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Protein

Aspartate aminotransferase

Gene

GIG18

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.UniRule annotation

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferaseUniRule annotation (EC:2.6.1.1UniRule annotation)
Gene namesi
Name:GIG18Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Chemistry databases

DrugBankiDB00142. Glutamic Acid.
DB00128. L-Aspartic Acid.
DB00114. Pyridoxal Phosphate.

PTM / Processingi

Proteomic databases

PaxDbiQ2TU84.
PeptideAtlasiQ2TU84.
PRIDEiQ2TU84.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2TU84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 405Aminotran_1_2InterPro annotationAdd BLAST374

Phylogenomic databases

eggNOGiKOG1411. Eukaryota.
COG1448. LUCA.
HOVERGENiHBG000951.

Family and domain databases

Gene3Di3.90.1150.10. 2 hits.
InterProiView protein in InterPro
IPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00105. AA_TRANSFER_CLASS_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2TU84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV
60 70 80 90 100
LPVVKKVEQK IANDNSLNHE YLPILGLAEF RSCASRLALE DDSPALKEKR
110 120 130 140 150
VGGVQSLGGT GALRIGADFL ARWYNGTNNK NTPVYVSSPT WENHNAVFSA
160 170 180 190 200
AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN APEFSIVVLH ACAHNPTGID
210 220 230 240 250
PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA IRYFVSEGFE
260 270 280 290 300
FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP
310 320 330 340 350
AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT
360 370 380 390 400
WNHITDQIGM FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY
410
VATSIHEAVT KIQ
Length:413
Mass (Da):46,320
Last modified:January 24, 2006 - v1
Checksum:iCC00898206D2B2CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513279 mRNA. Translation: AAT08032.1.
UniGeneiHs.500756.

Similar proteinsi

Entry informationi

Entry nameiQ2TU84_HUMAN
AccessioniPrimary (citable) accession number: Q2TU84
Entry historyiIntegrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 27, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.