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Q2U4X9 (LCPS_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:AO090020000159
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409233

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane91 – 11121Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane218 – 23821Helical; Potential
Region1 – 236236Lycopene beta-cyclase
Region243 – 587345Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
Q2U4X9 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 8BF7D3D45A03AA1D

FASTA58766,543
        10         20         30         40         50         60 
MGLDYILVHV TYNIPLAGIL TLVYWPFMTR LDWQKISTLV IISLVATIPW DSYLVRHRIW 

        70         80         90        100        110        120 
TYAPNGVIGW TLYDIPSEEV FFFIIQTYNT SLVYLILTRW LVLPMYLGTV ARKETLIGAS 

       130        140        150        160        170        180 
ILLLAISVGL IALCFGDHFT YFGMIITWAG PFLLIQWVFS SGFIIALPKL ELMVSITLPT 

       190        200        210        220        230        240 
LFLWTVDTIS INQGTWTVEA PTKLGVQLWS GMDIEEVLFF LITNIVIVFG LVCIDYAIAM 

       250        260        270        280        290        300 
ATCELVQSPQ AVQSFPSYFR VLARFVTNKY HPDKQFVASL RKAVDRLAAS SQSMYMGSAM 

       310        320        330        340        350        360 
FQGPFRIDLI LLYSFFRVAD DLVDESQDTE SARMIIEQCD QLLEAKFSHP ELFPFSPGYQ 

       370        380        390        400        410        420 
EAKHPAPPEL IAAIDSLPVS RLRLEHLKGL IEGFRTDLTF SAKPGSFPFV TESDLDTYAY 

       430        440        450        460        470        480 
HVASSVAASM LGLVVHHFPD HQFAINVFLR RRVVDAGERM GQTLQYINVA RDIARDAAIN 

       490        500        510        520        530        540 
RVYLPTTWLK QQGLGPEDVL ASPTDSRLEL VRDRLLDRAE FLSASAREEM KFLPDEVQGP 

       550        560        570        580 
FLATVDSYLE IGAALRRGMR PRTLDDKLRL PLGTRLWVAY RAMAWRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007167 Genomic DNA. Translation: BAE63386.1.
RefSeqXP_001824519.1. XM_001824467.1.

3D structure databases

ProteinModelPortalQ2U4X9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00006543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00006674; CADAORAP00006543; CADAORAG00006674.
GeneID5996605.
KEGGaor:AOR_1_284084.

Phylogenomic databases

eggNOGNOG47964.
KOK17841.
OMAEVFFFII.
OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
ProtoNetSearch...

Entry information

Entry nameLCPS_ASPOR
AccessionPrimary (citable) accession number: Q2U4X9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: January 24, 2006
Last modified: March 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways