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Protein

Caveolin

Gene

CAV1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CaveolinUniRule annotation
Gene namesi
Name:CAV1Imported
ORF Names:hCG_39088Imported, tcag7.24Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000105974.11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 129HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Golgi apparatusUniRule annotationSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26107

PTM / Processingi

Proteomic databases

MaxQBiQ2TNI1
PRIDEiQ2TNI1

Expressioni

Gene expression databases

BgeeiENSG00000105974
ExpressionAtlasiQ2TNI1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ2TNI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IV7A Eukaryota
ENOG4111HJR LUCA
HOVERGENiHBG003422
KOiK06278
OMAiIYVHTFC
OrthoDBiEOG091G0M1R

Family and domain databases

InterProiView protein in InterPro
IPR015504 CAV-1
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF18 PTHR10844:SF18, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q2TNI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTVCDPLF EAVGKIFSNV RINLQKEI
Length:178
Mass (Da):20,472
Last modified:January 24, 2006 - v1
Checksum:i2424DE9B5E6521D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei178Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762103 mRNA Translation: AAX07830.1
AK290871 mRNA Translation: BAF83560.1
AB451284 mRNA Translation: BAG70098.1
AB451416 mRNA Translation: BAG70230.1
CH236947 Genomic DNA Translation: EAL24360.1
CH471070 Genomic DNA Translation: EAW83504.1
RefSeqiNP_001166366.1, NM_001172895.1
NP_001166367.1, NM_001172896.1
NP_001166368.1, NM_001172897.1
NP_001744.2, NM_001753.4
UniGeneiHs.74034

Genome annotation databases

GeneIDi857
KEGGihsa:857
UCSCiuc003vif.3 human

Similar proteinsi

Entry informationi

Entry nameiQ2TNI1_HUMAN
AccessioniPrimary (citable) accession number: Q2TNI1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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