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Q2TXB7

- MANBB_ASPOR

UniProt

Q2TXB7 - MANBB_ASPOR

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Protein
Beta-mannosidase B
Gene
mndB, AO090010000208
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers manobiose over mannotriose and has no activity against polymeric mannan. Is also severly restricetd by galactosyl substitutions at the +1 subsite By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei432 – 4321Proton donor By similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. mannan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase B (EC:3.2.1.25)
Alternative name(s):
Mannanase B
Short name:
Mannase B
Gene namesi
Name:mndB
ORF Names:AO090010000208
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006564: Chromosome 8

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Beta-mannosidase B
PRO_0000394656Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00004234.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000186861.
KOiK01192.
OrthoDBiEOG7NSB9Q.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view]
PANTHERiPTHR10066:SF12. PTHR10066:SF12. 1 hit.
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2TXB7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAFSQYPLS TGWSFKDSDD QSPEAWMPVP VVPSVAHQDL QANQKLKNPY    50
IGFNELDARW VNDKSWTYRT VFQKPAVAAG SSIILAFDGL DTFATVKLDG 100
SVILQSDNMF LAHRVDVTKA LEAEGDHVLE IDFDCAMRRA RELREKDTKH 150
NWASFNGDPA RMAVRKAQYH WGWDWGPLLS TAGIWREVRL EVYSAKISDL 200
WTEVELASDH QTARVSAFAE VDAADSVDSY KASFLLSLHG KEVAREVATL 250
KDKVANVTFD VTQPSLWWPN GYGDPALYEI SVSLEKEDCE IHSVSKKIGI 300
RTAELIQQPD RHGKSFFFRI NGVDVFCGGS CWIPADNLLP SITAERYRKW 350
IELMVAGRQV MIRVWGGGCY EDDSFYQACD ELGVLVWQDF MFGCGNYPTW 400
PELLESIEKE ANYNVRRLRH HPSIVVYVGN NEDYQVQESA GLVYDYEDKN 450
PENWLKTDFP ARYIYEKLLP SVVEKLSPKT VYHPGSPWGD GKITSDPTVG 500
DMHQWNVWHG TQEKYQIFDT LGGRFNSEFG MEAFPHMSTI EYFVENEADK 550
YPQSHVLDFH NKADGHERRI ATYLVENLRT ATDLETYVYL TQVVQAETMM 600
FGYRGWRRQW GDERHCGGAL LWQLNDCWPT ISWAIVDYFL RPKPAFYAVA 650
RVLKPIAVGV RREHHDWSVT HAQPPKTSKY ELWIASSLQK ETVGTIELRF 700
LSVNTGLDVR APILRDNVKI VPNGTTNILE GVIDHKAQPE PHVLAARLWV 750
DGEVTARDVD WPQPFKYLDL SDRGLEVNKV SESGNEQKLL ITAKKPVKCL 800
VFEERDGIRV SDSAMDIVPG DGQTVTVTGL KAGDAPLKYK YLGQ 844
Length:844
Mass (Da):95,960
Last modified:March 19, 2014 - v3
Checksum:i4FBC82ACDB12075A
GO

Sequence cautioni

The sequence BAE66106.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007175 Genomic DNA. Translation: BAE66106.1. Sequence problems.
RefSeqiXP_001827239.2. XM_001827187.2.

Genome annotation databases

GeneIDi5999373.
KEGGiaor:AOR_1_372024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007175 Genomic DNA. Translation: BAE66106.1 . Sequence problems.
RefSeqi XP_001827239.2. XM_001827187.2.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 5062.CADAORAP00004234.

Chemistry

ChEMBLi CHEMBL4155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5999373.
KEGGi aor:AOR_1_372024.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000186861.
KOi K01192.
OrthoDBi EOG7NSB9Q.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view ]
PANTHERi PTHR10066:SF12. PTHR10066:SF12. 1 hit.
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequencing and analysis of Aspergillus oryzae."
    Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.
    , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H.
    Nature 438:1157-1161(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42149 / RIB 40.
  2. "Phylogenetic analysis and substrate specificity of GH2 beta-mannosidases from Aspergillus species."
    Reddy S.K., Rosengren A., Klaubauf S., Kulkarni T., Karlsson E.N., de Vries R.P., Stalbrand H.
    FEBS Lett. 587:3444-3449(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE MODEL REVISION.

Entry informationi

Entry nameiMANBB_ASPOR
AccessioniPrimary (citable) accession number: Q2TXB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 19, 2014
Last modified: September 3, 2014
This is version 55 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to clade A beta-mannosidases, which are likely secreted, clade B proteins appear to be intracellular By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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