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Q2TVT4 (KGFL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative keratinocyte growth factor-like protein 1

Short name=KGF-like protein 1
Gene names
Name:KGFLP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Sequence similarities

Belongs to the heparin-binding growth factors family.

Caution

Could be the product of a pseudogene. Highly similar to the C-terminus of FGF7 but lacks the N-terminal part. As it has lost it signal peptide it is unlikely to be active. Maps to a duplicated region on chromosome 9.

Ontologies

Keywords
   Molecular functionGrowth factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9797Putative keratinocyte growth factor-like protein 1
PRO_0000348938

Sequences

Sequence LengthMass (Da)Tools
Q2TVT4 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 4F21D6A103ACF9D9

FASTA9711,079
        10         20         30         40         50         60 
MEIRTVAVRI VAIKGVESEF YLAMNEEGKL YAKKECNEDC NFKELILENH YNTYAAAKWT 

        70         80         90 
HNGGEMFVAL NQKGIPVRGK KTKKEQKTAH FLPMAIT 

« Hide

References

[1]"Expression of keratinocyte growth factor (KGF) is regulated by two KGF-like proteins, KGFLP1 and KGFLP2."
Huang T.-J., Lee C.-J.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer."
Yasuhara T., Okamoto A., Kitagawa T., Nikaido T., Yoshimura T., Yanaihara N., Takakura S., Tanaka T., Ochiai K., Ohtake Y.
Int. J. Oncol. 26:1209-1216(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY098593 mRNA. Translation: AAM34503.1.
UniGeneHs.439341.
Hs.732660.

3D structure databases

ProteinModelPortalQ2TVT4.
SMRQ2TVT4. Positions 1-97.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM121941888.

Proteomic databases

PRIDEQ2TVT4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC09P046688.
HPAHPA043605.
neXtProtNX_Q2TVT4.

Phylogenomic databases

HOVERGENHBG007580.
InParanoidQ2TVT4.

Gene expression databases

GenevestigatorQ2TVT4.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGFL1_HUMAN
AccessionPrimary (citable) accession number: Q2TVT4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 24, 2006
Last modified: January 22, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM