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Protein

Proteasome subunit beta type-1

Gene

PSMB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.990.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-1 (EC:3.4.25.1)
Gene namesi
Name:PSMB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotation
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00002596221 – 28By similarityAdd BLAST28
ChainiPRO_000023985329 – 241Proteasome subunit beta type-1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi58O-linked (GlcNAc)By similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei68PhosphoserineBy similarity1
Modified residuei150PhosphotyrosineBy similarity1
Modified residuei162PhosphoserineBy similarity1
Modified residuei204N6-acetyllysineBy similarity1
Glycosylationi209O-linked (GlcNAc)By similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2TBX6.
PeptideAtlasiQ2TBX6.
PRIDEiQ2TBX6.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Protein-protein interaction databases

IntActiQ2TBX6. 1 interactor.
STRINGi9913.ENSBTAP00000010108.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 45Combined sources7
Beta strandi48 – 54Combined sources7
Beta strandi57 – 59Combined sources3
Beta strandi62 – 66Combined sources5
Beta strandi71 – 75Combined sources5
Beta strandi78 – 84Combined sources7
Helixi86 – 107Combined sources22
Helixi113 – 125Combined sources13
Turni126 – 129Combined sources4
Beta strandi134 – 141Combined sources8
Beta strandi147 – 152Combined sources6
Beta strandi158 – 167Combined sources10
Helixi170 – 180Combined sources11
Helixi196 – 213Combined sources18
Beta strandi219 – 227Combined sources9
Beta strandi230 – 237Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IRUX-ray2.751/M29-241[»]
ProteinModelPortaliQ2TBX6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2TBX6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0179. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000091081.
HOVERGENiHBG000961.
InParanoidiQ2TBX6.
KOiK02732.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSVAAYSG AGRDLAMEPH SSVGPLQLRF SPYAFNGGTV LAIAGEDFSI
60 70 80 90 100
VASDTRLSEG FSIHTRDSPK CYKLTDKTVI GCSGFHGDCL TLTKIIEARL
110 120 130 140 150
KMYKHSNNKA MTTGAIAAML STILYSRRFF PYYVYNIIGG LDEEGKGAVY
160 170 180 190 200
SFDPVGSYQR DSFKAGGSAS AMLQPLLDNQ VGFKNMQNVE HVPLSLDRAM
210 220 230 240
RLVKDVFISA AERDVYTGDA LKVCIVTKEG IRGETVPLRK D
Length:241
Mass (Da):26,246
Last modified:January 24, 2006 - v1
Checksum:i8682655C19CF2ACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109494 mRNA. Translation: AAI09495.1.
RefSeqiNP_001033628.1. NM_001038539.2.
UniGeneiBt.7040.

Genome annotation databases

GeneIDi514237.
KEGGibta:514237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109494 mRNA. Translation: AAI09495.1.
RefSeqiNP_001033628.1. NM_001038539.2.
UniGeneiBt.7040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IRUX-ray2.751/M29-241[»]
ProteinModelPortaliQ2TBX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2TBX6. 1 interactor.
STRINGi9913.ENSBTAP00000010108.

Protein family/group databases

MEROPSiT01.990.

Proteomic databases

PaxDbiQ2TBX6.
PeptideAtlasiQ2TBX6.
PRIDEiQ2TBX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514237.
KEGGibta:514237.

Organism-specific databases

CTDi5689.

Phylogenomic databases

eggNOGiKOG0179. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000091081.
HOVERGENiHBG000961.
InParanoidiQ2TBX6.
KOiK02732.

Miscellaneous databases

EvolutionaryTraceiQ2TBX6.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSB1_BOVIN
AccessioniPrimary (citable) accession number: Q2TBX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 24, 2006
Last modified: October 5, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.