Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hydroxysteroid dehydrogenase-like protein 2

Gene

Hsdl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has apparently no steroid dehydrogenase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42NADPBy similarity1
Binding sitei74NADPBy similarity1
Active sitei168Proton acceptorSequence analysis1
Binding sitei172NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 23NADPBy similarity7

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid dehydrogenase-like protein 2 (EC:1.-.-.-)
Gene namesi
Name:Hsdl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919729. Hsdl2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: Ensembl
  • mitochondrion Source: MGI
  • peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198891 – 490Hydroxysteroid dehydrogenase-like protein 2Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-acetyllysineCombined sources1
Modified residuei390N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ2TPA8.
MaxQBiQ2TPA8.
PaxDbiQ2TPA8.
PeptideAtlasiQ2TPA8.
PRIDEiQ2TPA8.

2D gel databases

REPRODUCTION-2DPAGEQ2TPA8.

PTM databases

iPTMnetiQ2TPA8.
PhosphoSitePlusiQ2TPA8.
SwissPalmiQ2TPA8.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

Up-regulated by cholesterol-rich food.1 Publication

Gene expression databases

BgeeiENSMUSG00000028383.
CleanExiMM_HSDL2.
ExpressionAtlasiQ2TPA8. baseline and differential.
GenevisibleiQ2TPA8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ2TPA8. 2 interactors.
MINTiMINT-1860458.
STRINGi10090.ENSMUSP00000030078.

Structurei

3D structure databases

ProteinModelPortaliQ2TPA8.
SMRiQ2TPA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini380 – 487SCP2Add BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi300 – 375Gln/Glu/Pro-richAdd BLAST76

Sequence similaritiesi

Contains 1 SCP2 domain.Curated

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
KOG4170. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00730000111071.
HOVERGENiHBG107982.
InParanoidiQ2TPA8.
OMAiEPKQFTG.
OrthoDBiEOG091G0EVM.
PhylomeDBiQ2TPA8.
TreeFamiTF101523.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF55718. SSF55718. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2TPA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPNTGKLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTTQKHPKL
60 70 80 90 100
LGTIYTAAEE IEAAGGTALP CVVDVRDEQQ INSAVEKAVE KFGGIDILVN
110 120 130 140 150
NASAISLTNT LDTPTKRVDL MMNVNTRGTY LTSKACIPFL KKSKVGHILN
160 170 180 190 200
LSPPLNLNPL WFKQHCAYTI AKYGMSMCVL GMAEEFRGEI AVNALWPRTA
210 220 230 240 250
IHTAAMDMLG GSGVENQCRK VDIIADAAYS IFKRPKSFTG NFIIDENILK
260 270 280 290 300
EEGIKNFDVY AIAPGHPLLP DFFLDEHPDA VMEEKESNDS VPEVKEEKLQ
310 320 330 340 350
LQEESQLQKQ PQLQEQPQLQ EKPQLQEKPQ LQEQPQLQEK PQLQEQPQQR
360 370 380 390 400
EQPQLQQQPR PRQQPQPFVQ SMLPQKPHFG AVEETFRIVK DSLSDEVVRA
410 420 430 440 450
TQAVYQFELS GEDGGTWFLD LKSKGGKVGH GEPSDRADVV MSMATDDFVK
460 470 480 490
MFSGKLKPTM AFMSGKLKIK GNIALAIKLE KLMTQMNSRL
Length:490
Mass (Da):54,208
Last modified:January 24, 2006 - v1
Checksum:i700958CDA46905DB
GO

Sequence cautioni

The sequence BAC39563 differs from that shown. Reason: Frameshift at position 336.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307L → V in BAE23126 (PubMed:16141072).Curated1
Sequence conflicti328K → KPQLQEKPQLQEQ in BAE26313 (PubMed:16141072).Curated1
Sequence conflicti333E → EQPQLQQ in AAH02211 (PubMed:15489334).Curated1
Sequence conflicti334Q → K in BAE26313 (PubMed:16141072).Curated1
Sequence conflicti353P → Q in BAE26313 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725196 mRNA. Translation: AAU11505.1.
AK085899 mRNA. Translation: BAC39563.1. Frameshift.
AK136773 mRNA. Translation: BAE23126.1.
AK145230 mRNA. Translation: BAE26313.1.
AL806512, BX005031 Genomic DNA. Translation: CAM21909.1.
BX005031, AL806512 Genomic DNA. Translation: CAM26657.1.
BC002211 mRNA. Translation: AAH02211.1.
CCDSiCCDS38772.1.
RefSeqiNP_077217.2. NM_024255.3.
UniGeneiMm.272905.

Genome annotation databases

EnsembliENSMUST00000030078; ENSMUSP00000030078; ENSMUSG00000028383.
GeneIDi72479.
KEGGimmu:72479.
UCSCiuc008szy.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725196 mRNA. Translation: AAU11505.1.
AK085899 mRNA. Translation: BAC39563.1. Frameshift.
AK136773 mRNA. Translation: BAE23126.1.
AK145230 mRNA. Translation: BAE26313.1.
AL806512, BX005031 Genomic DNA. Translation: CAM21909.1.
BX005031, AL806512 Genomic DNA. Translation: CAM26657.1.
BC002211 mRNA. Translation: AAH02211.1.
CCDSiCCDS38772.1.
RefSeqiNP_077217.2. NM_024255.3.
UniGeneiMm.272905.

3D structure databases

ProteinModelPortaliQ2TPA8.
SMRiQ2TPA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2TPA8. 2 interactors.
MINTiMINT-1860458.
STRINGi10090.ENSMUSP00000030078.

PTM databases

iPTMnetiQ2TPA8.
PhosphoSitePlusiQ2TPA8.
SwissPalmiQ2TPA8.

2D gel databases

REPRODUCTION-2DPAGEQ2TPA8.

Proteomic databases

EPDiQ2TPA8.
MaxQBiQ2TPA8.
PaxDbiQ2TPA8.
PeptideAtlasiQ2TPA8.
PRIDEiQ2TPA8.

Protocols and materials databases

DNASUi72479.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030078; ENSMUSP00000030078; ENSMUSG00000028383.
GeneIDi72479.
KEGGimmu:72479.
UCSCiuc008szy.3. mouse.

Organism-specific databases

CTDi84263.
MGIiMGI:1919729. Hsdl2.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
KOG4170. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00730000111071.
HOVERGENiHBG107982.
InParanoidiQ2TPA8.
OMAiEPKQFTG.
OrthoDBiEOG091G0EVM.
PhylomeDBiQ2TPA8.
TreeFamiTF101523.

Miscellaneous databases

PROiQ2TPA8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028383.
CleanExiMM_HSDL2.
ExpressionAtlasiQ2TPA8. baseline and differential.
GenevisibleiQ2TPA8. MM.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF55718. SSF55718. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSDL2_MOUSE
AccessioniPrimary (citable) accession number: Q2TPA8
Secondary accession number(s): Q3ULY5
, Q3UVZ3, Q8C3H3, Q99LV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.