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Q2U100 (M2DH_ASPOR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:AO090011000230
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) [Complete proteome]
Taxonomic identifier510516 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from direct assay PubMed 22341915. Source: ASPGD

   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Mannitol 2-dehydrogenase
PRO_0000371542

Regions

Nucleotide binding37 – 4812NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2U100 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: B34B1957B39B630E

FASTA50256,251
        10         20         30         40         50         60 
MAPLKLNNKN LSQIAAAGET QVKVPTYKRG GDVKEGIVHV GVGGFHRAHL AVYVDQLMQK 

        70         80         90        100        110        120 
HGVTDYAICG VGLQPFDAAM RDALGSQDHL YTVIERSAKG SFAHVVGSIN SYLFAPDNRE 

       130        140        150        160        170        180 
AVIAKMAHPD THIVSLTITE SGYYYNENTH ELQSEHPDIQ FDLQPANEKS PRTTFGFLYA 

       190        200        210        220        230        240 
ALARRYQQGL KPFTVMSCDN MQKNGSITRH MLESFARLRN PEIAKWIAEQ GAFPNAMVDR 

       250        260        270        280        290        300 
ITPQTSATDK TALADNFAIE DSWPVVTEPF MQWVIEDQFS DGRPPFEKVG AQVVKNVHDV 

       310        320        330        340        350        360 
EEFEKHKLRL LNGSHSAIGY PGQLAGFKYV HEVMENPLFS KFVWQMMQDE VKPLLPEIPG 

       370        380        390        400        410        420 
VNIDEYCKTL IERFSNPTIM DQLPRICLNA SGKIPQFIMP SIAEAIWVTG PFRRLCFVAA 

       430        440        450        460        470        480 
AWFHYINGVD DSGKKFEVDD PMREELQAKA RAGGTSPAEL LSIKSLFGDD LRGDKRFLQE 

       490        500 
ITKAMEDIAR DGILKTLPKY ID 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP007171 Genomic DNA. Translation: BAE64765.1.
RefSeqXP_001825898.1. XM_001825846.2.

3D structure databases

ProteinModelPortalQ2U100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5062.CADAORAP00004923.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAORAT00005013; CADAORAP00004923; CADAORAG00005013.
GeneID5998001.
KEGGaor:AOR_1_380054.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000202982.
KOK00045.
OMAFEKVGVQ.
OrthoDBEOG7PCJRT.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_ASPOR
AccessionPrimary (citable) accession number: Q2U100
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 24, 2006
Last modified: December 11, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families