYL RNQPKPNEAT IVERDEWLEI DFAEASLAAS
1860 1870 1880 1890 1900
RCRLPKTALI FLEIHASRVI FGSRRSSLAK YEAPPDMLHD IFKDIDDPDF
1910 1920 1930 1940 1950
FYGIQQSPSL DSVMERLQHE SSGFKNLLFQ SAQYDSEIQM SADQNAYGVL
1960 1970 1980 1990 2000
KALNSTNLQG IANSIFSASG GGFVDTSSSF DSMLQAATNL RQWDIPVSPL
2010 2020 2030 2040 2050
NPSPPATVFR AFQSLNTSGS LAEASKSINE CLLTTLESLT SASRSAMSLR
2060 2070 2080 2090 2100
TAMRVLGVIT EVSDVLDARS TEEIDHEWQK IAARDSWLKT TSVHEIGEIL
2110 2120 2130 2140 2150
NSHEALFSSI NRKSYLRSST NISDHDAQLL EVKAIRQSLH ITRTQGIQQA
2160 2170 2180 2190 2200
SLKSAVYLSK LAHQCSALGI NIEGAAKFDL ANVLWDQGEM TASIRMLHQL
2210 2220 2230 2240 2250
KDQNDLHKQA VPISRAELLV TLVSSLHIDS LRTKPCSFRT NSTSCKGHHV
2260 2270 2280 2290 2300
AEARLEKPET IIQDYLLTAV KELKGRSGGE EAGRVYHGFA TFCDQQLQNP
2310 2320 2330 2340 2350
DGLEDFTRVE QLRNRKEKEV RALEDMMKAA EGREREALKF HRGRTKQWFD
2360 2370 2380 2390 2400
LDDREYQRLR RSREAFLQQC LENYLLCLRE SETYNNDVLR FCALWLDKSD
2410 2420 2430 2440 2450
SDIANAAVSK HLGQVPSRKF APLMNQLTSR LLDVPDEFQK MLFSLITRIC
2460 2470 2480 2490 2500
VEHPFHGMYQ IFASSKSKGG KDETALSRNR AAGRLVEGLK NDKRIGPTWV
2510 2520 2530 2540 2550
AVHNTNINYV RFAIDRPDEK LKSGARVPLR KLQTGGRLEQ DAATQKLPPP
2560 2570 2580 2590 2600
TMNIEIRVDC DYRDVPKLVK YHPEFTIASG VSAPKIVSAF ASNGLRYKQL
2610 2620 2630 2640 2650
FKGGNDDLRQ DAIMEQVFEQ VSNLLKDHQA TRQRNLGIRT YKVLPLTSNA
2660 2670 2680 2690 2700
GIIEFVPHTI PLHDYLMPAH QKYYPKDMKP NVCRKHISDV QTRSFEQRVR
2710 2720 2730 2740 2750
TYRQVTEHFH PVMKYFFMEK FNNPDDWFSK RLSYTRSTAA ISILGHVLGL
2760 2770 2780 2790 2800
GDRHGHNILL DERTGEVVHI DLGVAFEQGR VLPVPEVVPF RLTRDLVDGM
2810 2820 2830 2840 2850
GVTKTEGVFR RCCEFTLETL RRESYSIMTI LDVLRYDPLY SWTVSPLRMK
2860 2870 2880 2890 2900
KMQDASEAGG GPPMLPGAAD QRPSNEPSEA DRALTVVAKK LGKTLSVTAT
2910 2920
VNELIQQATD EKNLAVLYCG WAAYA
Length:2,925
Mass (Da):328,517
Last modified:January 24, 2006 - v1
Checksum:iECE656F9A991F45E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007166 Genomic DNA. Translation: BAE62976.1.

Genome annotation databases

EnsemblFungiiBAE62976; BAE62976; AO090120000393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007166 Genomic DNA. Translation: BAE62976.1.

3D structure databases

ProteinModelPortaliQ2U639.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2U639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAE62976; BAE62976; AO090120000393.

Phylogenomic databases

HOGENOMiHOG000176680.
OMAiANVLWDQ.
OrthoDBiEOG092C00SN.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 3 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATM_ASPOR
AccessioniPrimary (citable) accession number: Q2U639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.