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Protein

Potassium channel regulatory protein

Gene

Kcnrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel regulatory protein
Short name:
Potassium channel regulator
Alternative name(s):
Protein CLLD4
Gene namesi
Name:Kcnrg
Synonyms:Clld4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2685591. Kcnrg.

Subcellular locationi

  • Endoplasmic reticulum By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002389461 – 264Potassium channel regulatory proteinAdd BLAST264

Proteomic databases

MaxQBiQ2TUM3.
PaxDbiQ2TUM3.
PRIDEiQ2TUM3.

PTM databases

iPTMnetiQ2TUM3.
PhosphoSitePlusiQ2TUM3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046168.
CleanExiMM_KCNRG.

Interactioni

Subunit structurei

Can form homooligomers. Interacts with KCNA1 (via cytoplasmic N-terminal domain) and KCNA4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055327.

Structurei

3D structure databases

ProteinModelPortaliQ2TUM3.
SMRiQ2TUM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 74BTBAdd BLAST70

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000230898.
HOVERGENiHBG079982.
InParanoidiQ2TUM3.
OMAiRYVSIKP.
OrthoDBiEOG091G0EJ2.
PhylomeDBiQ2TUM3.
TreeFamiTF315332.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TUM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGQDLVTLN VGGRIFTTRP STLKQFPASR LAGMLDGRDQ EFKTVDGQIF
60 70 80 90 100
VDRDGALFSF ILDFLRNHEL LLPSDFADHH RLQREALFYE LDSLVDLLSQ
110 120 130 140 150
FLLQSRSAVM EVHFLNQNTQ AFFRVFGSCS KTIEMLSGRI TMFVERPTAL
160 170 180 190 200
TGNRNSPLAL PPQRPSHHDL LFHCGSDGAA ENQAGVRYIS IKPDNRKLAN
210 220 230 240 250
GTNVLGLLVD TLLKEGFHLV STRTPASGEK SECYVFERIT TPQVLGMSKT
260
PKSETTTMPA PSQK
Length:264
Mass (Da):29,417
Last modified:January 24, 2006 - v1
Checksum:i6DDC26A43A999668
GO
Isoform 2 (identifier: Q2TUM3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-191: ISI → FEC
     192-264: Missing.

Show »
Length:191
Mass (Da):21,553
Checksum:i02C6F6D27894DA92
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019023189 – 191ISI → FEC in isoform 2. 3 Publications3
Alternative sequenceiVSP_019024192 – 264Missing in isoform 2. 3 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491736 mRNA. Translation: AAS72551.1.
AY491737 mRNA. Translation: AAS72552.1.
AK053138 mRNA. Translation: BAC35277.1.
BC147091 mRNA. Translation: AAI47092.1.
BC147092 mRNA. Translation: AAI47093.1.
BC171997 mRNA. Translation: AAI71997.1.
CCDSiCCDS27187.1. [Q2TUM3-1]
RefSeqiNP_001034194.1. NM_001039105.3. [Q2TUM3-1]
NP_996857.1. NM_206974.1. [Q2TUM3-3]
UniGeneiMm.224464.

Genome annotation databases

EnsembliENSMUST00000051184; ENSMUSP00000055327; ENSMUSG00000046168. [Q2TUM3-1]
GeneIDi328424.
KEGGimmu:328424.
UCSCiuc007ugd.1. mouse. [Q2TUM3-3]
uc007uge.2. mouse. [Q2TUM3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491736 mRNA. Translation: AAS72551.1.
AY491737 mRNA. Translation: AAS72552.1.
AK053138 mRNA. Translation: BAC35277.1.
BC147091 mRNA. Translation: AAI47092.1.
BC147092 mRNA. Translation: AAI47093.1.
BC171997 mRNA. Translation: AAI71997.1.
CCDSiCCDS27187.1. [Q2TUM3-1]
RefSeqiNP_001034194.1. NM_001039105.3. [Q2TUM3-1]
NP_996857.1. NM_206974.1. [Q2TUM3-3]
UniGeneiMm.224464.

3D structure databases

ProteinModelPortaliQ2TUM3.
SMRiQ2TUM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055327.

PTM databases

iPTMnetiQ2TUM3.
PhosphoSitePlusiQ2TUM3.

Proteomic databases

MaxQBiQ2TUM3.
PaxDbiQ2TUM3.
PRIDEiQ2TUM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051184; ENSMUSP00000055327; ENSMUSG00000046168. [Q2TUM3-1]
GeneIDi328424.
KEGGimmu:328424.
UCSCiuc007ugd.1. mouse. [Q2TUM3-3]
uc007uge.2. mouse. [Q2TUM3-1]

Organism-specific databases

CTDi283518.
MGIiMGI:2685591. Kcnrg.

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000230898.
HOVERGENiHBG079982.
InParanoidiQ2TUM3.
OMAiRYVSIKP.
OrthoDBiEOG091G0EJ2.
PhylomeDBiQ2TUM3.
TreeFamiTF315332.

Miscellaneous databases

PROiPR:Q2TUM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046168.
CleanExiMM_KCNRG.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNRG_MOUSE
AccessioniPrimary (citable) accession number: Q2TUM3
Secondary accession number(s): B2RV87
, B7ZWD9, Q6P8J6, Q8C6V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 24, 2006
Last modified: March 15, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.