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Protein

Translocon-associated protein subunit delta

Gene

SSR4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit delta
Short name:
TRAP-delta
Alternative name(s):
Signal sequence receptor subunit delta
Short name:
SSR-delta
Gene namesi
Name:SSR4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 143LumenalSequence analysisAdd BLAST119
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 172CytoplasmicSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000028495725 – 172Translocon-associated protein subunit deltaAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 56By similarity
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Disulfide bond, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ2TBX5.
PeptideAtlasiQ2TBX5.
PRIDEiQ2TBX5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021421.

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028556.

Structurei

3D structure databases

ProteinModelPortaliQ2TBX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-delta family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4088. Eukaryota.
ENOG4111GCB. LUCA.
GeneTreeiENSGT00390000008992.
HOGENOMiHOG000293353.
HOVERGENiHBG002293.
InParanoidiQ2TBX5.
KOiK04571.
OMAiYMAFSAK.
OrthoDBiEOG091G0UKL.
TreeFamiTF313158.

Family and domain databases

InterProiIPR008855. TRAP-delta.
[Graphical view]
PANTHERiPTHR12731. PTHR12731. 1 hit.
PfamiPF05404. TRAP-delta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALASLGAL ALLLLSGLSC CSEACVEPQI TPSYYTTSDA VISTETVFIV
60 70 80 90 100
EISLTCKNRV QNMALYADVS GKQFPVTRGQ DVGRYQVSWS LDHKSAHAGT
110 120 130 140 150
YEVRFFDEES YSLLRKAQRN NEDVSVIPPL FTVSVDHRGT WNGPWVSTEV
160 170
LAAAIGLVIY YLAFSAKSHI QA
Length:172
Mass (Da):18,814
Last modified:January 24, 2006 - v1
Checksum:i11D9240C1AC4CA78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109500 mRNA. Translation: AAI09501.1.
RefSeqiNP_001033592.1. NM_001038503.2.
UniGeneiBt.7288.

Genome annotation databases

EnsembliENSBTAT00000028556; ENSBTAP00000028556; ENSBTAG00000021421.
GeneIDi504438.
KEGGibta:504438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109500 mRNA. Translation: AAI09501.1.
RefSeqiNP_001033592.1. NM_001038503.2.
UniGeneiBt.7288.

3D structure databases

ProteinModelPortaliQ2TBX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028556.

Proteomic databases

PaxDbiQ2TBX5.
PeptideAtlasiQ2TBX5.
PRIDEiQ2TBX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028556; ENSBTAP00000028556; ENSBTAG00000021421.
GeneIDi504438.
KEGGibta:504438.

Organism-specific databases

CTDi6748.

Phylogenomic databases

eggNOGiKOG4088. Eukaryota.
ENOG4111GCB. LUCA.
GeneTreeiENSGT00390000008992.
HOGENOMiHOG000293353.
HOVERGENiHBG002293.
InParanoidiQ2TBX5.
KOiK04571.
OMAiYMAFSAK.
OrthoDBiEOG091G0UKL.
TreeFamiTF313158.

Gene expression databases

BgeeiENSBTAG00000021421.

Family and domain databases

InterProiIPR008855. TRAP-delta.
[Graphical view]
PANTHERiPTHR12731. PTHR12731. 1 hit.
PfamiPF05404. TRAP-delta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSRD_BOVIN
AccessioniPrimary (citable) accession number: Q2TBX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.