Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caveolin

Gene

CAV1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CaveolinUniRule annotation
Gene namesi
Name:CAV1Imported
ORF Names:hCG_39088Imported, tcag7.24Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Golgi apparatus membrane UniRule annotation; Peripheral membrane protein UniRule annotation
  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation
  • Membranecaveola UniRule annotation; Peripheral membrane protein UniRule annotation
  • Membranecaveola SAAS annotation; Peripheral membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 129HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Golgi apparatusUniRule annotationSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26107.

PTM / Processingi

Proteomic databases

MaxQBiQ2TNI1.

Expressioni

Gene expression databases

BgeeiENSG00000105974.
ExpressionAtlasiQ2TNI1. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ2TNI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IV7A. Eukaryota.
ENOG4111HJR. LUCA.
HOVERGENiHBG003422.
KOiK06278.
OMAiIYVHTFC.
OrthoDBiEOG091G0M1R.

Family and domain databases

InterProiView protein in InterPro
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
PANTHERiPTHR10844. PTHR10844. 1 hit.
PfamiView protein in Pfam
PF01146. Caveolin. 1 hit.
PROSITEiView protein in PROSITE
PS01210. CAVEOLIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2TNI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTVCDPLF EAVGKIFSNV RINLQKEI
Length:178
Mass (Da):20,472
Last modified:January 24, 2006 - v1
Checksum:i2424DE9B5E6521D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei178Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762103 mRNA. Translation: AAX07830.1.
AK290871 mRNA. Translation: BAF83560.1.
AB451284 mRNA. Translation: BAG70098.1.
AB451416 mRNA. Translation: BAG70230.1.
CH236947 Genomic DNA. Translation: EAL24360.1.
CH471070 Genomic DNA. Translation: EAW83504.1.
RefSeqiNP_001166366.1. NM_001172895.1.
NP_001166367.1. NM_001172896.1.
NP_001166368.1. NM_001172897.1.
NP_001744.2. NM_001753.4.
UniGeneiHs.74034.

Genome annotation databases

GeneIDi857.
KEGGihsa:857.
UCSCiuc003vif.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ2TNI1_HUMAN
AccessioniPrimary (citable) accession number: Q2TNI1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.