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Q2TJA4

- Q2TJA4_CANFA

UniProt

Q2TJA4 - Q2TJA4_CANFA

Protein
Submitted name:

2'-5' oligoadenylate synthetase 1

Gene

OAS1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 2'-5'-oligoadenylate synthetase activity Source: UniProtKB
    2. ATP binding Source: InterPro
    3. double-stranded RNA binding Source: InterPro

    GO - Biological processi

    1. defense response to virus Source: UniProtKB
    2. immune response Source: InterPro
    3. negative regulation of viral genome replication Source: UniProtKB
    4. purine nucleotide biosynthetic process Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2'-5' oligoadenylate synthetase 1Imported
    Gene namesi
    Name:OAS1Imported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TJA4.
    SMRiQ2TJA4. Positions 3-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG000994.
    KOiK14216.

    Family and domain databases

    Gene3Di1.10.1410.20. 1 hit.
    InterProiIPR006117. 2-5-oligoadenylate_synth_CS.
    IPR006116. 2-5-oligoadenylate_synth_N.
    IPR018952. 2-5-oligoAdlate_synth_1_dom2/C.
    IPR026774. 2-5A_synthase.
    IPR002934. Nucleotidyltransferase.
    [Graphical view]
    PANTHERiPTHR11258. PTHR11258. 1 hit.
    PfamiPF01909. NTP_transf_2. 1 hit.
    PF10421. OAS1_C. 1 hit.
    [Graphical view]
    PROSITEiPS00832. 25A_SYNTH_1. 1 hit.
    PS00833. 25A_SYNTH_2. 1 hit.
    PS50152. 25A_SYNTH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2TJA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPELKDTPAK DLDRFIENYL LPDTQFRRQV KEAIHIISTF LKERCFQGAA    50
    HPVRVSKVVK GGSSGKGTTL RGRSDADLVV FLNNLKSFQE QLEKRGQFIW 100
    EIKRQLEACQ REETFEVYFE VQSLQWEKPR ALSFVLKSPQ LGEGVEFDVL 150
    PAFDVLGQWT NNHRPNPEVY IKLIQECENR GTEGEFSTCF TELQRDFLRQ 200
    RPTKVKSLIR LVKHWYQKCK QKLGKPLPPQ YALELLTVYA WERGNHQTEF 250
    ITAQGFQTVL KLVLNYQQLC IHWTKYYNFE TPIIKQYLMR QLAKPRPVIL 300
    DPADPTGNVA GRDTYGWQRL AQEARVWLSY PCFKKWDGSP VGSWDVLVKP 350
    ASSLM 355
    Length:355
    Mass (Da):41,375
    Last modified:January 24, 2006 - v1
    Checksum:iAC82B2E538D95181
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY863104 mRNA. Translation: AAX56077.1.
    RefSeqiNP_001041596.1. NM_001048131.1.
    UniGeneiCfa.21183.

    Genome annotation databases

    GeneIDi608778.
    KEGGicfa:608778.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY863104 mRNA. Translation: AAX56077.1 .
    RefSeqi NP_001041596.1. NM_001048131.1.
    UniGenei Cfa.21183.

    3D structure databases

    ProteinModelPortali Q2TJA4.
    SMRi Q2TJA4. Positions 3-347.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 608778.
    KEGGi cfa:608778.

    Organism-specific databases

    CTDi 4938.

    Phylogenomic databases

    HOVERGENi HBG000994.
    KOi K14216.

    Miscellaneous databases

    NextBioi 20894409.

    Family and domain databases

    Gene3Di 1.10.1410.20. 1 hit.
    InterProi IPR006117. 2-5-oligoadenylate_synth_CS.
    IPR006116. 2-5-oligoadenylate_synth_N.
    IPR018952. 2-5-oligoAdlate_synth_1_dom2/C.
    IPR026774. 2-5A_synthase.
    IPR002934. Nucleotidyltransferase.
    [Graphical view ]
    PANTHERi PTHR11258. PTHR11258. 1 hit.
    Pfami PF01909. NTP_transf_2. 1 hit.
    PF10421. OAS1_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00832. 25A_SYNTH_1. 1 hit.
    PS00833. 25A_SYNTH_2. 1 hit.
    PS50152. 25A_SYNTH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."
      Perelygin A.A., Zharkikh A.A., Scherbik S.V., Brinton M.A.
      J. Mol. Evol. 63:562-576(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiQ2TJA4_CANFA
    AccessioniPrimary (citable) accession number: Q2TJA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)