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Protein

Probable cutinase 2

Gene

AO090011000665

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Seems, in this nonpathogenic fungi, to play an important role in flavor formation (By similarity).By similarity

Catalytic activityi

Cutin + H2O = cutin monomers.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261By similarity
Active sitei181 – 1811By similarity
Active sitei194 – 1941By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERiaspor-cuti2. Cutinase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cutinase 2 (EC:3.1.1.74)
Alternative name(s):
Cutin hydrolase 2
Gene namesi
ORF Names:AO090011000665
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiFungiDB:AO090011000665.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 221205Probable cutinase 2PRO_0000233111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 184By similarity
Disulfide bondi115 ↔ 177By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ2TZY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cutinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000171425.
OMAiTRNAQEH.
OrthoDBiEOG092C4OIR.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00155. CUTINASE_1. 1 hit.
PS00931. CUTINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TZY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRLLTLAL AAVAAASPVD IQERQLSGGN ELRDGSCKPI TFIFARASTE
60 70 80 90 100
PGLLGISTGP AVCNGLKMAK AGQVACQGVG PKYTADLASN ALPENTSPAA
110 120 130 140 150
IQEAQDLFQQ AVTKCPDTQI VAGGYSQGTA VMDDSIKRLP DNVKEKIKGV
160 170 180 190 200
VLFGYTRNAQ EHGQIANFPK DKVKVYCAVG DMVCDGTLIV GPAHFTYLGN
210 220
TGEATQFLLG YLRFLQLTQL P
Length:221
Mass (Da):23,361
Last modified:January 24, 2006 - v1
Checksum:i9D468CD6A7AE8B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007171 Genomic DNA. Translation: BAE65128.1.

Genome annotation databases

EnsemblFungiiCADAORAT00005387; CADAORAP00005286; CADAORAG00005387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007171 Genomic DNA. Translation: BAE65128.1.

3D structure databases

ProteinModelPortaliQ2TZY7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspor-cuti2. Cutinase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00005387; CADAORAP00005286; CADAORAG00005387.

Organism-specific databases

EuPathDBiFungiDB:AO090011000665.

Phylogenomic databases

HOGENOMiHOG000171425.
OMAiTRNAQEH.
OrthoDBiEOG092C4OIR.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00155. CUTINASE_1. 1 hit.
PS00931. CUTINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUTI2_ASPOR
AccessioniPrimary (citable) accession number: Q2TZY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.