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Q2TJA4

- Q2TJA4_CANFA

UniProt

Q2TJA4 - Q2TJA4_CANFA

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Protein
Submitted name: 2'-5' oligoadenylate synthetase 1
Gene
OAS1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 2'-5'-oligoadenylate synthetase activity Source: UniProtKB
  2. ATP binding Source: InterPro
  3. double-stranded RNA binding Source: InterPro

GO - Biological processi

  1. defense response to virus Source: UniProtKB
  2. immune response Source: InterPro
  3. negative regulation of viral genome replication Source: UniProtKB
  4. purine nucleotide biosynthetic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2'-5' oligoadenylate synthetase 1Imported
Gene namesi
Name:OAS1Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ2TJA4.
SMRiQ2TJA4. Positions 3-347.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000994.
KOiK14216.

Family and domain databases

Gene3Di1.10.1410.20. 1 hit.
InterProiIPR006117. 2-5-oligoadenylate_synth_CS.
IPR006116. 2-5-oligoadenylate_synth_N.
IPR018952. 2-5-oligoAdlate_synth_1_dom2/C.
IPR026774. 2-5A_synthase.
IPR002934. Nucleotidyltransferase.
[Graphical view]
PANTHERiPTHR11258. PTHR11258. 1 hit.
PfamiPF01909. NTP_transf_2. 1 hit.
PF10421. OAS1_C. 1 hit.
[Graphical view]
PROSITEiPS00832. 25A_SYNTH_1. 1 hit.
PS00833. 25A_SYNTH_2. 1 hit.
PS50152. 25A_SYNTH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TJA4-1 [UniParc]FASTAAdd to Basket

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MPELKDTPAK DLDRFIENYL LPDTQFRRQV KEAIHIISTF LKERCFQGAA    50
HPVRVSKVVK GGSSGKGTTL RGRSDADLVV FLNNLKSFQE QLEKRGQFIW 100
EIKRQLEACQ REETFEVYFE VQSLQWEKPR ALSFVLKSPQ LGEGVEFDVL 150
PAFDVLGQWT NNHRPNPEVY IKLIQECENR GTEGEFSTCF TELQRDFLRQ 200
RPTKVKSLIR LVKHWYQKCK QKLGKPLPPQ YALELLTVYA WERGNHQTEF 250
ITAQGFQTVL KLVLNYQQLC IHWTKYYNFE TPIIKQYLMR QLAKPRPVIL 300
DPADPTGNVA GRDTYGWQRL AQEARVWLSY PCFKKWDGSP VGSWDVLVKP 350
ASSLM 355
Length:355
Mass (Da):41,375
Last modified:January 24, 2006 - v1
Checksum:iAC82B2E538D95181
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY863104 mRNA. Translation: AAX56077.1.
RefSeqiNP_001041596.1. NM_001048131.1.
UniGeneiCfa.21183.

Genome annotation databases

GeneIDi608778.
KEGGicfa:608778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY863104 mRNA. Translation: AAX56077.1 .
RefSeqi NP_001041596.1. NM_001048131.1.
UniGenei Cfa.21183.

3D structure databases

ProteinModelPortali Q2TJA4.
SMRi Q2TJA4. Positions 3-347.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 608778.
KEGGi cfa:608778.

Organism-specific databases

CTDi 4938.

Phylogenomic databases

HOVERGENi HBG000994.
KOi K14216.

Miscellaneous databases

NextBioi 20894409.

Family and domain databases

Gene3Di 1.10.1410.20. 1 hit.
InterProi IPR006117. 2-5-oligoadenylate_synth_CS.
IPR006116. 2-5-oligoadenylate_synth_N.
IPR018952. 2-5-oligoAdlate_synth_1_dom2/C.
IPR026774. 2-5A_synthase.
IPR002934. Nucleotidyltransferase.
[Graphical view ]
PANTHERi PTHR11258. PTHR11258. 1 hit.
Pfami PF01909. NTP_transf_2. 1 hit.
PF10421. OAS1_C. 1 hit.
[Graphical view ]
PROSITEi PS00832. 25A_SYNTH_1. 1 hit.
PS00833. 25A_SYNTH_2. 1 hit.
PS50152. 25A_SYNTH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."
    Perelygin A.A., Zharkikh A.A., Scherbik S.V., Brinton M.A.
    J. Mol. Evol. 63:562-576(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ2TJA4_CANFA
AccessioniPrimary (citable) accession number: Q2TJA4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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