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Protein
Submitted name:

Aging-associated protein 1

Gene

AAG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factorImported

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Aging-associated protein 1Imported
Submitted name:
EIF4G2 proteinImported
Submitted name:
Eukaryotic translation initiation factor 4 gamma, 2, isoform CRA_aImported
Gene namesi
Name:AAG1Imported
Synonyms:EIF4G2Imported
ORF Names:hCG_1991788Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27723.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ2TU89.

Expressioni

Gene expression databases

BgeeiENSG00000110321.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini337 – 460124MIInterPro annotationAdd
BLAST
Domaini514 – 698185W2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IPIB. Eukaryota.
ENOG410ZIZB. LUCA.
HOVERGENiHBG052084.
KOiK03260.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TU89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGNIKFIGE LGKLDLIHES ILHKCIKTLL EKKKRVQLKD MGEDLECLCQ
60 70 80 90 100
IMRTVGPRLD HERAKSLMDQ YFARMCSLML SKELPARIRF LLQDTVELRE
110 120 130 140 150
HHWVPRKAFL DNGPKTINQI RQDAVKDLGV FIPAPMAQGM RSDFFLEGPF
160 170 180 190 200
MPPRMKMDRD PLGGLADMFG QMPGSGIGTG PGVIQDRFSP TMGRHRSNQL
210 220 230 240 250
FNGHGGHIMP PTQSQFGEMG GKFMKSQGLS QLYHNQSQGL LSQLQGQSKD
260 270 280 290 300
MPPRFSKKGQ LNADEISLRP AQSFLMNKNQ VPKLQPQITM IPPSAQPPRT
310 320 330 340 350
QTPPLGQTPQ LGLKTNPPLI QEKPAKTSKK PPPSKEELLK LTETVVTEYL
360 370 380 390 400
NSGNANEAVN GVREMRAPKH FLPEMLSKVI ILSLDRSDED KEKASSLISL
410 420 430 440 450
LKQEGIATSD NFMQAFLNVL DQCPKLEVDI PLVKSYLAQF AARAIISELV
460 470 480 490 500
SISELAQPLE SGTHFPLFLL CLQQLAKLQD REWLTELFQQ SKVNMQKMLP
510 520 530 540 550
EIDQNKDRML EILEGKGLSF LFPLLKLEKE LLKQIKLDPS PQTIYKWIKD
560 570 580 590 600
NISPKLHVDK GFVNILMTSF LQYISSEVNP PSDETDSSSA PSKEQLEQEK
610 620 630 640 650
QLLLSFKPVM QKFLHDHVDL QVSALYALQV HCYNSNFPKG MLLRFFVHFY
660 670 680 690 700
DMEIIEEEAF LAWKEDITQE FPGKGKALFQ VNQWLTWLET AEEEESEEEA

D
Length:701
Mass (Da):79,614
Last modified:January 24, 2006 - v1
Checksum:i08C279495DD0FC21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065276 mRNA. Translation: AAH65276.1.
AY513274 mRNA. Translation: AAT08027.1.
CH471064 Genomic DNA. Translation: EAW68552.1.
RefSeqiNP_001166176.1. NM_001172705.1.
UniGeneiHs.183684.

Genome annotation databases

GeneIDi1982.
KEGGihsa:1982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065276 mRNA. Translation: AAH65276.1.
AY513274 mRNA. Translation: AAT08027.1.
CH471064 Genomic DNA. Translation: EAW68552.1.
RefSeqiNP_001166176.1. NM_001172705.1.
UniGeneiHs.183684.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340281.

Proteomic databases

PeptideAtlasiQ2TU89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1982.
KEGGihsa:1982.

Organism-specific databases

CTDi1982.
PharmGKBiPA27723.

Phylogenomic databases

eggNOGiENOG410IPIB. Eukaryota.
ENOG410ZIZB. LUCA.
HOVERGENiHBG052084.
KOiK03260.

Miscellaneous databases

ChiTaRSiEIF4G2. human.
GenomeRNAii1982.

Gene expression databases

BgeeiENSG00000110321.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ2TU89_HUMAN
AccessioniPrimary (citable) accession number: Q2TU89
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.