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Q2TJB8 (Q2TJB8_TRYCR) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
OrganismTrypanosoma cruzi EMBL AAX54855.1
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding26 – 283FMN PDB 4E2D PDB 4E2B
Nucleotide binding313 – 3153FMN PDB 4E2D PDB 4E2B
Nucleotide binding336 – 3372FMN PDB 4E2D PDB 4E2B

Sites

Binding site611FMN; via amide nitrogen
Binding site1031FMN PDB 4E2D PDB 4E2B
Binding site1951FMN PDB 4E2D PDB 4E2B
Binding site2491FMN PDB 4E2D PDB 4E2B

Sequences

Sequence LengthMass (Da)Tools
Q2TJB8 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 61EB1116CB1EE974

FASTA37942,222
        10         20         30         40         50         60 
MATFPELLRP LKLGRYTLRN RIIMAPLTRC QATEDGHVPR TESMLKYYED RASAGLIIAE 

        70         80         90        100        110        120 
ATMVQPNYTG FLTEPGIYSD AQIEEWRKIV DAVHKKGGLI FLQLIHAGRA GIPEKILQQP 

       130        140        150        160        170        180 
KSDQDPLAGR LLAASAIPIK DHRIPAYFAA SGEKETYGVP EELTDDEVRN GIIPLFVEGA 

       190        200        210        220        230        240 
KNAIFKAGFD GVEIHGANGY LLDAFFRESS NKRQSGPYAG TTIDTRCQLI YDVTKSVCDA 

       250        260        270        280        290        300 
VGSDRVGLRI SPLNGVHGMI DSNPEALTKH LCKKIEPLSL AYLHYLRGDM VNQQIGDVVA 

       310        320        330        340        350        360 
WVRGSYSGVK ISNLRYDFEE ADQQIREGKV DAVAFGAKFI ANPDLVERAQ HDWPLNEPRP 

       370 
ETYYTRTAVG YNDYPTYNK 

« Hide

References

[1]"Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi."
Murta S.M., Krieger M.A., Montenegro L.R., Campos F.F., Probst C.M., Avila A.R., Muto N.H., de Oliveira R.C., Nunes L.R., Nirde P., Bruna-Romero O., Goldenberg S., Romanha A.J.
Mol. Biochem. Parasitol. 146:151-162(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 17LE EMBL AAX54854.1 and 17wt EMBL AAX54855.1.
[2]"High resolution crystal structure and in solution studies of the old yellow enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
Submitted (MAR-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.27 ANGSTROMS) IN COMPLEX WITH FMN.
[3]"High resolution crystal structure and in solution studies of the Old Yellow Enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
Submitted (MAR-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FMN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY863012 Genomic DNA. Translation: AAX54854.1.
AY863013 Genomic DNA. Translation: AAX54855.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4E2BX-ray1.27A1-379[»]
4E2DX-ray2.00A/B/C/D1-379[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2TJB8_TRYCR
AccessionPrimary (citable) accession number: Q2TJB8
Entry history
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)