Reviewed, UniProtKB/Swiss-Prot Q2U639 (ATM_ASPOR)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase tel1
    EC=2.7.11.1
Alternative name(s):
    DNA-damage checkpoint kinase tel1
    Telomere length regulation protein 1
    ATM homolog

Gene names

Name:	tel1
ORF Names:	AO090120000393

Organism

Aspergillus oryzae [Complete proteome]

Taxonomic identifier

5062 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	2925 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Associates with DNA double-strand breaks By similarity.
Subcellular location	Nucleus By similarity. Telomere By similarity. Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. ATM subfamily. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Chromosomal protein Nucleus Telomere
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chromatin regulator Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2925	2925	Serine/threonine-protein kinase tel1		PRO_0000227697
Regions
	Domain	1844 – 2467	624	FAT
	Domain	2597 – 2925	329	PI3K/PI4K
	Domain	2893 – 2925	33	FATC

Sequences

	Sequence		Length	Mass (Da)
	Q2U639-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: ECE656F9A991F45E	FASTA	2,925	328,517
	10 20 30 40 50 60 MAEITLDRTL VLLSSEKQRE RSEGLAVSLF VLIVVFVIDP CISSRSSLND KACHKIFESL 70 80 90 100 110 120 FRFISSEKSL YNRGNSKGPS ASRLSTCASV LRLAVDALLH NLRAKSVRAV VDHITETLQD 130 140 150 160 170 180 TGGSLFELLG VDYTKCLTAL LNYPPHVEHL GASEWEKLMG FCLKIMNTQD YEDDRSHTGS 190 200 210 220 230 240 DSRSTLDDFL GTGGTPTPSR SMPTLTAREK PKRDKGAISE AVVCIQLLTA SVNAPVQEPA 250 260 270 280 290 300 AKILHGLVGY VKSSHITGSG HQSAFNSINS VIMRVLSDQS ELVQSILLDL IPVICHLWAT 310 320 330 340 350 360 KLVGLKDELL VTIMLCIVLL TAATRQEPSE LLSRYTEDLL GALYKEYIKR PEKDILQVDE 370 380 390 400 410 420 LVFHQKTSAA VDKILIWPRL ESGKSEHNWT VIWAIANLVD LSEEITARSS SPRTSTETLN 430 440 450 460 470 480 KRQRLTSMVD EIHRDCASSS GARRVCALQL IPLIPRHHAS VDSKSSLLLR LLPNILDENG 490 500 510 520 530 540 ILASWTMITI ASLAGSPNAD SPSLRAIWQQ AWELTCRAST SQATSRASCI LMNSILEYNL 550 560 570 580 590 600 LEYSIVAEAT SSMLTSVNLN GPSTMSDASL TLWATTTRMT ARVNPGSLPN ASKQICAWLR 610 620 630 640 650 660 EVWVIGTVTD RTQLAQLAAF ARPLDLLNLL LACTNRHYIP PKPQFRGATS LIAKGWHFLH 670 680 690 700 710 720 RSKQLLNYLF QLGGILDFDM WDTDDTIHLE TFPRQDPNDN MVLDLLQVKS EMFLQAFQSL 730 740 750 760 770 780 YEDKSHHVTV EIVQIVTSFC ILVALYTECL PHLSASKFHN LQQNCERLWE IICTFLASHE 790 800 810 820 830 840 LEFIQGCLVV LSPFLNPEQF SYNPESTISK ALLRLVIPLV SLLEAYRRSQ RDNLALHNDE 850 860 870 880 890 900 PMDLDDTLFN SKDRLAEVTS IVKSNREALP LFQEFSSFQR CITIQLSVLQ KTNAFLRNHD 910 920 930 940 950 960 QHSSRALVEY LIDLDEVDIL AASNSLPYVY RAISGMDRTS LLDILEDLAE KCLQTYELER 970 980 990 1000 1010 1020 CEASHLLCIH MMHSFVKAWV SSEADSLSGS ASDIYTWFRD VLLAKDMASP SVLVVFSELL 1030 1040 1050 1060 1070 1080 VDVINTNASY SSGESNTSPR TSLLKILEKG SIPVKFDVGN LIPRLFGHYS LNDHDAIFND 1090 1100 1110 1120 1130 1140 VLRHLPKESD WVEGIALRLF ILGQLASRWH TLLRRSIYHM FETPAHVPHS LQYAEKCICD 1150 1160 1170 1180 1190 1200 VANKLGLKDA KELFRLFSSQ ILYTWTEQES ITAMPFSIFS YASIKDMLGD VQDELVGQII 1210 1220 1230 1240 1250 1260 MRAREDEEIE MSKYMGKPFV DLLATSFYKA EAYSIARDIS TPPGQGSQPK GVETRLKKIL 1270 1280 1290 1300 1310 1320 GTEQFMELID QQFPQTIAAF FGSLDQYEQV ERALSKRAKF HDALDGLRCI LGKSASKIVL 1330 1340 1350 1360 1370 1380 PANQQPSFRA RYLIDELEFL CKRSGYELET IWTPTLASYV CRTLLESIHP ALGSFHACSV 1390 1400 1410 1420 1430 1440 IRKIRVLLCV AGSVMLRDYP FEMTLHAMLP FLVDIYCSED ALGIFWYLLE AGQPYLAETP 1450 1460 1470 1480 1490 1500 GLMAGVAVST LLSLKKFLAS PPVDTAQQGQ SKIVTANIER FLQWFGEYIN TYESSLDAET 1510 1520 1530 1540 1550 1560 QESFRRVVKS SQATSTVESH SDDSNERDVI LEILDDRSSE RSLLSKTVSD HVIALLCADS 1570 1580 1590 1600 1610 1620 EEPLGNYHKL NESDRDATAN IVAIYQTLQS FNTGSGYRLW AAKVIGRAFA TTGKVCDALL 1630 1640 1650 1660 1670 1680 REQDLSLFKS QLSDLRLEVH CYSKASILQE LCNMLQNNSH LEVGLVERTL QLIISNLARY 1690 1700 1710 1720 1730 1740 PDFEQCAGVV PLYLMKAFTW DPYQCPPIPT LAPETERDDA KVNWQTSNSL SQWARGIALF 1750 1760 1770 1780 1790 1800 LSKSAAEDPV IGSLSHIIYV IPELAVRILP YMLHDVLLAE LKGEANIRQK VSQIFKQALC 1810 1820 1830 1840 1850 1860 DVHDTTISHA RLAIDCILYL RNQPKPNEAT IVERDEWLEI DFAEASLAAS RCRLPKTALI 1870 1880 1890 1900 1910 1920 FLEIHASRVI FGSRRSSLAK YEAPPDMLHD IFKDIDDPDF FYGIQQSPSL DSVMERLQHE 1930 1940 1950 1960 1970 1980 SSGFKNLLFQ SAQYDSEIQM SADQNAYGVL KALNSTNLQG IANSIFSASG GGFVDTSSSF 1990 2000 2010 2020 2030 2040 DSMLQAATNL RQWDIPVSPL NPSPPATVFR AFQSLNTSGS LAEASKSINE CLLTTLESLT 2050 2060 2070 2080 2090 2100 SASRSAMSLR TAMRVLGVIT EVSDVLDARS TEEIDHEWQK IAARDSWLKT TSVHEIGEIL 2110 2120 2130 2140 2150 2160 NSHEALFSSI NRKSYLRSST NISDHDAQLL EVKAIRQSLH ITRTQGIQQA SLKSAVYLSK 2170 2180 2190 2200 2210 2220 LAHQCSALGI NIEGAAKFDL ANVLWDQGEM TASIRMLHQL KDQNDLHKQA VPISRAELLV 2230 2240 2250 2260 2270 2280 TLVSSLHIDS LRTKPCSFRT NSTSCKGHHV AEARLEKPET IIQDYLLTAV KELKGRSGGE 2290 2300 2310 2320 2330 2340 EAGRVYHGFA TFCDQQLQNP DGLEDFTRVE QLRNRKEKEV RALEDMMKAA EGREREALKF 2350 2360 2370 2380 2390 2400 HRGRTKQWFD LDDREYQRLR RSREAFLQQC LENYLLCLRE SETYNNDVLR FCALWLDKSD 2410 2420 2430 2440 2450 2460 SDIANAAVSK HLGQVPSRKF APLMNQLTSR LLDVPDEFQK MLFSLITRIC VEHPFHGMYQ 2470 2480 2490 2500 2510 2520 IFASSKSKGG KDETALSRNR AAGRLVEGLK NDKRIGPTWV AVHNTNINYV RFAIDRPDEK 2530 2540 2550 2560 2570 2580 LKSGARVPLR KLQTGGRLEQ DAATQKLPPP TMNIEIRVDC DYRDVPKLVK YHPEFTIASG 2590 2600 2610 2620 2630 2640 VSAPKIVSAF ASNGLRYKQL FKGGNDDLRQ DAIMEQVFEQ VSNLLKDHQA TRQRNLGIRT 2650 2660 2670 2680 2690 2700 YKVLPLTSNA GIIEFVPHTI PLHDYLMPAH QKYYPKDMKP NVCRKHISDV QTRSFEQRVR 2710 2720 2730 2740 2750 2760 TYRQVTEHFH PVMKYFFMEK FNNPDDWFSK RLSYTRSTAA ISILGHVLGL GDRHGHNILL 2770 2780 2790 2800 2810 2820 DERTGEVVHI DLGVAFEQGR VLPVPEVVPF RLTRDLVDGM GVTKTEGVFR RCCEFTLETL 2830 2840 2850 2860 2870 2880 RRESYSIMTI LDVLRYDPLY SWTVSPLRMK KMQDASEAGG GPPMLPGAAD QRPSNEPSEA 2890 2900 2910 2920 DRALTVVAKK LGKTLSVTAT VNELIQQATD EKNLAVLYCG WAAYA

References

[1]

"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed: 16372010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP007166 Genomic DNA. Translation: BAE62976.1.
RefSeq	XP_001824109.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5996469.
KEGG	aor:AO090120000393.
Enzyme and pathway databases
BRENDA	2.7.11.1. 2240.
Family and domain databases
InterPro	IPR015519. Ataxia_Telang_Mut. IPR003152. FATC. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR014009. PIK_FAT. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
PANTHER	PTHR11139:SF3. Ataxia_Telang_Mut. 1 hit.
Pfam	PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATM_ASPOR

Accession

Primary (citable) accession number: Q2U639

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)