Q2TCH5 (Q2TCH5_9CNID) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: KillerRed EMBL AAY40168.1
Organism	Anthomedusae sp. DC-2005 EMBL AAY40168.1
Taxonomic identifier	328397 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Cnidaria › Hydrozoa › Hydroida › Anthomedusae › unclassified Anthomedusae

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 3A8S PDB 3GB3 PDB 3GL4 PDB 2WIS PDB 2WIQ PDB 4B30
Gene Ontology (GO)
Biological_process	bioluminescence Inferred from electronic annotation. Source: InterPro generation of precursor metabolites and energy Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	116	1	Cysteine sulfenic acid (-SOH) PDB 4B30
	Modified residue	215	1	Cysteine sulfenic acid (-SOH) PDB 4B30

Sequences

	Sequence		Length	Mass (Da)
	Q2TCH5 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 971613C336C2C552	FASTA	237	26,405
	10 20 30 40 50 60 MEGGPALFQS DMTFKIFIDG EVNGQKFTIV ADGSSKFPHG DFNVHAVCET GKLPMSWKPI 70 80 90 100 110 120 CHLIQYGEPF FARYPDGISH FAQECFPEGL SIDRTVRFEN DGTMTSHHTY ELDDTCVVSR 130 140 150 160 170 180 ITVNCDGFQP DGPIMRDQLV DILPNETHMF PHGPNAVRQL AFIGFTTADG GLMMGHFDSK 190 200 210 220 230 MTFNGSRAIE IPGPHFVTII TKQMRDTSDK RDHVCQREVA YAHSVPRITS AIGSDED

References

[1]	"A genetically encoded photosensitizer." Bulina M.E., Chudakov D.M., Britanova O.V., Yanushevich Y.G., Staroverov D.B., Chepurnykh T.V., Merzlyak E.M., Shkrob M.A., Lukyanov S., Lukyanov K.A. Nat. Biotechnol. 24:95-99(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structural basis for the phototoxicity of the fluorescent protein KillerRed." Carpentier P., Violot S., Blanchoin L., Bourgeois D. FEBS Lett. 583:2839-2842(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-237.
[3]	"Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed." Pletnev S., Gurskaya N.G., Pletneva N.V., Lukyanov K.A., Chudakov D.M., Martynov V.I., Popov V.O., Kovalchuk M.V., Wlodawer A., Dauter Z., Pletnev V. J. Biol. Chem. 284:32028-32039(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).
[4]	"Crystal structure analysis of the fluorescent protein KillerRed." Sakai N., Takemoto K., Matsuda T., Kitago Y., Ayabe T., Nagai T. Submitted (OCT-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 2-237.
[5]	"GFP-like phototransformation mechanisms in the cytotoxic fluorescent protein KillerRed unraveled by structural and spectroscopic investigations." de Rosny E., Carpentier P. J. Am. Chem. Soc. 134:18015-18021(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), CYSTEINE SULFENIC ACID (-SOH) AT CYS-116 AND CYS-215.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY969116 mRNA. Translation: AAY40168.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WIQ	X-ray	2.00	A/B	2-237	[»]
2WIS	X-ray	2.35	A/B	2-237	[»]
3A8S	X-ray	2.90	A/B	2-237	[»]
3GB3	X-ray	1.75	A/B	1-237	[»]
3GL4	X-ray	2.15	A/B	1-237	[»]
4B30	X-ray	2.10	A/B	1-237	[»]

ProteinModelPortal

Q2TCH5.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.40.155.10. 1 hit.

InterPro

IPR009017. GFP.
IPR011584. GFP-related.
IPR023413. GFP_like.
IPR000786. Green_fluorescent_prot.
[Graphical view]

Pfam

PF01353. GFP. 1 hit.
[Graphical view]

PRINTS

PR01229. GFLUORESCENT.

SUPFAM

SSF54511. GFP_like. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q2TCH5.

Entry information

Entry name

Q2TCH5_9CNID

Accession

Primary (citable) accession number: Q2TCH5

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)