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Protein

Potassium channel regulatory protein

Gene

Kcnrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel regulatory protein
Short name:
Potassium channel regulator
Alternative name(s):
Protein CLLD4
Gene namesi
Name:Kcnrg
Synonyms:Clld4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2685591. Kcnrg.

Subcellular locationi

  • Endoplasmic reticulum By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Potassium channel regulatory proteinPRO_0000238946Add
BLAST

Proteomic databases

MaxQBiQ2TUM3.
PaxDbiQ2TUM3.
PRIDEiQ2TUM3.

PTM databases

iPTMnetiQ2TUM3.
PhosphoSiteiQ2TUM3.

Expressioni

Gene expression databases

BgeeiQ2TUM3.
CleanExiMM_KCNRG.

Interactioni

Subunit structurei

Can form homooligomers. Interacts with KCNA1 (via cytoplasmic N-terminal domain) and KCNA4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055327.

Structurei

3D structure databases

ProteinModelPortaliQ2TUM3.
SMRiQ2TUM3. Positions 6-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 7470BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000230898.
HOVERGENiHBG079982.
InParanoidiQ2TUM3.
OMAiRYVSIKP.
OrthoDBiEOG79PJQ2.
PhylomeDBiQ2TUM3.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TUM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGQDLVTLN VGGRIFTTRP STLKQFPASR LAGMLDGRDQ EFKTVDGQIF
60 70 80 90 100
VDRDGALFSF ILDFLRNHEL LLPSDFADHH RLQREALFYE LDSLVDLLSQ
110 120 130 140 150
FLLQSRSAVM EVHFLNQNTQ AFFRVFGSCS KTIEMLSGRI TMFVERPTAL
160 170 180 190 200
TGNRNSPLAL PPQRPSHHDL LFHCGSDGAA ENQAGVRYIS IKPDNRKLAN
210 220 230 240 250
GTNVLGLLVD TLLKEGFHLV STRTPASGEK SECYVFERIT TPQVLGMSKT
260
PKSETTTMPA PSQK
Length:264
Mass (Da):29,417
Last modified:January 24, 2006 - v1
Checksum:i6DDC26A43A999668
GO
Isoform 2 (identifier: Q2TUM3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-191: ISI → FEC
     192-264: Missing.

Show »
Length:191
Mass (Da):21,553
Checksum:i02C6F6D27894DA92
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei189 – 1913ISI → FEC in isoform 2. 3 PublicationsVSP_019023
Alternative sequencei192 – 26473Missing in isoform 2. 3 PublicationsVSP_019024Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491736 mRNA. Translation: AAS72551.1.
AY491737 mRNA. Translation: AAS72552.1.
AK053138 mRNA. Translation: BAC35277.1.
BC147091 mRNA. Translation: AAI47092.1.
BC147092 mRNA. Translation: AAI47093.1.
BC171997 mRNA. Translation: AAI71997.1.
CCDSiCCDS27187.1. [Q2TUM3-1]
RefSeqiNP_001034194.1. NM_001039105.3. [Q2TUM3-1]
NP_996857.1. NM_206974.1. [Q2TUM3-3]
UniGeneiMm.224464.

Genome annotation databases

EnsembliENSMUST00000051184; ENSMUSP00000055327; ENSMUSG00000046168. [Q2TUM3-1]
GeneIDi328424.
KEGGimmu:328424.
UCSCiuc007ugd.1. mouse. [Q2TUM3-3]
uc007uge.2. mouse. [Q2TUM3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491736 mRNA. Translation: AAS72551.1.
AY491737 mRNA. Translation: AAS72552.1.
AK053138 mRNA. Translation: BAC35277.1.
BC147091 mRNA. Translation: AAI47092.1.
BC147092 mRNA. Translation: AAI47093.1.
BC171997 mRNA. Translation: AAI71997.1.
CCDSiCCDS27187.1. [Q2TUM3-1]
RefSeqiNP_001034194.1. NM_001039105.3. [Q2TUM3-1]
NP_996857.1. NM_206974.1. [Q2TUM3-3]
UniGeneiMm.224464.

3D structure databases

ProteinModelPortaliQ2TUM3.
SMRiQ2TUM3. Positions 6-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055327.

PTM databases

iPTMnetiQ2TUM3.
PhosphoSiteiQ2TUM3.

Proteomic databases

MaxQBiQ2TUM3.
PaxDbiQ2TUM3.
PRIDEiQ2TUM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051184; ENSMUSP00000055327; ENSMUSG00000046168. [Q2TUM3-1]
GeneIDi328424.
KEGGimmu:328424.
UCSCiuc007ugd.1. mouse. [Q2TUM3-3]
uc007uge.2. mouse. [Q2TUM3-1]

Organism-specific databases

CTDi283518.
MGIiMGI:2685591. Kcnrg.

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000230898.
HOVERGENiHBG079982.
InParanoidiQ2TUM3.
OMAiRYVSIKP.
OrthoDBiEOG79PJQ2.
PhylomeDBiQ2TUM3.
TreeFamiTF315332.

Miscellaneous databases

PROiQ2TUM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ2TUM3.
CleanExiMM_KCNRG.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a murine CLLD4-related cDNA."
    Skoldberg F., Alimohammadi M., Kampe O.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiKCNRG_MOUSE
AccessioniPrimary (citable) accession number: Q2TUM3
Secondary accession number(s): B2RV87
, B7ZWD9, Q6P8J6, Q8C6V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 24, 2006
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.