Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Palmitoyltransferase ZDHHC15

Gene

Zdhhc15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131Zinc 1By similarity1
Metal bindingi134Zinc 1By similarity1
Metal bindingi144Zinc 1By similarity1
Metal bindingi145Zinc 2By similarity1
Metal bindingi148Zinc 2By similarity1
Metal bindingi151Zinc 1By similarity1
Metal bindingi158Zinc 2By similarity1
Active sitei159S-palmitoyl cysteine intermediatePROSITE-ProRule annotation1
Metal bindingi165Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC15 (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 15
Short name:
DHHC-15
Gene namesi
Name:Zdhhc15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1562075 Zdhhc15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20LumenalBy similarityAdd BLAST20
Transmembranei21 – 41HelicalBy similarityAdd BLAST21
Topological domaini42 – 56CytoplasmicBy similarityAdd BLAST15
Transmembranei57 – 77HelicalBy similarityAdd BLAST21
Topological domaini78 – 172LumenalBy similarityAdd BLAST95
Transmembranei173 – 193HelicalBy similarityAdd BLAST21
Topological domaini194 – 210CytoplasmicBy similarityAdd BLAST17
Transmembranei211 – 234HelicalBy similarityAdd BLAST24
Topological domaini235 – 337LumenalBy similarityAdd BLAST103

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325041 – 337Palmitoyltransferase ZDHHC15Add BLAST337

Post-translational modificationi

Autopalmitoylated (in vitro).By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ2TGJ4
PRIDEiQ2TGJ4

Expressioni

Gene expression databases

BgeeiENSRNOG00000002751

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003714

Structurei

3D structure databases

SMRiQ2TGJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 179DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000234777
HOVERGENiHBG055108
InParanoidiQ2TGJ4
KOiK20028
OMAiGLRCCQR
OrthoDBiEOG091G0AXR
PhylomeDBiQ2TGJ4
TreeFamiTF316044

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2TGJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGWKMALS GGLRCCRRVL SWVPVLVIVL VVLWSYYAYV FELCLVTVLS
60 70 80 90 100
PAEKVIYLIL YHAIFVFFAW TYWKSIFTLP QQPNQKFHLS YTDKERYKNE
110 120 130 140 150
ERPEVQKQML VDMAKKLPVY TRTGNGAVRF CDRCHLIKPD RCHHCSVCAM
160 170 180 190 200
CVLKMDHHCP WVNNCIGFSN YKFFLQFLAY SVLYCLYIAT TVFSYFIKYW
210 220 230 240 250
RGELPSVRSK FHVLFLLFVA CMFFVSLVIL FGYHCWLVSR NKTTLEAFCT
260 270 280 290 300
PVFTSGPEKN GFNLGFIKNI QQVFGDNKKF WLIPIGSSPG DGHSFPMRSM
310 320 330
NESQNPLLAN EEPWEDNEDE SQDYPEGLSS LAVESET
Length:337
Mass (Da):39,308
Last modified:January 24, 2006 - v1
Checksum:i1FAB27E6F863BA05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886531 mRNA Translation: AAX73393.1
RefSeqiNP_001034190.1, NM_001039101.1
XP_006257207.1, XM_006257145.3
UniGeneiRn.214711
Rn.84994

Genome annotation databases

EnsembliENSRNOT00000003714; ENSRNOP00000003714; ENSRNOG00000002751
GeneIDi317235
KEGGirno:317235
UCSCiRGD:1562075 rat

Similar proteinsi

Entry informationi

Entry nameiZDH15_RAT
AccessioniPrimary (citable) accession number: Q2TGJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 24, 2006
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health