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Protein

E3 ubiquitin-protein ligase UBR4

Gene

Ubr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1657 – 173074UBR-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Calmodulin-binding, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR4 (EC:6.3.2.-)
Alternative name(s):
N-recognin-4
Zinc finger UBR1-type protein 1
Gene namesi
Name:Ubr4
Synonyms:Rbaf600, Zubr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1563121. Ubr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 51945194E3 ubiquitin-protein ligase UBR4PRO_0000286863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781PhosphoserineCombined sources
Modified residuei181 – 1811PhosphoserineCombined sources
Modified residuei212 – 2121PhosphoserineBy similarity
Modified residuei370 – 3701PhosphotyrosineBy similarity
Modified residuei1085 – 10851N6-acetyllysineBy similarity
Modified residuei1403 – 14031PhosphoserineCombined sources
Modified residuei1648 – 16481PhosphoserineBy similarity
Modified residuei1653 – 16531PhosphoserineBy similarity
Modified residuei1755 – 17551PhosphoserineCombined sources
Modified residuei2715 – 27151PhosphothreonineBy similarity
Modified residuei2719 – 27191PhosphoserineCombined sources
Modified residuei2722 – 27221PhosphoserineCombined sources
Modified residuei2724 – 27241PhosphothreonineCombined sources
Modified residuei2956 – 29561PhosphothreonineBy similarity
Modified residuei2964 – 29641PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2TL32.
PRIDEiQ2TL32.

PTM databases

iPTMnetiQ2TL32.
PhosphoSiteiQ2TL32.

Interactioni

Subunit structurei

Interacts with RB1 and calmodulin.By similarity

Protein-protein interaction databases

BioGridi260504. 2 interactions.
IntActiQ2TL32. 1 interaction.
STRINGi10116.ENSRNOP00000032156.

Structurei

3D structure databases

ProteinModelPortaliQ2TL32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 157Poly-Ala
Compositional biasi608 – 62619Pro-richAdd
BLAST
Compositional biasi811 – 8166Poly-Leu
Compositional biasi2728 – 273811Poly-AspAdd
BLAST
Compositional biasi2831 – 292898Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the UBR4 family.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1657 – 173074UBR-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1776. Eukaryota.
ENOG410XPP8. LUCA.
HOGENOMiHOG000115603.
HOVERGENiHBG058328.
InParanoidiQ2TL32.
KOiK10691.
PhylomeDBiQ2TL32.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR025704. E3_Ub_ligase_UBR4.
IPR017986. WD40_repeat_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF13764. E3_UbLigase_R4. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TL32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP
60 70 80 90 100
QLVASVIESE SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV
110 120 130 140 150
AAACKVLIEF SLLRLENPDE ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT
160 170 180 190 200
FTAMMKSAKL PQTVKTLSDV EDQKELASPV SPELRQKEVQ MNFLNQLTSV
210 220 230 240 250
FNPRTVPSPP ISPQALVEGE NDEQSSTEQA SAVKTKNVFI AQNVASLQEL
260 270 280 290 300
GGSEKLLRVC LNLPYFLRYI NRFQDAVVAN SFFIMPATVA DATAVRNGFH
310 320 330 340 350
SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL
360 370 380 390 400
HVGSAQQVRT GSTSSKEEDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG
410 420 430 440 450
EHFQNFQLLG AWCLLNSLFL ILHLSPTALA DKGKEKDPLA ALRVRDILSR
460 470 480 490 500
TKEGVGSPKL GPGKGHQGFG VLSVILANHA IKLLTSLFQD LQVEALHKGW
510 520 530 540 550
ETDGPPAVLS IMAQSTSTQR VQRLIDSVPL TNLLLTLLST SYRKACVLQR
560 570 580 590 600
QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS
610 620 630 640 650
PSKEKAAPPP PPPPPPLESS PRVKSPSKQA SGEKGNILAS RKDPELFLGL
660 670 680 690 700
ASNILNFITS SMLNSRNNFI RNYLSVSLSE QHMATLASII KEVDKDGLKG
710 720 730 740 750
SSDEDFAAAL YHFNHSLVTS DLQSPNLQNT LLQQLGVAPL SSGPWPLYIH
760 770 780 790 800
PQGLSVLSRL LLIWQHKAGA QGDPDVPECL KVWDRFLTTM KQSALQGVVP
810 820 830 840 850
SETEDLNIEH LQLLLLIFHS FSEKGRRAIL TTLVQSIQEL SVNMEVQMRS
860 870 880 890 900
APLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSSS
910 920 930 940 950
SSRRANIPLY HGFKEVEENW SKHFSSDAAP QPRFYCVLST EASEEDLNRL
960 970 980 990 1000
DSEACEVLFS KLVKYDELYS SLTALLAAGS QLDTVKRKEN KNMTALEACA
1010 1020 1030 1040 1050
LQYYFLILWR ILGILPPSKT YMNQLAMNSP EMSECDILHT LRWSSRLRIS
1060 1070 1080 1090 1100
SYVSWIKDHL IRQGMRPEHA GSLVELAASK CSSVKYDVEI VEEYFARQIS
1110 1120 1130 1140 1150
SFCSIDCTTV LQLHEIPSLQ SIYTLDAAVS KVQVSLDEHF SKMAAETDPH
1160 1170 1180 1190 1200
KSSEITKNLL PATLQLIDTY ASFTRAYLLQ NLNEEGSTEK PSQEKLHGFA
1210 1220 1230 1240 1250
AVLAIGSSRC KANTLGPTLV QNLPSSVQSV CESWNNINTN EFPNIGSWRN
1260 1270 1280 1290 1300
AFANDTIPSE SYISAVQAAH LGTLCGQSLP LAASLKHALL SLVRLTGDLI
1310 1320 1330 1340 1350
VWSDEMNPAQ VIRALLPLLL ESSTESAAEI SSNSLERILG PAESDEFLAR
1360 1370 1380 1390 1400
VYEKLITGCY NILANHADPS SGLDESVLEE CLQYLEKQLE SSQARKAMEE
1410 1420 1430 1440 1450
FFSDGGELVQ IMMATANEDL SAKFCNRVLK FFTKLFQLTE KSPNPSLLHL
1460 1470 1480 1490 1500
CGSLAQLACV EPVRLQAWLT RMTTSPPKDS DQLEVIQENR QLLQLLTTYI
1510 1520 1530 1540 1550
VRENSQVGEG VCAVLLGTLT PMATDMLANG DGTGFPELMV VMATLASAGQ
1560 1570 1580 1590 1600
GAGHLQLHNA AVDWLGRCKK YLSQKNVVEK LNANVMHGKH VMVLECTCHI
1610 1620 1630 1640 1650
MSYLADVTNA LSQSNGQGPS HLSVDGEERA IEVDSDWVEE LAVEEEDSQA
1660 1670 1680 1690 1700
EDSDEDSLCN KLCTFTITQK EFMNQHWYHC HTCKMVDGVG VCTVCAKVCH
1710 1720 1730 1740 1750
KDHEISYAKY GSFFCDCGAK EDGSCLALVK RTPSSGMSST MKESAFQSEP
1760 1770 1780 1790 1800
RVSESLVRHA STSPADKAKV TISDGKVADE EKPKKSSLCR TVEGCREELQ
1810 1820 1830 1840 1850
NQANFSFAPL VLDMLNFLMD AIQTNFQQAS AVGSSSRAQQ ALSELHTVDK
1860 1870 1880 1890 1900
VVEMTDQLMV PTLGSQEGAF ENVRMNYSGD QGQTIRQLIS AHVLRRVAMC
1910 1920 1930 1940 1950
VLSSPHGRRQ HLAVSHEKGK ITVLQLSALL KQADSSKRKL TLTRLASAPV
1960 1970 1980 1990 2000
PFTVLSLTGN PCKEDYLAVC GLKDCHVLTF SSSGSVSDHL VLHPQLATGN
2010 2020 2030 2040 2050
FIIKAVWLPG SQTELAIVTA DFVKIYDLSV DALSPTFYFL LPSSKIRDVT
2060 2070 2080 2090 2100
FLFNEEGKNI IVIMSSAGYM YTQLMEEASS AQQGPFYVTN VLEINHEDLK
2110 2120 2130 2140 2150
DSNSQVAGGG VSVYYSHVLQ MLFFSYSQGK SFAATVSRST LEVLQLFPIN
2160 2170 2180 2190 2200
IKSSNGGSKT SPALCQWSEV MNHPGLVCCV QQTTGVPLVV MVKPDTFLIQ
2210 2220 2230 2240 2250
EIKTLPAKAK IQDMVAIRHT ACNEQQRTTM ILLCEDGSLR IYMANVENTS
2260 2270 2280 2290 2300
YWLQPSLQPS SVISIMKPVR KRKTATITAR TSSQVTFPID FFEHNQQLTD
2310 2320 2330 2340 2350
VEFGGNDLLQ VYNAQQIKHR LNSTGMYVAN TKPGGFTMEI SNNSSTMVMT
2360 2370 2380 2390 2400
GMRIQIGTQA IERAPSYIEI FGRTMQLNLS RSRWFDFPFT REEALQADRK
2410 2420 2430 2440 2450
LNLFIGASVD PAGVTMIDAV KIYGKTKEQF GWPDEPPEDF PSASVSSVCP
2460 2470 2480 2490 2500
PNLNQSNSTG DSDSAAPATT SGTVLERLVV SSLEALESCF AVGPIIEKER
2510 2520 2530 2540 2550
NKHAAQELAT LLLSLPAPAS VQQQSKSLLA SLHSSRSAYH SHKDQALLSK
2560 2570 2580 2590 2600
AVQCLNTSSK EGKDLDPEVF QRLVITARSI AVTRPNNLVH FTESKLPQME
2610 2620 2630 2640 2650
TEGAEEGKEP QKQVEGDGCS FITQLVNHFW KLHASKPKNA FLAPACLPGL
2660 2670 2680 2690 2700
THIEATVNAL VDIIHGYCTC ELDCINTASK IYMQMLLCPD PAVSFSCKQA
2710 2720 2730 2740 2750
LIRVLRPRNK RRHVTLPSSP RSNTPMGDKD DDDDDDADEK MQSSGIPDGG
2760 2770 2780 2790 2800
HIRQESQEQS EVDHGDFEMV SESMVLETAE NVNNGNPSPL EALLAGAEGF
2810 2820 2830 2840 2850
PPMLDIPPDA DDETMVELAI ALSLQQDQQG SSSSALGLQS LGLSGQAPSS
2860 2870 2880 2890 2900
SSLDAGTLSD TTASGVCACN SSVTLSAPAS DDEGSTAATD GSTLRTSPAD
2910 2920 2930 2940 2950
HGGSVGSESG GSAVDSVAGE HSVSGRSSAY GDATAEGHPA GPGSVSSSTG
2960 2970 2980 2990 3000
AISTTTGHQE GDGSEGEGEG EAEGDVHTSN RLHMVRLMLL ERLLQTLPQL
3010 3020 3030 3040 3050
RNVGGVRAIP YMQVILMLTT DLDGEDEKDK GALDNLLAQL IAELGMDKKD
3060 3070 3080 3090 3100
VSKKNERSAL NEVHLVVMRL LSVFMSRTKS GSKSSICESS SLISSATAAA
3110 3120 3130 3140 3150
LLSSGAVDYC LHVLKSLLEY WKGQQSEEEP VTTSQLLKPH TTSSPPDMSP
3160 3170 3180 3190 3200
FFLRQYVKGH AADVFEAYTQ LLTEMVLRLP YQIKKIADTS SRIPPPVFDH
3210 3220 3230 3240 3250
SWFYFLSEYL MIQQTPFVRR QVRKLLLFIC GSKEKYRQLR DLHTLDSHVR
3260 3270 3280 3290 3300
GIKKLLEEQG IFLRASVVTA SSGSALQYDT LISLMEHLKA CAEIAAQRTI
3310 3320 3330 3340 3350
NWQKFCIKDD SVLYFLLQVS FLVDEGVSPV LLQLLSCALC GSKVLAALAA
3360 3370 3380 3390 3400
STGSSSVASS APPAASSGQT TTQSKSSTKK SKKEKKEKEK EGESSGSQED
3410 3420 3430 3440 3450
QLCTALVNQL NRFADKETLI QFLRCFLLES NSSSVRWQAH CLTLHIYRNS
3460 3470 3480 3490 3500
NKAQQELLLD LMWSIWPELP AYGRKAAQFV DLLGYFSLKT AQTEKKLKEY
3510 3520 3530 3540 3550
SQKAVEILRT QNHILTNHPN SNIYNTLSGL VEFDGYYLES DPCLVCNNPE
3560 3570 3580 3590 3600
VPFCYIKLSS IKVDTRYTTT QQVVKLIGSH TISKVTVKIG DLKRTKMVRT
3610 3620 3630 3640 3650
INLYYNNRTV QAIVELKNKP ARWHKAKKVQ LTPGQTEVKI DLPLPIVASN
3660 3670 3680 3690 3700
LMIEFADFYE NYQASTETLQ CPRCSASVPA NPGVCGNCGE NVYQCHKCRS
3710 3720 3730 3740 3750
INYDEKDPFL CNACGFCKYA RFDFMLYAKP CCAVDPIENE EDRKKAVSNI
3760 3770 3780 3790 3800
NTLLDKADRV YHQLMGHRPQ LENLLCKVNE AAPEKPQEDS GTAGGISSTS
3810 3820 3830 3840 3850
ASVNRYILQL AQEYCGDCKN SFDELSKIIQ KVFASRKELL EYDLQQREAA
3860 3870 3880 3890 3900
TKSSRTSVQP TFTASQYRAL SVLGCGHTSS TKCYGCASAV TEHCITLLRA
3910 3920 3930 3940 3950
LATNPALRHI LVSQGLIREL FDYNLRRGAA AIREEVRQLM CLLTRDNPEA
3960 3970 3980 3990 4000
TQQMNDLIIG KVSTALKGHW ANPDLASSLQ YEMLLLTDSI SKEDSCWELR
4010 4020 4030 4040 4050
LRCALSLFLM AVNIKTPVVV ENITLMCLRI LQKLIKPPAP TSKKNKDVPV
4060 4070 4080 4090 4100
EALTTVKPYC NEIHAQAQLW LKRDPKASYE AWKKCLPIRG VDGNGKSPSK
4110 4120 4130 4140 4150
SELHRLYLTE KYVWRWKQFL SRRGKRTTPL DLKLGHNNWL RQVLFTPATQ
4160 4170 4180 4190 4200
AARQAACTIV EALASVPSRK QQVLDLLTSY LDELSVAGEC AAEYLALYQK
4210 4220 4230 4240 4250
LIASCHWKVY LAARGVLPYV GNLITKEIAR LLALEEATLS TDLQQGYALK
4260 4270 4280 4290 4300
SLTGLLSSFV EVESIKRHFK SRLVGTVLNG YLCLRKLVLQ RTKLIDETQD
4310 4320 4330 4340 4350
MLLEMLEDMT TGTESETKAF MAVCIETAKR YNLDDYRTPV FIFERLCSII
4360 4370 4380 4390 4400
YPEENEVTEF FVTLEKDPQQ EDFLQGRMPG NPYSSNEPGI GPLMRDIKNK
4410 4420 4430 4440 4450
ICQDCDLVAL LEDDSGMELL VNNKIISLDL PVAEVYKKVW CTTNEGEPMR
4460 4470 4480 4490 4500
IVYRMRGLLG DATEEFIESL DSTTDEEEDE EEVYRMAGVM AQCGGLQCML
4510 4520 4530 4540 4550
NRLAGVKDFK QGRHLLTVLL KLFSYCVKVK VNRQQLVKLE MNTLNVMLGT
4560 4570 4580 4590 4600
LNLALVAEQE SKDSGGAAVA EQVLSIMEII LDESNAEPLS EDKGNLLLTG
4610 4620 4630 4640 4650
DKDQLVMLLD QINSTFVRSN PSVLQGLLRI IPYLSFGEVE KMQILVERFK
4660 4670 4680 4690 4700
PYCSFDKYDE DHSGDDKVFL DCFCKIAAGI KNNSNGHQLK DLILQKGITQ
4710 4720 4730 4740 4750
SALDYMKKHI PSAKNLDADI WKKFLSRPAL PFILRLLRGL AMQHPATQVL
4760 4770 4780 4790 4800
IGTDSITSLH KLEQVSSDEG IGTLAENLLE ALREHPDVNK KIDAARRETR
4810 4820 4830 4840 4850
AEKKRMAMAM RQKALGTLGM TTNEKGQVVT KTALLKQMEE LIEEPGLTCC
4860 4870 4880 4890 4900
ICREGYKFQP TKVLGIYTFT KRVALEEMEN KPRKQQGYST VSHFNIVHYD
4910 4920 4930 4940 4950
CHLAAVRLAR GREEWESAAL QNANTKCNGL LPVWGPHVPE SAFATCLARH
4960 4970 4980 4990 5000
NTYLQECTGQ REPTYQLNIH DIKLLFLRFA MEQSFSADTG GGGRESNIHL
5010 5020 5030 5040 5050
IPYIIHTVLY VLNTTRATSR EEKNLQGFLE QPREKWTESA FDVDGPHYFT
5060 5070 5080 5090 5100
ILALHVLPPE QWKATRVEIL RRLLVASHAR AVAPGGATRL TDKAVKDYSA
5110 5120 5130 5140 5150
YRSSLLFWAL VDLIYNMFKK VPTSNTEGGW SCSLAEYIRH NDMPIYEAAD
5160 5170 5180 5190
KALKTFQEEF MPVETFSEFL DAAGLLSEIT DPESFLKDLL NSVP
Length:5,194
Mass (Da):573,792
Last modified:May 15, 2007 - v2
Checksum:i1F7C929C147369E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY850927 mRNA. Translation: AAX45146.1.
BC091421 mRNA. Translation: AAH91421.1.
RefSeqiNP_001034115.1. NM_001039026.1.
UniGeneiRn.37755.

Genome annotation databases

GeneIDi313658.
KEGGirno:313658.
UCSCiRGD:1563121. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY850927 mRNA. Translation: AAX45146.1.
BC091421 mRNA. Translation: AAH91421.1.
RefSeqiNP_001034115.1. NM_001039026.1.
UniGeneiRn.37755.

3D structure databases

ProteinModelPortaliQ2TL32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi260504. 2 interactions.
IntActiQ2TL32. 1 interaction.
STRINGi10116.ENSRNOP00000032156.

PTM databases

iPTMnetiQ2TL32.
PhosphoSiteiQ2TL32.

Proteomic databases

PaxDbiQ2TL32.
PRIDEiQ2TL32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi313658.
KEGGirno:313658.
UCSCiRGD:1563121. rat.

Organism-specific databases

CTDi23352.
RGDi1563121. Ubr4.

Phylogenomic databases

eggNOGiKOG1776. Eukaryota.
ENOG410XPP8. LUCA.
HOGENOMiHOG000115603.
HOVERGENiHBG058328.
InParanoidiQ2TL32.
KOiK10691.
PhylomeDBiQ2TL32.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi666613.
PROiQ2TL32.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR025704. E3_Ub_ligase_UBR4.
IPR017986. WD40_repeat_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF13764. E3_UbLigase_R4. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and characterization of a zinc-finger containing gene (ZUBR1) induced by bright cyclic light."
    Zhang Q., Anderson R.E.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4841-5194.
    Tissue: Spleen.
  3. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1403, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-181; SER-1755; SER-2719; SER-2722 AND THR-2724, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBR4_RAT
AccessioniPrimary (citable) accession number: Q2TL32
Secondary accession number(s): Q5BJM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 11, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.