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Q2TJB8

- Q2TJB8_TRYCR

UniProt

Q2TJB8 - Q2TJB8_TRYCR

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Protein
Submitted name:

Dehydrogenase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031FMNImported
Binding sitei195 – 1951FMNImported
Binding sitei249 – 2491FMNImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 283FMNImported
Nucleotide bindingi313 – 3153FMNImported
Nucleotide bindingi336 – 3372FMNImported

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Flavoprotein, FMNImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
DehydrogenaseImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E2BX-ray1.27A1-379[»]
4E2DX-ray2.00A/B/C/D1-379[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TJB8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MATFPELLRP LKLGRYTLRN RIIMAPLTRC QATEDGHVPR TESMLKYYED
60 70 80 90 100
RASAGLIIAE ATMVQPNYTG FLTEPGIYSD AQIEEWRKIV DAVHKKGGLI
110 120 130 140 150
FLQLIHAGRA GIPEKILQQP KSDQDPLAGR LLAASAIPIK DHRIPAYFAA
160 170 180 190 200
SGEKETYGVP EELTDDEVRN GIIPLFVEGA KNAIFKAGFD GVEIHGANGY
210 220 230 240 250
LLDAFFRESS NKRQSGPYAG TTIDTRCQLI YDVTKSVCDA VGSDRVGLRI
260 270 280 290 300
SPLNGVHGMI DSNPEALTKH LCKKIEPLSL AYLHYLRGDM VNQQIGDVVA
310 320 330 340 350
WVRGSYSGVK ISNLRYDFEE ADQQIREGKV DAVAFGAKFI ANPDLVERAQ
360 370
HDWPLNEPRP ETYYTRTAVG YNDYPTYNK
Length:379
Mass (Da):42,222
Last modified:January 24, 2006 - v1
Checksum:i61EB1116CB1EE974
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY863012 Genomic DNA. Translation: AAX54854.1.
AY863013 Genomic DNA. Translation: AAX54855.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY863012 Genomic DNA. Translation: AAX54854.1 .
AY863013 Genomic DNA. Translation: AAX54855.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E2B X-ray 1.27 A 1-379 [» ]
4E2D X-ray 2.00 A/B/C/D 1-379 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view ]
Pfami PF00724. Oxidored_FMN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi."
    Murta S.M., Krieger M.A., Montenegro L.R., Campos F.F., Probst C.M., Avila A.R., Muto N.H., de Oliveira R.C., Nunes L.R., Nirde P., Bruna-Romero O., Goldenberg S., Romanha A.J.
    Mol. Biochem. Parasitol. 146:151-162(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 17LEImported and 17wtImported.
  2. "High resolution crystal structure and in solution studies of the Old Yellow Enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
    Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FMN.
  3. "High resolution crystal structure and in solution studies of the old yellow enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
    Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.27 ANGSTROMS) IN COMPLEX WITH FMN.

Entry informationi

Entry nameiQ2TJB8_TRYCR
AccessioniPrimary (citable) accession number: Q2TJB8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3