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Protein

Palmitoyltransferase ZDHHC18

Gene

Zdhhc18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has palmitoyltransferase activity towards HRAS and LCK.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei220S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC18 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 18
Short name:
DHHC-18
Gene namesi
Name:Zdhhc18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309334 Zdhhc18

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691981 – 386Palmitoyltransferase ZDHHC18Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ2TGJ1
PRIDEiQ2TGJ1

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009235

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini190 – 240DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 42Pro-richAdd BLAST32

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
HOGENOMiHOG000242943
HOVERGENiHBG056239
InParanoidiQ2TGJ1
KOiK16675
PhylomeDBiQ2TGJ1

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2TGJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDCEYQQIS PGAAPPPASP GVHRPGPAAP PGPSPGPAPG APRWSVSGSG
60 70 80 90 100
SGSGSGSGSL GRRPRRKWEV FPGRNRFYCG GRLMLAGHGG VFALTLLLIL
110 120 130 140 150
STTILFFIFD CPYLARTLTL AIPIIAAILF FFVMSCLLQT SFTDPGILPR
160 170 180 190 200
ATICEAAALE KQIDNTGSST YRPPPRTREV MINGQMVKLK YCFTCKMFRP
210 220 230 240 250
PRTSHCSVCD NCVERFDHHC PWVGNCVGRR NYRFFYAFIL SLSFLTAFIF
260 270 280 290 300
ACVVTHLTLL SQGSNFLSAL NKTPAGVLEL VICFFSIWSI LGLSGFHTYL
310 320 330 340 350
VASNLTTNED IKGSWSSKRG GEASVNPYSH KSIITNCCAV LCGPLPPSLI
360 370 380
DRRGFVQSDT VLPSPIRSDE PACGAKPDAS MVGGHP
Length:386
Mass (Da):41,659
Last modified:January 24, 2006 - v1
Checksum:i21ED70C27ADD1E1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886534 mRNA Translation: AAX73396.1
RefSeqiNP_001034428.1, NM_001039339.1
UniGeneiRn.203345

Genome annotation databases

GeneIDi362613
KEGGirno:362613
UCSCiRGD:1309334 rat

Similar proteinsi

Entry informationi

Entry nameiZDH18_RAT
AccessioniPrimary (citable) accession number: Q2TGJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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