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Protein

Palmitoyltransferase ZDHHC15

Gene

Zdhhc15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase specific for GAP43 and DLG4/PSD95.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Enzyme regulationi

Inhibited by 2-bromopalmitate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC15 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 15
Short name:
DHHC-15
Gene namesi
Name:Zdhhc15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1562075. Zdhhc15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence analysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Palmitoyltransferase ZDHHC15PRO_0000232504Add
BLAST

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ2TGJ4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002751.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003714.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 17951DHHCPROSITE-ProRule annotationAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ2TGJ4.
KOiK20028.
OMAiYKNEERP.
OrthoDBiEOG091G0AXR.
PhylomeDBiQ2TGJ4.
TreeFamiTF316044.

Family and domain databases

InterProiIPR030293. ZDHHC15.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR22883:SF68. PTHR22883:SF68. 1 hit.
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TGJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGWKMALS GGLRCCRRVL SWVPVLVIVL VVLWSYYAYV FELCLVTVLS
60 70 80 90 100
PAEKVIYLIL YHAIFVFFAW TYWKSIFTLP QQPNQKFHLS YTDKERYKNE
110 120 130 140 150
ERPEVQKQML VDMAKKLPVY TRTGNGAVRF CDRCHLIKPD RCHHCSVCAM
160 170 180 190 200
CVLKMDHHCP WVNNCIGFSN YKFFLQFLAY SVLYCLYIAT TVFSYFIKYW
210 220 230 240 250
RGELPSVRSK FHVLFLLFVA CMFFVSLVIL FGYHCWLVSR NKTTLEAFCT
260 270 280 290 300
PVFTSGPEKN GFNLGFIKNI QQVFGDNKKF WLIPIGSSPG DGHSFPMRSM
310 320 330
NESQNPLLAN EEPWEDNEDE SQDYPEGLSS LAVESET
Length:337
Mass (Da):39,308
Last modified:January 24, 2006 - v1
Checksum:i1FAB27E6F863BA05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886531 mRNA. Translation: AAX73393.1.
RefSeqiNP_001034190.1. NM_001039101.1.
XP_006257207.1. XM_006257145.2.
UniGeneiRn.214711.

Genome annotation databases

EnsembliENSRNOT00000003714; ENSRNOP00000003714; ENSRNOG00000002751.
GeneIDi317235.
KEGGirno:317235.
UCSCiRGD:1562075. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886531 mRNA. Translation: AAX73393.1.
RefSeqiNP_001034190.1. NM_001039101.1.
XP_006257207.1. XM_006257145.2.
UniGeneiRn.214711.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003714.

Proteomic databases

PaxDbiQ2TGJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003714; ENSRNOP00000003714; ENSRNOG00000002751.
GeneIDi317235.
KEGGirno:317235.
UCSCiRGD:1562075. rat.

Organism-specific databases

CTDi158866.
RGDi1562075. Zdhhc15.

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ2TGJ4.
KOiK20028.
OMAiYKNEERP.
OrthoDBiEOG091G0AXR.
PhylomeDBiQ2TGJ4.
TreeFamiTF316044.

Miscellaneous databases

PROiQ2TGJ4.

Gene expression databases

BgeeiENSRNOG00000002751.

Family and domain databases

InterProiIPR030293. ZDHHC15.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR22883:SF68. PTHR22883:SF68. 1 hit.
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH15_RAT
AccessioniPrimary (citable) accession number: Q2TGJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.