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Q2U4X9

- LCPS_ASPOR

UniProt

Q2U4X9 - LCPS_ASPOR

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Protein
Bifunctional lycopene cyclase/phytoene synthase
Gene
AO090020000159
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:AO090020000159
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Transmembranei65 – 8521Helical; Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409233Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00006543.

Structurei

3D structure databases

ProteinModelPortaliQ2U4X9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 236236Lycopene beta-cyclase
Add
BLAST
Regioni243 – 587345Phytoene synthase
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47964.
KOiK17841.
OMAiEVFFFII.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.

Sequencei

Sequence statusi: Complete.

Q2U4X9-1 [UniParc]FASTAAdd to Basket

« Hide

MGLDYILVHV TYNIPLAGIL TLVYWPFMTR LDWQKISTLV IISLVATIPW    50
DSYLVRHRIW TYAPNGVIGW TLYDIPSEEV FFFIIQTYNT SLVYLILTRW 100
LVLPMYLGTV ARKETLIGAS ILLLAISVGL IALCFGDHFT YFGMIITWAG 150
PFLLIQWVFS SGFIIALPKL ELMVSITLPT LFLWTVDTIS INQGTWTVEA 200
PTKLGVQLWS GMDIEEVLFF LITNIVIVFG LVCIDYAIAM ATCELVQSPQ 250
AVQSFPSYFR VLARFVTNKY HPDKQFVASL RKAVDRLAAS SQSMYMGSAM 300
FQGPFRIDLI LLYSFFRVAD DLVDESQDTE SARMIIEQCD QLLEAKFSHP 350
ELFPFSPGYQ EAKHPAPPEL IAAIDSLPVS RLRLEHLKGL IEGFRTDLTF 400
SAKPGSFPFV TESDLDTYAY HVASSVAASM LGLVVHHFPD HQFAINVFLR 450
RRVVDAGERM GQTLQYINVA RDIARDAAIN RVYLPTTWLK QQGLGPEDVL 500
ASPTDSRLEL VRDRLLDRAE FLSASAREEM KFLPDEVQGP FLATVDSYLE 550
IGAALRRGMR PRTLDDKLRL PLGTRLWVAY RAMAWRK 587
Length:587
Mass (Da):66,543
Last modified:January 24, 2006 - v1
Checksum:i8BF7D3D45A03AA1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007167 Genomic DNA. Translation: BAE63386.1.
RefSeqiXP_001824519.1. XM_001824467.1.

Genome annotation databases

EnsemblFungiiCADAORAT00006674; CADAORAP00006543; CADAORAG00006674.
GeneIDi5996605.
KEGGiaor:AOR_1_284084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007167 Genomic DNA. Translation: BAE63386.1 .
RefSeqi XP_001824519.1. XM_001824467.1.

3D structure databases

ProteinModelPortali Q2U4X9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00006543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAORAT00006674 ; CADAORAP00006543 ; CADAORAG00006674 .
GeneIDi 5996605.
KEGGi aor:AOR_1_284084.

Phylogenomic databases

eggNOGi NOG47964.
KOi K17841.
OMAi EVFFFII.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.

Entry informationi

Entry nameiLCPS_ASPOR
AccessioniPrimary (citable) accession number: Q2U4X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: January 24, 2006
Last modified: March 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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