Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Palmitoyltransferase ZDHHC5

Gene

ZDHHC5

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5 and for FLOT2.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC5 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 5
Short name:
DHHC-5
Gene namesi
Name:ZDHHC5
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 38ExtracellularSequence analysis4
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 148CytoplasmicSequence analysisAdd BLAST89
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 191ExtracellularSequence analysisAdd BLAST22
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 715CytoplasmicSequence analysisAdd BLAST503

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692281 – 715Palmitoyltransferase ZDHHC5Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphotyrosineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei303PhosphothreonineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei348PhosphothreonineBy similarity1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Modified residuei411PhosphothreonineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei425PhosphoserineBy similarity1
Modified residuei429PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei529PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei617Omega-N-methylarginineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei659PhosphothreonineBy similarity1
Modified residuei684PhosphoserineBy similarity1
Modified residuei694PhosphoserineBy similarity1
Modified residuei697Omega-N-methylarginineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ2THW9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234346.
HOVERGENiHBG057186.
InParanoidiQ2THW9.
KOiK20030.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2THW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAESGKRFK PSKYVPVSAA AIFLVGATTL FFAFTCPGLS LCVSPAVPIY
60 70 80 90 100
NAIVFLFVLA NFSMATFMDP GIFPRAEEDE DKEDDFRAPL YKTVEIKGIQ
110 120 130 140 150
VRMKWCATCR FYRPPRCSHC SVCDNCVEEF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLTAHI MGVFGFGLLY VLYHMEELSG VRTAVTMAVM CVAGLFFIPV
210 220 230 240 250
AGLTGFHVVL VARGRTTNEQ VTGKFRGGVN PFTNGCCNNV SRVLCSSPAP
260 270 280 290 300
RYLGRPKKEK TIVIRPPFLR PEVSDGQITV KIMDNGIQGE LRRSKSKGSL
310 320 330 340 350
EVTESQSADA EPPPPPKPDL SRYTGLRTHL TLAANEDSSL LGKDSPPTPT
360 370 380 390 400
MYKYRPGYSS SSTSAAMPHS SSAKLSRGDS LKEPTSIAES SRHPSYRSEP
410 420 430 440 450
SLEPESFRSP TFGKSFHFDP LSSGSRSSSL KSAQGTGFEL GQLQSIRSEG
460 470 480 490 500
TTSTSYKSLA NQTRNGSLSY DSLLTPSDSP DFESVQAGPE PDPPLGYTSP
510 520 530 540 550
FLSARLAQQR EAERHPRLVP TGPTHREPSP VRYDNLSRHI VASLQEREKL
560 570 580 590 600
LRQSPPLPGR EEEPGLGDSG IQSTPGSGHA PRTSSSSDDS KRSPLVKTPL
610 620 630 640 650
GRPAAPRFGK PDGLRGRGLG SPEPGPTAPY LGRSMSYSSQ KAPAGVSEAE
660 670 680 690 700
EVALQPLLTP KDEVQLKTAY SKSNGQPKSI GSASPGPGQQ PLSSPTRGGV
710
KKVSGVGGTT YEISV
Length:715
Mass (Da):77,385
Last modified:January 24, 2006 - v1
Checksum:i9BEC02E1EFB501C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY871201 mRNA. Translation: AAX68534.1.
RefSeqiNP_001041570.1. NM_001048105.1.
XP_005631102.1. XM_005631045.2.
UniGeneiCfa.30636.

Genome annotation databases

GeneIDi483490.
KEGGicfa:483490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY871201 mRNA. Translation: AAX68534.1.
RefSeqiNP_001041570.1. NM_001048105.1.
XP_005631102.1. XM_005631045.2.
UniGeneiCfa.30636.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2THW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi483490.
KEGGicfa:483490.

Organism-specific databases

CTDi25921.

Phylogenomic databases

HOGENOMiHOG000234346.
HOVERGENiHBG057186.
InParanoidiQ2THW9.
KOiK20030.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC5_CANLF
AccessioniPrimary (citable) accession number: Q2THW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: February 15, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.