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Protein

Heat shock 70 kDa protein 4

Gene

HSPA4

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 4
Alternative name(s):
Heat shock 70-related protein APG-2
Gene namesi
Name:HSPA4
Synonyms:APG2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899421 – 840Heat shock 70 kDa protein 4Add BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei89PhosphotyrosineBy similarity1
Modified residuei336PhosphotyrosineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei430N6-acetyllysineBy similarity1
Modified residuei538PhosphothreonineBy similarity1
Modified residuei546PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei660PhosphotyrosineBy similarity1
Modified residuei679N6-acetyllysineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei773N6-methyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ2TFN9.
PRIDEiQ2TFN9.

Interactioni

Subunit structurei

Interacts with TJP1/ZO-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TJP1O977583EBI-8002398,EBI-6988333

Protein-protein interaction databases

IntActiQ2TFN9. 1 interactor.
MINTiMINT-7212226.
STRINGi9615.ENSCAFP00000001368.

Structurei

3D structure databases

ProteinModelPortaliQ2TFN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228138.
HOVERGENiHBG047955.
InParanoidiQ2TFN9.
KOiK09489.

Family and domain databases

Gene3Di1.20.1270.10. 2 hits.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 2 hits.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TFN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACIS FGPKNRSIGA
60 70 80 90 100
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG
110 120 130 140 150
IKVKYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPCFYTD
160 170 180 190 200
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF
210 220 230 240 250
VDMGHSSYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK
260 270 280 290 300
KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDVDVSGT
310 320 330 340 350
MNRGKFLEMC DDLLARVEPP LRSVLEQAKL RKEDIYAVEI VGGATRIPAV
360 370 380 390 400
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY
410 420 430 440 450
SISLRWNSPA EEGSSDCEVF TKNHSAPFSK VLTFYRKEPF TLEAYYSSPQ
460 470 480 490 500
DLPYPDPAIA QFLVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSASLVEV
510 520 530 540 550
LKFEENEEPM ETDQNAKEEE KMQVDQEEPH AEEQQQQTPA ENKAESEEME
560 570 580 590 600
TSQAASKDKK MDQPPQAKKA KVKTSTVDLP IENQLLWQID REMLNLYIEN
610 620 630 640 650
EGKMIMQDKL KKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNSFTL
660 670 680 690 700
KLEDTENWLY EDGEDQPKQV YVDKLAELKN LGQPIKMRFQ ESEERPKLFE
710 720 730 740 750
ELGKQIQQYM KVISSFKNKE DQYDHLDAAD MLKVEKSTNE AMEWMNNKLN
760 770 780 790 800
LQNKQSLTVD PVVKAKEIEA KIKELMSVCG PIISKPKPKV EPPKEEQKNA
810 820 830 840
EQNGPVDGQG DSPGPQAAEQ GTDTAVPSDS DKKLPEMDID
Length:840
Mass (Da):94,379
Last modified:January 24, 2006 - v1
Checksum:i97FDB1918C45B563
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911512 mRNA. Translation: AAX89038.1.
RefSeqiNP_001041481.1. NM_001048016.1.
UniGeneiCfa.19900.

Genome annotation databases

GeneIDi474680.
KEGGicfa:474680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911512 mRNA. Translation: AAX89038.1.
RefSeqiNP_001041481.1. NM_001048016.1.
UniGeneiCfa.19900.

3D structure databases

ProteinModelPortaliQ2TFN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2TFN9. 1 interactor.
MINTiMINT-7212226.
STRINGi9615.ENSCAFP00000001368.

Proteomic databases

PaxDbiQ2TFN9.
PRIDEiQ2TFN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi474680.
KEGGicfa:474680.

Organism-specific databases

CTDi3308.

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228138.
HOVERGENiHBG047955.
InParanoidiQ2TFN9.
KOiK09489.

Family and domain databases

Gene3Di1.20.1270.10. 2 hits.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 2 hits.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP74_CANLF
AccessioniPrimary (citable) accession number: Q2TFN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.