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Q2TJB8

- Q2TJB8_TRYCR

UniProt

Q2TJB8 - Q2TJB8_TRYCR

Protein
Submitted name:

Dehydrogenase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611FMN; via amide nitrogen
    Binding sitei103 – 1031FMNImported
    Binding sitei195 – 1951FMNImported
    Binding sitei249 – 2491FMNImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 283FMNImported
    Nucleotide bindingi313 – 3153FMNImported
    Nucleotide bindingi336 – 3372FMNImported

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. oxidoreductase activity Source: InterPro

    Keywords - Ligandi

    Flavoprotein, FMNImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    DehydrogenaseImported
    OrganismiTrypanosoma cruziImported
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E2BX-ray1.27A1-379[»]
    4E2DX-ray2.00A/B/C/D1-379[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view]
    PfamiPF00724. Oxidored_FMN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2TJB8-1 [UniParc]FASTAAdd to Basket

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    MATFPELLRP LKLGRYTLRN RIIMAPLTRC QATEDGHVPR TESMLKYYED    50
    RASAGLIIAE ATMVQPNYTG FLTEPGIYSD AQIEEWRKIV DAVHKKGGLI 100
    FLQLIHAGRA GIPEKILQQP KSDQDPLAGR LLAASAIPIK DHRIPAYFAA 150
    SGEKETYGVP EELTDDEVRN GIIPLFVEGA KNAIFKAGFD GVEIHGANGY 200
    LLDAFFRESS NKRQSGPYAG TTIDTRCQLI YDVTKSVCDA VGSDRVGLRI 250
    SPLNGVHGMI DSNPEALTKH LCKKIEPLSL AYLHYLRGDM VNQQIGDVVA 300
    WVRGSYSGVK ISNLRYDFEE ADQQIREGKV DAVAFGAKFI ANPDLVERAQ 350
    HDWPLNEPRP ETYYTRTAVG YNDYPTYNK 379
    Length:379
    Mass (Da):42,222
    Last modified:January 24, 2006 - v1
    Checksum:i61EB1116CB1EE974
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY863012 Genomic DNA. Translation: AAX54854.1.
    AY863013 Genomic DNA. Translation: AAX54855.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY863012 Genomic DNA. Translation: AAX54854.1 .
    AY863013 Genomic DNA. Translation: AAX54855.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E2B X-ray 1.27 A 1-379 [» ]
    4E2D X-ray 2.00 A/B/C/D 1-379 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view ]
    Pfami PF00724. Oxidored_FMN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi."
      Murta S.M., Krieger M.A., Montenegro L.R., Campos F.F., Probst C.M., Avila A.R., Muto N.H., de Oliveira R.C., Nunes L.R., Nirde P., Bruna-Romero O., Goldenberg S., Romanha A.J.
      Mol. Biochem. Parasitol. 146:151-162(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 17LEImported and 17wtImported.
    2. "High resolution crystal structure and in solution studies of the old yellow enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
      Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
      Submitted (MAR-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.27 ANGSTROMS) IN COMPLEX WITH FMN.
    3. "High resolution crystal structure and in solution studies of the Old Yellow Enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
      Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
      Submitted (MAR-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FMN.

    Entry informationi

    Entry nameiQ2TJB8_TRYCR
    AccessioniPrimary (citable) accession number: Q2TJB8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3