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Q2U100

- M2DH_ASPOR

UniProt

Q2U100 - M2DH_ASPOR

Protein

Mannitol 2-dehydrogenase

Gene

AO090011000230

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

    Catalytic activityi

    D-mannitol + NAD+ = D-fructose + NADH.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 4812NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:AO090011000230
    OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
    Taxonomic identifieri510516 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006564: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371542Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi5062.CADAORAP00004923.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2U100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannitol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000202982.
    KOiK00045.
    OMAiPWELMKI.
    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2U100-1 [UniParc]FASTAAdd to Basket

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    MAPLKLNNKN LSQIAAAGET QVKVPTYKRG GDVKEGIVHV GVGGFHRAHL    50
    AVYVDQLMQK HGVTDYAICG VGLQPFDAAM RDALGSQDHL YTVIERSAKG 100
    SFAHVVGSIN SYLFAPDNRE AVIAKMAHPD THIVSLTITE SGYYYNENTH 150
    ELQSEHPDIQ FDLQPANEKS PRTTFGFLYA ALARRYQQGL KPFTVMSCDN 200
    MQKNGSITRH MLESFARLRN PEIAKWIAEQ GAFPNAMVDR ITPQTSATDK 250
    TALADNFAIE DSWPVVTEPF MQWVIEDQFS DGRPPFEKVG AQVVKNVHDV 300
    EEFEKHKLRL LNGSHSAIGY PGQLAGFKYV HEVMENPLFS KFVWQMMQDE 350
    VKPLLPEIPG VNIDEYCKTL IERFSNPTIM DQLPRICLNA SGKIPQFIMP 400
    SIAEAIWVTG PFRRLCFVAA AWFHYINGVD DSGKKFEVDD PMREELQAKA 450
    RAGGTSPAEL LSIKSLFGDD LRGDKRFLQE ITKAMEDIAR DGILKTLPKY 500
    ID 502
    Length:502
    Mass (Da):56,251
    Last modified:January 24, 2006 - v1
    Checksum:iB34B1957B39B630E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007171 Genomic DNA. Translation: BAE64765.1.
    RefSeqiXP_001825898.1. XM_001825846.2.

    Genome annotation databases

    EnsemblFungiiCADAORAT00005013; CADAORAP00004923; CADAORAG00005013.
    GeneIDi5998001.
    KEGGiaor:AOR_1_380054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007171 Genomic DNA. Translation: BAE64765.1 .
    RefSeqi XP_001825898.1. XM_001825846.2.

    3D structure databases

    ProteinModelPortali Q2U100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5062.CADAORAP00004923.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAORAT00005013 ; CADAORAP00004923 ; CADAORAG00005013 .
    GeneIDi 5998001.
    KEGGi aor:AOR_1_380054.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000202982.
    KOi K00045.
    OMAi PWELMKI.
    OrthoDBi EOG7PCJRT.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of Aspergillus oryzae."
      Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
      , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
      Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42149 / RIB 40.

    Entry informationi

    Entry nameiM2DH_ASPOR
    AccessioniPrimary (citable) accession number: Q2U100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3