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Protein

Transient receptor potential cation channel subfamily M member 1

Gene

Trpm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel.3 Publications

GO - Molecular functioni

  • calcium channel activity Source: UniProtKB
  • cation channel activity Source: MGI

GO - Biological processi

  • calcium ion transport into cytosol Source: UniProtKB
  • cellular response to light stimulus Source: UniProtKB
  • G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  • protein tetramerization Source: InterPro
  • retinal rod cell development Source: MGI
  • signal transduction Source: MGI
  • visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Enzyme and pathway databases

ReactomeiR-MMU-3295583. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 1
Alternative name(s):
Long transient receptor potential channel 1
Short name:
LTrpC1
Melastatin-1
Gene namesi
Name:Trpm1Imported
Synonyms:Ltrpc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1330305. Trpm1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 790ExtracellularSequence analysisAdd BLAST790
Transmembranei791 – 811HelicalSequence analysisAdd BLAST21
Topological domaini812 – 875CytoplasmicSequence analysisAdd BLAST64
Transmembranei876 – 896HelicalSequence analysisAdd BLAST21
Topological domaini897ExtracellularSequence analysis1
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Topological domaini919 – 942CytoplasmicSequence analysisAdd BLAST24
Transmembranei943 – 963HelicalSequence analysisAdd BLAST21
Topological domaini964 – 973ExtracellularSequence analysis10
Transmembranei974 – 994HelicalSequence analysisAdd BLAST21
Topological domaini995 – 1006CytoplasmicSequence analysisAdd BLAST12
Transmembranei1007 – 1027HelicalSequence analysisAdd BLAST21
Topological domaini1028 – 1099ExtracellularSequence analysisAdd BLAST72
Transmembranei1100 – 1120HelicalSequence analysisAdd BLAST21
Topological domaini1121 – 1150CytoplasmicSequence analysisAdd BLAST30
Transmembranei1151 – 1171HelicalSequence analysisAdd BLAST21
Topological domaini1172 – 1622ExtracellularSequence analysisAdd BLAST451

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • new growing cell tip Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289311 – 1622Transient receptor potential cation channel subfamily M member 1Add BLAST1622

Proteomic databases

PaxDbiQ2TV84.
PRIDEiQ2TV84.

PTM databases

iPTMnetiQ2TV84.
PhosphoSitePlusiQ2TV84.

Expressioni

Tissue specificityi

Expressed in the retina where it localizes on dendritic tips of ON bipolar cells. Not detected in brain, lung, liver, heart, kidney, spleen or small intestine. Also expressed at high levels in poorly metastatic variants of B16 melanoma and at much reduced levels in highly metastatic variants of B16 melanoma.3 Publications

Gene expression databases

BgeeiENSMUSG00000030523.
ExpressionAtlasiQ2TV84. baseline and differential.
GenevisibleiQ2TV84. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082318.

Structurei

3D structure databases

ProteinModelPortaliQ2TV84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1224 – 1252Sequence analysisAdd BLAST29

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.
HOVERGENiHBG055663.
InParanoidiQ2TV84.
KOiK04976.
PhylomeDBiQ2TV84.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029588. TRPM1.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF13. PTHR13800:SF13. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q2TV84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSMRKMSSS FKRGSIKSST SGSQKGQKAW IEKTFCKREC IFVIPSTKDP
60 70 80 90 100
NRCCCGQLTN QHIPPLPSGA PSTTGEDTKQ ADTQSGKWSV SKHTQSYPTD
110 120 130 140 150
SYGILEFQGG GYSNKAMYIR VSYDTKPDSL LHLMVKDWQL ELPKLLISVH
160 170 180 190 200
GGLQSFEMQP KLKQVFGKGL IKAAMTTGAW IFTGGVSTGV VSHVGDALKD
210 220 230 240 250
HSSKSRGRLC AIGIAPWGMV ENKEDLIGKD VTRVYQTMSN PLSKLSVLNN
260 270 280 290 300
SHTHFILADN GTLGKYGAEV KLRRQLEKHI SLQKINTRLG QGVPVVGLVV
310 320 330 340 350
EGGPNVVSIV LEYLKEDPPV PVVVCDGSGR ASDILSFAHK YCDEGGVINE
360 370 380 390 400
SLRDQLLVTI QKTFNYSKSQ SYQLFAIIME CMKKKELVTV FRMGSEGQQD
410 420 430 440 450
VEMAILTALL KGTNASAPDQ LSLALAWNRV DIARSQIFVF GPHWPPLGSL
460 470 480 490 500
APPVDTKATE KEKKPPTATT KGRGKGKGKK KGKVKEEVEE ETDPRKLELL
510 520 530 540 550
NWVNALEQAM LDALVLDRVD FVKLLIENGV NMQHFLTIPR LEELYNTRLG
560 570 580 590 600
PPNTLHLLVR DVKKSNLPPD YHISLIDIGL VLEYLMGGAY RCNYTRKSFR
610 620 630 640 650
TLYNNLFGPK RPKALKLLGM EDDEPPAKGK KKKKKKKEEE IDIDVDDPAV
660 670 680 690 700
SRFQYPFHEL MVWAVLMKRQ KMAVFLWQRG EECMAKALVA CKLYKAMAHE
710 720 730 740 750
SSESELVDDI SQDLDNNSKD FGQLAVELLD QSYKHDEQVA MKLLTYELKN
760 770 780 790 800
WSNSTCLKLA VAAKHRDFIA HTCSQMLLTD MWMGRLRMRK NPGLKVIMGI
810 820 830 840 850
LIPPTILFLE FRTYDDFSYQ TSKENEDGKE KEEENVDANA DAGSRKGDEE
860 870 880 890 900
NEHKKQRSIP IGTKICEFYN APIVKFWFYT ISYLGYLLLF NYVILVRMDG
910 920 930 940 950
WPSPQEWIVI SYIVSLALEK IREILMSEPG KLSQKIKVWL QEYWNITDLV
960 970 980 990 1000
AISMFMVGAI LRLQSQPYMG YGRVIYCVDI ILWYIRVLDI FGVNKYLGPY
1010 1020 1030 1040 1050
VMMIGKMMID MLYFVVIMLV VLMSFGVARQ AILHPEEKPS WKLARNIFYM
1060 1070 1080 1090 1100
PYWMIYGEVF ADQIDLYAME INPPCGENLY DEEGKRLPPC IPGAWLTPAL
1110 1120 1130 1140 1150
MACYLLVANI LLVNLLIAVF NNTFFEVKSI SNQVWKFQRY QLIMTFHDRP
1160 1170 1180 1190 1200
VLPPPMIILS HIYIIIMRLS GRCRKKREGD QEERDRGLKL FLSDEELKKL
1210 1220 1230 1240 1250
HEFEEQCVQE HFREKEDEQQ SSSDERIRVT SERVENMSMR LEEINERENF
1260 1270 1280 1290 1300
MKTSLQTVDL RLSQLEELSG RMVSALENLA GIDRSDLIQA RSRASSECEA
1310 1320 1330 1340 1350
TYLLRQSSIN SADGYSLYRY HFNGEELLFE EPALSTSPGT AFRKKTYSFR
1360 1370 1380 1390 1400
VKDEDAKSHL DQPSNLHHTP GPSPPATPGR SRLALEGPLS TELRPGSDPG
1410 1420 1430 1440 1450
ISAGEFDPRA DFKSTEAAPS LNAAGVTGTQ LTVESTDSHP LRESKLVRYY
1460 1470 1480 1490 1500
PGDPNTYKTM KSRSFVYTEG RKLVRGLSNW SAEYSSIMDQ AWNATEWRCQ
1510 1520 1530 1540 1550
VQRITRSRST DIPYIVSEAA SQDELEDEHR GSLLDPQISR SALTVSDRPE
1560 1570 1580 1590 1600
KENLLSVKPH QTLGFPCLRS RSLHGRPRSA EPAPSKLDRA GHASSTSNLA
1610 1620
VMSVVPEGQN TQQEKRSAET EC
Note: No experimental confirmation available.Curated
Length:1,622
Mass (Da):183,527
Last modified:April 8, 2008 - v2
Checksum:iFB4786BD92D4ED5E
GO
Isoform 21 Publication (identifier: Q2TV84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: G → A
     190-1073: Missing.

Show »
Length:738
Mass (Da):82,761
Checksum:iC6E3B0F989EC9553
GO
Isoform 32 Publications (identifier: Q2TV84-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     612-658: PKALKLLGME...AVSRFQYPFH → VELSRHTVSC...SQTDITPPLP
     659-1622: Missing.

Show »
Length:542
Mass (Da):60,175
Checksum:iC03217ED13695993
GO
Isoform 42 Publications (identifier: Q2TV84-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     504-559: NALEQAMLDA...GPPNTLHLLV → CAHVLVSLPV...LHGNSVFTSM
     560-1622: Missing.

Show »
Length:443
Mass (Da):48,351
Checksum:iA688891BA62D1D9D
GO
Isoform 51 Publication (identifier: Q2TV84-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     504-559: NALEQAMLDA...GPPNTLHLLV → CAHVLVSLPV...LHGNSVFTSM
     560-1622: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:426
Mass (Da):46,318
Checksum:iD27C1FD1E6D37CCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160P → S in AAC13683 (PubMed:9537257).Curated1
Sequence conflicti246S → Y in BAE28794 (PubMed:16141072).Curated1
Sequence conflicti459T → A in AAC13683 (PubMed:9537257).Curated1
Sequence conflicti459T → A in BAE28340 (PubMed:16141072).Curated1
Sequence conflicti459T → A in BAE28448 (PubMed:16141072).Curated1
Sequence conflicti459T → A in BAE28453 (PubMed:16141072).Curated1
Sequence conflicti1481S → G in CAI30140 (PubMed:9537257).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0527511 – 133Missing in isoform 5. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_0527521 – 116Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST116
Alternative sequenceiVSP_052753189G → A in isoform 2. 1 Publication1
Alternative sequenceiVSP_052754190 – 1073Missing in isoform 2. 1 PublicationAdd BLAST884
Alternative sequenceiVSP_052755504 – 559NALEQ…LHLLV → CAHVLVSLPVCLQSSGLAFP KFSGRDSLVTFASSLPGWGT DGLMSILHGNSVFTSM in isoform 4 and isoform 5. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_052756560 – 1622Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST1063
Alternative sequenceiVSP_052757612 – 658PKALK…QYPFH → VELSRHTVSCASQSNMWFLD VLPQKPTCAECNSSPHLSQT DITPPLP in isoform 3. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_052758659 – 1622Missing in isoform 3. 2 PublicationsAdd BLAST964

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047714 mRNA. Translation: AAC13683.1.
AJ867481 mRNA. Translation: CAI30140.1.
AY180104 mRNA. Translation: AAO43093.2.
AK148094 mRNA. Translation: BAE28340.1.
AK148268 mRNA. Translation: BAE28448.1.
AK148275 mRNA. Translation: BAE28453.1.
AK149290 mRNA. Translation: BAE28794.1.
AK164395 mRNA. Translation: BAE37771.1.
AC127565 Genomic DNA. No translation available.
AC139849 Genomic DNA. No translation available.
BC082560 mRNA. Translation: AAH82560.1.
BC085168 mRNA. Translation: AAH85168.1.
CCDSiCCDS21332.2. [Q2TV84-1]
CCDS39975.2. [Q2TV84-3]
RefSeqiNP_001034193.2. NM_001039104.2. [Q2TV84-1]
NP_061222.3. NM_018752.3. [Q2TV84-3]
XP_017177502.1. XM_017322013.1. [Q2TV84-3]
UniGeneiMm.297430.
Mm.38875.

Genome annotation databases

EnsembliENSMUST00000085222; ENSMUSP00000082318; ENSMUSG00000030523. [Q2TV84-1]
ENSMUST00000177102; ENSMUSP00000134947; ENSMUSG00000030523. [Q2TV84-3]
ENSMUST00000205731; ENSMUSP00000145776; ENSMUSG00000030523. [Q2TV84-4]
ENSMUST00000206314; ENSMUSP00000145593; ENSMUSG00000030523. [Q2TV84-2]
ENSMUST00000206706; ENSMUSP00000146265; ENSMUSG00000030523. [Q2TV84-5]
GeneIDi17364.
KEGGimmu:17364.
UCSCiuc009hfp.2. mouse. [Q2TV84-2]
uc009hfr.2. mouse. [Q2TV84-4]
uc009hft.2. mouse. [Q2TV84-5]
uc009hfu.2. mouse. [Q2TV84-3]
uc009hfw.2. mouse. [Q2TV84-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047714 mRNA. Translation: AAC13683.1.
AJ867481 mRNA. Translation: CAI30140.1.
AY180104 mRNA. Translation: AAO43093.2.
AK148094 mRNA. Translation: BAE28340.1.
AK148268 mRNA. Translation: BAE28448.1.
AK148275 mRNA. Translation: BAE28453.1.
AK149290 mRNA. Translation: BAE28794.1.
AK164395 mRNA. Translation: BAE37771.1.
AC127565 Genomic DNA. No translation available.
AC139849 Genomic DNA. No translation available.
BC082560 mRNA. Translation: AAH82560.1.
BC085168 mRNA. Translation: AAH85168.1.
CCDSiCCDS21332.2. [Q2TV84-1]
CCDS39975.2. [Q2TV84-3]
RefSeqiNP_001034193.2. NM_001039104.2. [Q2TV84-1]
NP_061222.3. NM_018752.3. [Q2TV84-3]
XP_017177502.1. XM_017322013.1. [Q2TV84-3]
UniGeneiMm.297430.
Mm.38875.

3D structure databases

ProteinModelPortaliQ2TV84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082318.

PTM databases

iPTMnetiQ2TV84.
PhosphoSitePlusiQ2TV84.

Proteomic databases

PaxDbiQ2TV84.
PRIDEiQ2TV84.

Protocols and materials databases

DNASUi17364.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085222; ENSMUSP00000082318; ENSMUSG00000030523. [Q2TV84-1]
ENSMUST00000177102; ENSMUSP00000134947; ENSMUSG00000030523. [Q2TV84-3]
ENSMUST00000205731; ENSMUSP00000145776; ENSMUSG00000030523. [Q2TV84-4]
ENSMUST00000206314; ENSMUSP00000145593; ENSMUSG00000030523. [Q2TV84-2]
ENSMUST00000206706; ENSMUSP00000146265; ENSMUSG00000030523. [Q2TV84-5]
GeneIDi17364.
KEGGimmu:17364.
UCSCiuc009hfp.2. mouse. [Q2TV84-2]
uc009hfr.2. mouse. [Q2TV84-4]
uc009hft.2. mouse. [Q2TV84-5]
uc009hfu.2. mouse. [Q2TV84-3]
uc009hfw.2. mouse. [Q2TV84-1]

Organism-specific databases

CTDi4308.
MGIiMGI:1330305. Trpm1.

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.
HOVERGENiHBG055663.
InParanoidiQ2TV84.
KOiK04976.
PhylomeDBiQ2TV84.
TreeFamiTF314204.

Enzyme and pathway databases

ReactomeiR-MMU-3295583. TRP channels.

Miscellaneous databases

ChiTaRSiTrpm1. mouse.
PROiQ2TV84.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030523.
ExpressionAtlasiQ2TV84. baseline and differential.
GenevisibleiQ2TV84. MM.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029588. TRPM1.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF13. PTHR13800:SF13. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPM1_MOUSE
AccessioniPrimary (citable) accession number: Q2TV84
Secondary accession number(s): O70334
, Q2WEA6, Q3TPG5, Q3UEW7, Q3UFV6, Q3UFW1, Q3UG69, Q5U4B3, Q640P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.