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Q2U469 (MPKC_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase mpkC

Short name=MAP kinase C
EC=2.7.11.24
Gene names
Name:mpkC
ORF Names:AO090020000466
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-170 and Tyr-172, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAE63646.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Mitogen-activated protein kinase mpkC
PRO_0000289715

Regions

Domain19 – 298280Protein kinase
Nucleotide binding25 – 339ATP By similarity
Motif170 – 1723TXY

Sites

Active site1401Proton acceptor By similarity
Binding site481ATP By similarity

Amino acid modifications

Modified residue1701Phosphothreonine By similarity
Modified residue1721Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2U469 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: 66631F37777D796E

FASTA34439,188
        10         20         30         40         50         60 
MEFIRAEILG TTFETTSRYA NVQPVGLGAF GLVCSAYDQI TQQHVAVKKM MNPFANASIA 

        70         80         90        100        110        120 
KRTYREVKLL KQLRHENLIG LCDIFISPLE DIYLVTELLG TDLGRLLRAR PLDNKFAQYF 

       130        140        150        160        170        180 
MYQILRGLKY IHSAGVIHRD LKPSNLLVNE NCDLKICDFG LARVQEPQMT GYVSTRYYRA 

       190        200        210        220        230        240 
PEIMLTWQRY GKMVDIWSAG CILAEMLRGK PLFPGKDHIH QFFLITEVLG NPPPEVVQKI 

       250        260        270        280        290        300 
TSGNTQRVVN SLPNQEPRPL RAVFHEFDND VISLLEQLLL FDPDKRLTAE TALQHPYLAP 

       310        320        330        340 
YHDPDDEPAA LEKFDWSFND ADLPIDTWKL MMCVAIGSAK CAPN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007167 Genomic DNA. Translation: BAE63646.1. Sequence problems.

3D structure databases

ProteinModelPortalQ2U469.
SMRQ2U469. Positions 2-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00006803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPKC_ASPOR
AccessionPrimary (citable) accession number: Q2U469
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 16, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families