SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2TJB8

- Q2TJB8_TRYCR

UniProt

Q2TJB8 - Q2TJB8_TRYCR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Dehydrogenase
Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611FMN; via amide nitrogen
Binding sitei103 – 1031FMNImported
Binding sitei195 – 1951FMNImported
Binding sitei249 – 2491FMNImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 283FMNImported
Nucleotide bindingi313 – 3153FMNImported
Nucleotide bindingi336 – 3372FMNImported

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Flavoprotein, FMNImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
DehydrogenaseImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E2BX-ray1.27A1-379[»]
4E2DX-ray2.00A/B/C/D1-379[»]

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TJB8-1 [UniParc]FASTAAdd to Basket

« Hide

MATFPELLRP LKLGRYTLRN RIIMAPLTRC QATEDGHVPR TESMLKYYED    50
RASAGLIIAE ATMVQPNYTG FLTEPGIYSD AQIEEWRKIV DAVHKKGGLI 100
FLQLIHAGRA GIPEKILQQP KSDQDPLAGR LLAASAIPIK DHRIPAYFAA 150
SGEKETYGVP EELTDDEVRN GIIPLFVEGA KNAIFKAGFD GVEIHGANGY 200
LLDAFFRESS NKRQSGPYAG TTIDTRCQLI YDVTKSVCDA VGSDRVGLRI 250
SPLNGVHGMI DSNPEALTKH LCKKIEPLSL AYLHYLRGDM VNQQIGDVVA 300
WVRGSYSGVK ISNLRYDFEE ADQQIREGKV DAVAFGAKFI ANPDLVERAQ 350
HDWPLNEPRP ETYYTRTAVG YNDYPTYNK 379
Length:379
Mass (Da):42,222
Last modified:January 24, 2006 - v1
Checksum:i61EB1116CB1EE974
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY863012 Genomic DNA. Translation: AAX54854.1.
AY863013 Genomic DNA. Translation: AAX54855.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY863012 Genomic DNA. Translation: AAX54854.1 .
AY863013 Genomic DNA. Translation: AAX54855.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E2B X-ray 1.27 A 1-379 [» ]
4E2D X-ray 2.00 A/B/C/D 1-379 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view ]
Pfami PF00724. Oxidored_FMN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi."
    Murta S.M., Krieger M.A., Montenegro L.R., Campos F.F., Probst C.M., Avila A.R., Muto N.H., de Oliveira R.C., Nunes L.R., Nirde P., Bruna-Romero O., Goldenberg S., Romanha A.J.
    Mol. Biochem. Parasitol. 146:151-162(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 17LEImported and 17wtImported.
  2. "High resolution crystal structure and in solution studies of the old yellow enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
    Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.27 ANGSTROMS) IN COMPLEX WITH FMN.
  3. "High resolution crystal structure and in solution studies of the Old Yellow Enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity."
    Murakami M.T., Rodrigues N.C., Gava L.M., Canduri F., Oliva G., Barbosa L.R.S., Borgers J.C.
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FMN.

Entry informationi

Entry nameiQ2TJB8_TRYCR
AccessioniPrimary (citable) accession number: Q2TJB8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi