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Protein

Palmitoyltransferase ZDHHC18

Gene

Zdhhc18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has palmitoyltransferase activity towards HRAS and LCK.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei220 – 2201S-palmitoyl cysteine intermediateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC18 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 18
Short name:
DHHC-18
Gene namesi
Name:Zdhhc18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309334. Zdhhc18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Palmitoyltransferase ZDHHC18PRO_0000269198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ2TGJ1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009235.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini190 – 24051DHHCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 4232Pro-richAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ2TGJ1.
KOiK16675.
PhylomeDBiQ2TGJ1.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TGJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDCEYQQIS PGAAPPPASP GVHRPGPAAP PGPSPGPAPG APRWSVSGSG
60 70 80 90 100
SGSGSGSGSL GRRPRRKWEV FPGRNRFYCG GRLMLAGHGG VFALTLLLIL
110 120 130 140 150
STTILFFIFD CPYLARTLTL AIPIIAAILF FFVMSCLLQT SFTDPGILPR
160 170 180 190 200
ATICEAAALE KQIDNTGSST YRPPPRTREV MINGQMVKLK YCFTCKMFRP
210 220 230 240 250
PRTSHCSVCD NCVERFDHHC PWVGNCVGRR NYRFFYAFIL SLSFLTAFIF
260 270 280 290 300
ACVVTHLTLL SQGSNFLSAL NKTPAGVLEL VICFFSIWSI LGLSGFHTYL
310 320 330 340 350
VASNLTTNED IKGSWSSKRG GEASVNPYSH KSIITNCCAV LCGPLPPSLI
360 370 380
DRRGFVQSDT VLPSPIRSDE PACGAKPDAS MVGGHP
Length:386
Mass (Da):41,659
Last modified:January 24, 2006 - v1
Checksum:i21ED70C27ADD1E1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886534 mRNA. Translation: AAX73396.1.
RefSeqiNP_001034428.1. NM_001039339.1.
UniGeneiRn.203345.

Genome annotation databases

GeneIDi362613.
KEGGirno:362613.
UCSCiRGD:1309334. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886534 mRNA. Translation: AAX73396.1.
RefSeqiNP_001034428.1. NM_001039339.1.
UniGeneiRn.203345.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009235.

Proteomic databases

PaxDbiQ2TGJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362613.
KEGGirno:362613.
UCSCiRGD:1309334. rat.

Organism-specific databases

CTDi84243.
RGDi1309334. Zdhhc18.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ2TGJ1.
KOiK16675.
PhylomeDBiQ2TGJ1.

Miscellaneous databases

PROiQ2TGJ1.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH18_RAT
AccessioniPrimary (citable) accession number: Q2TGJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: July 6, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.