Q2TVT4 (KGFL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative keratinocyte growth factor-like protein 1
Short name=KGF-like protein 1

Gene names

Name:

KGFLP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the heparin-binding growth factors family.
Caution	Could be the product of a pseudogene. Highly similar to the C-terminus of FGF7 but lacks the N-terminal part. As it has lost it signal peptide it is unlikely to be active. Maps to a duplicated region on chromosome 9.

Ontologies

Keywords
Molecular function	Growth factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 97	97	Putative keratinocyte growth factor-like protein 1		PRO_0000348938

Sequences

	Sequence		Length	Mass (Da)
	Q2TVT4 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 4F21D6A103ACF9D9	FASTA	97	11,079
	10 20 30 40 50 60 MEIRTVAVRI VAIKGVESEF YLAMNEEGKL YAKKECNEDC NFKELILENH YNTYAAAKWT 70 80 90 HNGGEMFVAL NQKGIPVRGK KTKKEQKTAH FLPMAIT

References

[1]	"Expression of keratinocyte growth factor (KGF) is regulated by two KGF-like proteins, KGFLP1 and KGFLP2." Huang T.-J., Lee C.-J. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer." Yasuhara T., Okamoto A., Kitagawa T., Nikaido T., Yoshimura T., Yanaihara N., Takakura S., Tanaka T., Ochiai K., Ohtake Y. Int. J. Oncol. 26:1209-1216(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY098593 mRNA. Translation: AAM34503.1.
IPI	IPI00887858.
UniGene	Hs.439341. Hs.732660.
3D structure databases
HSSP	HSSP built from PDB template 2AQZ based on UniProtKB P05230.
ProteinModelPortal	Q2TVT4.
ModBase	Search...
Polymorphism databases
DMDM	121941888.
Proteomic databases
PRIDE	Q2TVT4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC09P046688.
HPA	HPA043605.
neXtProt	NX_Q2TVT4.
Phylogenomic databases
HOVERGEN	HBG007580.
InParanoid	Q2TVT4.
Gene expression databases
Genevestigator	Q2TVT4.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGFL1_HUMAN

Accession

Primary (citable) accession number: Q2TVT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.