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Protein

Probable palmitoyltransferase ZDHHC24

Gene

Zdhhc24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC24 (EC:2.3.1.225)
Alternative name(s):
Membrane-associated zinc finger protein DHHC25
Zinc finger DHHC domain-containing protein 24
Short name:
DHHC-24
Gene namesi
Name:Zdhhc24
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1565630. Zdhhc24.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337121 – 284Probable palmitoyltransferase ZDHHC24Add BLAST284

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ2TGI5.
PRIDEiQ2TGI5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019825.
GenevisibleiQ2TGI5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026832.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 144DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 222Leu-richAdd BLAST83

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132405.
HOGENOMiHOG000155773.
HOVERGENiHBG061265.
InParanoidiQ2TGI5.
KOiK18932.
OMAiWIMLISG.
OrthoDBiEOG091G0RWR.
PhylomeDBiQ2TGI5.
TreeFamiTF319523.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2TGI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEPWAARGT EGAPARMPVV FTALWAAVVV LELTYVMVLG PGPPPLEPLA
60 70 80 90 100
RALQLALAAY QLLNLLGNMG LFLRSDPSIR GVMLAGRGLG QGWAYCYQCQ
110 120 130 140 150
SQVPPRSGHC SACRVCILRR DHHCRLLGRC VGFHNYRPFL CLLLHAAGVL
160 170 180 190 200
LHISVLLSPA LSALLQAHSA LYTVALLLLP WLMLLTGKVS LAQFALAFVV
210 220 230 240 250
DTCVAGALLC GAGLLFHGML LLRGQTTWEW ARGQHSYDLG MSHNLQAALG
260 270 280
PRWALVWFWP FLASPLPGDG ITFQTPTDVG LVTS
Length:284
Mass (Da):30,696
Last modified:January 24, 2006 - v1
Checksum:i467D931FBD5A369A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886540 mRNA. Translation: AAX73402.1.
RefSeqiNP_001034189.1. NM_001039100.1.
UniGeneiRn.191488.

Genome annotation databases

EnsembliENSRNOT00000026832; ENSRNOP00000026832; ENSRNOG00000019825.
GeneIDi293665.
KEGGirno:293665.
UCSCiRGD:1565630. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886540 mRNA. Translation: AAX73402.1.
RefSeqiNP_001034189.1. NM_001039100.1.
UniGeneiRn.191488.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026832.

Proteomic databases

PaxDbiQ2TGI5.
PRIDEiQ2TGI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026832; ENSRNOP00000026832; ENSRNOG00000019825.
GeneIDi293665.
KEGGirno:293665.
UCSCiRGD:1565630. rat.

Organism-specific databases

CTDi254359.
RGDi1565630. Zdhhc24.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132405.
HOGENOMiHOG000155773.
HOVERGENiHBG061265.
InParanoidiQ2TGI5.
KOiK18932.
OMAiWIMLISG.
OrthoDBiEOG091G0RWR.
PhylomeDBiQ2TGI5.
TreeFamiTF319523.

Miscellaneous databases

PROiPR:Q2TGI5.

Gene expression databases

BgeeiENSRNOG00000019825.
GenevisibleiQ2TGI5. RN.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDH24_RAT
AccessioniPrimary (citable) accession number: Q2TGI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 24, 2006
Last modified: March 15, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.