Reviewed, UniProtKB/Swiss-Prot Q2TZN9 (ADA_ASPOR)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	aah1
ORF Names:	AO090011000781

Organism

Aspergillus oryzae [Complete proteome]

Taxonomic identifier

5062 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Adenosine deaminase		PRO_0000256231
Sites
	Active site	208	1	Potential
	Active site	255	1	Potential
	Active site	288	1	Potential
	Active site	289	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2TZN9-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 4F2F9B1CEEA7EBD3	FASTA	351	39,718
	10 20 30 40 50 60 MCKSDLHDFL HGLPKCEHHV HLEGCLAPDL IFELAKRNNV SLPNEPAYES IEALSHRYGH 70 80 90 100 110 120 FTSLDDFLRF YFIGMSVLHH ESDFADLAWA YFQKAHADGV HHAEVFFDPQ VHRDRGIPYE 130 140 150 160 170 180 TIVSGFVAGC QRAERELGLT TRLILCFVRH LPVDNAARVY QEALDQEHFD NEVVHGLGWS 190 200 210 220 230 240 STEVGPPKDM FRELYSSASA KGIRLTAHAG EEGDPSYISA ALELGAQRID HGIRLVEDPV 250 260 270 280 290 300 LMEKVVRDRI MLTVCPISNL QLRCVESIAH VPIRKFLDAG VMFSINSDDP AYFGGYILDN 310 320 330 340 350 YCAVQEAFQL TVDEWRVIAE NSIKGSWIGE ERKTELLKRI DDHVQRHVAA V

References

[1]

"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed: 16372010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP007171 Genomic DNA. Translation: BAE65226.1.
RefSeq	XP_001826359.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5998462.
GenomeReviews	Gene locus aah1 in contig AP007171_GR.
KEGG	aor:AO090011000781.
Enzyme and pathway databases
BRENDA	3.5.4.4. 2240.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADA_ASPOR

Accession

Primary (citable) accession number: Q2TZN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 24, 2006
Last modified:	September 22, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)