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Protein

Catalase-peroxidase

Gene

katG

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi282 – 2821Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3448. AorCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:AO090010000722
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiFungiDB:AO090010000722.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Catalase-peroxidasePRO_0000354102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 241Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-267)UniRule annotation
Cross-linki241 ↔ 267Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2TW34.
SMRiQ2TW34. Positions 18-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TW34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKCPFHNQ APKPNVAGSG TQNRDWWPDQ LKLNILRQHT TVSNPLDPDF
60 70 80 90 100
DYAAAFNSLD YYALKKDLQD LMTDSQDWWP ADFGHYGGLF IRMAWHSAGT
110 120 130 140 150
YRTFDGRGGG GQGQQRFAPL NSWPDNVSLD KARRLLWPIK QKYGNKISWA
160 170 180 190 200
DLMILTGNVA LESMGFKTFG FAGGRKDTWE ADESVYWGGE TTWLGNDVRY
210 220 230 240 250
SHGFAGSSKH GAVIADEASH RDIHSRELEK PLAAAHMGLI YVNPEGPDGN
260 270 280 290 300
PDPVAAARDI RTTFARMAMN DEETVALIAG GHTFGKTHGA ASSDHVGSEP
310 320 330 340 350
EAAGLEAQGL GWQNSHGSGK GAHTITSGLE VTWTKTPTQW NLNFLEYLFR
360 370 380 390 400
FEWVLTKSPA GANQWVAKDA DAFIPDAYDS SKKHRPQMLT TDLSLRFDPA
410 420 430 440 450
YEKISRRFLE NPDQFAEAFA RAWFKLTHRD MGPRARYIGP EVPAEELSWQ
460 470 480 490 500
DPIPAVNHPV ISETDIAALK RDILATGVDP SKFISTAWAS ASTFRGSDKR
510 520 530 540 550
GGANGARIRL APQRDWEVNN QPWLAAALKA LEDIQDKFNS AQNDGKRVSL
560 570 580 590 600
ADLIVLAGCA AVEKAASDAG HIITVPFTPG RMDASQDQTD VESFNQMEPV
610 620 630 640 650
ADGFRNYGTS TARVPAEHYL VDKAQLLTLS APEMTVLVGG LRALNANYDG
660 670 680 690 700
SAHGVFTTRP GQLTNDFFVN LLDMNTSWKA SGSGNDIYEG TDRRTGSKKW
710 720 730 740 750
TATRADLVFG SHAELRAIAE VYGSSDGKGK FVKDFVAAWA KVMNLDRFDV

N
Length:751
Mass (Da):82,628
Last modified:January 24, 2006 - v1
Checksum:iFFB1094AA4A555E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007175 Genomic DNA. Translation: BAE66539.1.
RefSeqiXP_001827672.1. XM_001827620.2.

Genome annotation databases

EnsemblFungiiCADAORAT00004753; CADAORAP00004667; CADAORAG00004753.
GeneIDi5999806.
KEGGiaor:AOR_1_1214024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007175 Genomic DNA. Translation: BAE66539.1.
RefSeqiXP_001827672.1. XM_001827620.2.

3D structure databases

ProteinModelPortaliQ2TW34.
SMRiQ2TW34. Positions 18-750.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3448. AorCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAORAT00004753; CADAORAP00004667; CADAORAG00004753.
GeneIDi5999806.
KEGGiaor:AOR_1_1214024.

Organism-specific databases

EuPathDBiFungiDB:AO090010000722.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_ASPOR
AccessioniPrimary (citable) accession number: Q2TW34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.