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Protein

Probable palmitoyltransferase ZDHHC8

Gene

ZDHHC8

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative palmitoyltransferase involved in glutamatergic transmission.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC8 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 8
Short name:
DHHC-8
Gene namesi
Name:ZDHHC8
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 52LumenalSequence analysisAdd BLAST18
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 148CytoplasmicSequence analysisAdd BLAST75
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 190LumenalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 765CytoplasmicSequence analysisAdd BLAST554

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692291 – 765Probable palmitoyltransferase ZDHHC8Add BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337PhosphoserineBy similarity1
Modified residuei441Omega-N-methylarginineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei627PhosphoserineBy similarity1
Modified residuei675PhosphoserineBy similarity1
Modified residuei682PhosphoserineBy similarity1
Modified residuei725PhosphoserineBy similarity1
Modified residuei743PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ2THW8.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038379.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000234346.
HOVERGENiHBG057186.
InParanoidiQ2THW8.
KOiK20030.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR030291. ZDHHC8.
PANTHERiPTHR12349:SF6. PTHR12349:SF6. 1 hit.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2THW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSPGTRLK PAKYIPVATA AALLVGSSTL FFVFTCPWLT RAVSPAVPVY
60 70 80 90 100
NGIIFLFVLA NFSMATFMDP GVFPRADEDE DKEDDFRAPL YKNVDVRGIQ
110 120 130 140 150
VRMKWCATCH FYRPPRCSHC SVCDNCVEDF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLSAHM VGVVAFGLVY VLNHAEGLGA AHTTITMAVM CVAGLFFIPV
210 220 230 240 250
IGLTGFHVVL VTRGRTTNEH VTGKFRGGVN PFTRGCYGNV EHVLCSPLAP
260 270 280 290 300
RYVVEPPRLP LAARLKPPFL RPELLERAAP LKVKLSDNGL KAGLGRSKSK
310 320 330 340 350
GSLDRLDEKP LDLGPPLPPK AEAGTFGGDL QTPRPSSAES ALSAQRTSPP
360 370 380 390 400
TPAMYKFRPA FPSGPKAPFC GPGEQVPGPD SLTLGEDSIH SLDFASEPSL
410 420 430 440 450
DLPDYTPGGL HAAYPPSPPL SAADTFSGAL RSLSLKAAGR RGGDHVALQP
460 470 480 490 500
LRSEGGPPTP HRGIFAPHAL PNRNGSLSYD SLLNPGSPGG HTCPAHPSAG
510 520 530 540 550
VASYRSPYLH PGAVGEPPRP PPRSFSPVLG PRPREPSPVR YDNLSRTIMA
560 570 580 590 600
SIQERKDREE RERLLRSQAD SLFGDSGVYD APSSYSLQQA SALADGARGP
610 620 630 640 650
ALRYGSRDDL VAGPGFGGAR NPALQTSVSS LSSAVSRAPR TSSSSLQADL
660 670 680 690 700
ANNNAPGPRP GSGSHRSPVR QGPPSPPSTP RSPSYAGPKA VAFIHTDLPE
710 720 730 740 750
SPPSLAVQRD HPQLKTPPSK LNGQSPGLAR LGPAAGPPGP SASPARHTLV
760
KKVSGVGGTT YEISV
Length:765
Mass (Da):81,292
Last modified:January 24, 2006 - v1
Checksum:i2C6168E85C47DAAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY871202 mRNA. Translation: AAX68535.1.
RefSeqiNP_001104240.1. NM_001110770.1.
UniGeneiCfa.38982.

Genome annotation databases

GeneIDi486415.
KEGGicfa:486415.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDHC8_CANLF
AccessioniPrimary (citable) accession number: Q2THW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families